{"id":21489,"date":"2024-03-13T00:18:56","date_gmt":"2024-03-12T15:18:56","guid":{"rendered":"http:\/\/mhjn.dothome.co.kr\/%ec%83%9d%ec%84%b1%ed%98%95-ai%eb%a1%9c-%ec%83%88%eb%a1%9c%ec%9a%b4-%eb%b6%84%ec%9e%90-%eb%b0%9c%ea%b5%b4%ed%95%b4-%ec%9e%84%ec%83%81-2%ec%83%81-%ec%8b%9c%ed%97%98%ea%b9%8c%ec%a7%80\/"},"modified":"2024-03-13T00:18:56","modified_gmt":"2024-03-12T15:18:56","slug":"%ec%83%9d%ec%84%b1%ed%98%95-ai%eb%a1%9c-%ec%83%88%eb%a1%9c%ec%9a%b4-%eb%b6%84%ec%9e%90-%eb%b0%9c%ea%b5%b4%ed%95%b4-%ec%9e%84%ec%83%81-2%ec%83%81-%ec%8b%9c%ed%97%98%ea%b9%8c%ec%a7%80","status":"publish","type":"post","link":"https:\/\/mhjn.dothome.co.kr\/en\/%ec%83%9d%ec%84%b1%ed%98%95-ai%eb%a1%9c-%ec%83%88%eb%a1%9c%ec%9a%b4-%eb%b6%84%ec%9e%90-%eb%b0%9c%ea%b5%b4%ed%95%b4-%ec%9e%84%ec%83%81-2%ec%83%81-%ec%8b%9c%ed%97%98%ea%b9%8c%ec%a7%80\/","title":{"rendered":"\uc0dd\uc131\ud615 AI\ub85c \uc0c8\ub85c\uc6b4 \ubd84\uc790 \ubc1c\uad74\ud574 \uc784\uc0c1 2\uc0c1 \uc2dc\ud5d8\uae4c\uc9c0"},"content":{"rendered":"

— \uc12c\uc720\uc99d \uc9c8\ud658 \uce58\ub8cc \uc704\ud55c \ucd5c\ucd08\uc758 TNIK \uc5b5\uc81c\uc81c, AI \ud65c\uc6a9\ud574 \ubc1c\uacac \ubc0f \uc124\uacc4<\/p>\n

Nature Biotechnology\uc5d0 AI \uc54c\uace0\ub9ac\uc998\ubd80\ud130 \uc784\uc0c1 2\uc0c1\uae4c\uc9c0 INS018_055 \uc804 \uc5f0\uad6c \uacfc\uc815 \ucd5c\ucd08 \uacf5\uac1c \uc774 \uc5f0\uad6c\uc5d0 \ucc38\uace0\ub41c 13\uac1c \uc804\uc784\uc0c1 \uc2e4\ud5d8, 3\uac1c \uc784\uc0c1 \uc2dc\ud5d8 \ub370\uc774\ud130\ub294 Insilico \ub370\uc774\ud130\ub8f8[https:\/\/insilico.com\/repository\/nbt-ins018-055-tnik<\/a> ]\uc5d0\uc11c \ud655\uc778 \uac00\ub2a5 Insilico, ChatGPT-4 Turbo\uc640 \ub0b4\ubd80 LLM \uae30\ubc18\uc73c\ub85c PaperGPT[https:\/\/papers.insilicogpt.com\/<\/a> ] \uc2dc\uc2a4\ud15c \uac1c\ubc1c, \ucc44\ud305 \uae30\ub2a5 \ud1b5\ud574 \ub17c\ubb38 \uad00\ub828 \ub2f5\ubcc0 \uc81c\uacf5 <\/p>\n

\ub274\uc695, \ud64d\ucf69 2024\ub144 3\uc6d4 13\uc77c \/PRNewswire=\uc5f0\ud569\ub274\uc2a4\/ — \uc804 \uc138\uacc4\uc801\uc73c\ub85c \uce58\ub8cc\ubc95\uc774\ub098 \uce58\ub8cc\uc81c\uac00 \uc5c6\ub294 \uc9c8\ubcd1\uc740 \uc218\ucc9c \uac00\uc9c0\uc5d0 \uc774\ub978\ub2e4. \uc804\ud1b5\uc801\uc778 \uc2e0\uc57d \ubc1c\uacac\u2022\uac1c\ubc1c\uc5d0\ub294 \uc218\uc2ed \ub144, \uc218\uc2ed\uc5b5 \ub2ec\ub7ec\uac00 \uc18c\uc694\ub418\uba70, \uac1c\ubc1c\ub41c \uc2e0\uc57d\uc758 90% \uc774\uc0c1\uc740 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c \uc2e4\ud328\ud55c\ub2e4. \uc778\uacf5\uc9c0\ub2a5(AI)\uc758 \ub4f1\uc7a5\uc740 \uc774\ub7ec\ud55c \uc2e0\uc57d \uac1c\ubc1c \uacfc\uc815\uc744 \uac04\uc18c\ud654\ud558\uace0 \uac1c\uc120\ud560 \uc218 \uc788\ub294 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud55c\ub2e4. \ub2e4\ub9cc AI \uae30\ubc18\uc758 \uc2e0\uc57d \uac1c\ubc1c \uc2dc\ub300\ub97c \uc5f4\uae30 \uc704\ud574\uc11c\ub294 \ub9ce\uc740 \ube44\uc6a9\uacfc \uc2dc\uac04\uc774 \ub4dc\ub294 \uc804\uc784\uc0c1 \uc138\ud3ec, \uc870\uc9c1, \ub3d9\ubb3c \ubaa8\ub378 \ubc0f \uc778\uac04 \uc784\uc0c1 \uc2dc\ud5d8\uc744 \ud1b5\ud55c \uac80\uc99d \uacfc\uc815\uc774 \ud544\uc218\uc801\uc774\ub2e4.<\/p>\n

Nature Biotechnology[https:\/\/www.nature.com\/articles\/s41587-024-02143-0<\/a> ]\uc5d0 \uac8c\uc7ac\ub41c \uc0c8\ub85c\uc6b4 \uc5f0\uad6c\ub97c \ud1b5\ud574 \uc77c\ubd80 \uc804\uc784\uc0c1 \ubc0f \uc784\uc0c1 \uac80\uc99d \uacb0\uacfc\uac00 \uacf5\uac1c\ub410\ub2e4. \uc774 \ub17c\ubb38\uc5d0\uc11c\ub294 Insilico Medicine\uacfc \ud611\ub825\uc5c5\uccb4\ub4e4\uc774 AI \uc54c\uace0\ub9ac\uc998\uc744 \ud1b5\ud574 \ubc1c\uacac\ud55c \ud45c\uc801\uacfc \uc0c8\ub85c\uc6b4 \ubd84\uc790\ub97c \uae30\ubc18\uc73c\ub85c \uac1c\ubc1c\ud55c \uc120\ub3c4\uc801\uc778 \uce58\ub8cc \ud504\ub85c\uadf8\ub7a8\uc774 \uc784\uc0c1 2\uc0c1 \uc2dc\ud5d8\uc5d0 \uc9c4\ucd9c\ud558\ub294 \uacfc\uc815\uc744 \uc18c\uac1c\ud55c\ub2e4. \ub610\ud55c \uc0dd\uc131\ud615 AI\ub97c \ud65c\uc6a9\ud574 \ucd5c\ucd08\ub85c \ubc1c\uad74\ud55c \ub3d9\uae09 \ucd5c\ucd08\uc758 TNIK \uc5b5\uc81c\uc81c\uc5d0 \ub300\ud55c \uc6d0\uc2dc \uc2e4\ud5d8 \ub370\uc774\ud130\uc640 \uc804\uc784\uc0c1\u2022\uc784\uc0c1 \ud3c9\uac00 \uacb0\uacfc\ub97c \ucc98\uc74c\uc73c\ub85c \uacf5\uac1c\ud55c\ub2e4. \uc774 \uc5f0\uad6c\ub294 AI \uc8fc\ub3c4 \uc2e0\uc57d \uac1c\ubc1c \ubc29\ubc95\ub860\uc758 \ud6a8\uc728\uc131\uacfc \uc18d\ub3c4\ub97c \uac15\uc870\ud558\uba70, \uc5c5\uacc4\ub97c \ud601\uc2e0\ud560 \uc218 \uc788\ub294 \uc0dd\uc131\ud615 AI \uae30\uc220\uc758 \uc720\ub9dd\ud55c \uac00\ub2a5\uc131\uc744 \ubcf4\uc5ec\uc900\ub2e4.<\/p>\n

Insilico Medicine\uc758 \uc124\ub9bd\uc790\uc774\uc790 CEO\uc778 Alex Zhavoronkov<\/span> \ubc15\uc0ac\ub294 “2016\ub144\uc5d0 \uc6b0\ub9ac\uac00 \uc0c8\ub85c\uc6b4 \ubd84\uc790 \uc0dd\uc131\uc744 \uc704\ud55c \uc0dd\uc131\ud615 AI \ubd84\uc57c\uc758 \uccab \ubc88\uc9f8 \ub17c\ubb38\uc744 \ubc1c\ud45c\ud558\uace0 \ub9ce\uc740 \ud6c4\uc18d \ub17c\ubb38\uc744 \ubc1c\ud45c\ud588\uc744 \ub54c, \uc2e0\uc57d \uac1c\ubc1c \ucee4\ubba4\ub2c8\ud2f0\ub294 \ub9e4\uc6b0 \ud68c\uc758\uc801\uc774\uc5c8\ub2e4. \uc5ec\ub7ec \ucc28\ub840\uc758 \uac80\uc99d \uc2e4\ud5d8\uacfc \ud604\uc7ac \ub9ce\uc740 \ubc14\uc774\uc624 \uc81c\uc57d \ud68c\uc0ac\uc5d0\uc11c \uc0ac\uc6a9\ud558\ub294 AI \uc18c\ud504\ud2b8\uc6e8\uc5b4 \ud50c\ub7ab\ud3fc \ucd9c\uc2dc\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ub9ce\uc740 \uc758\ubb38\uc774 \ub0a8\uc544\uc788\uc5c8\ub2e4. \uc5f0\uad6c \ub370\uc774\ud130 \ud2b9\ud788 \ub77c\uc774\ube0c \uc784\uc0c1 \ud504\ub85c\uadf8\ub7a8\uc758 \ub370\uc774\ud130\ub97c \uae30\ubc18\uc73c\ub85c \ubcf4\uba74, \uc9c0\uae08\uae4c\uc9c0 \uc6b0\ub9ac \ubd84\uc57c\uc758 \ub2e4\ub978 \uc5b4\ub5a4 \ud68c\uc0ac\uc5d0\uc11c\ub3c4 \uc774\uc640 \ube44\uc2b7\ud55c \uac83\uc744 \ubcf8 \uc801\uc774 \uc5c6\ub2e4”\uace0 \ubc1d\ud614\ub2e4. \uadf8\ub294 \uc774\uc5b4 “INS018_055\uc758 \uc9c4\uc804\uc740 \uc2e0\uc57d \uac1c\ubc1c \ubd84\uc57c\uc5d0 \uc911\uc694\ud55c \uc758\ubbf8\ub97c \uc9c0\ub2cc\ub2e4\uace0 \uc0dd\uac01\ud55c\ub2e4. \uc774 \uc5f0\uad6c\ub294 \uc5d4\ub4dc\ud22c\uc5d4\ub4dc(end-to-end) AI \uae30\ubc18 \uc2e0\uc57d \uac1c\ubc1c \ud50c\ub7ab\ud3fc\uc778 Pharma.AI\uc758 \uac1c\ub150 \uc99d\uba85 \uc5ed\ud560\uc744 \ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c \uc2e0\uc57d \uac1c\ubc1c\uc744 \uac00\uc18d\ud560 \uc218 \uc788\ub294 \uc0dd\uc131\ud615 AI\uc758 \uc7a0\uc7ac\ub825\uc744 \uc99d\uba85\ud558\ub294 \uc120\ub840\ub97c \uc81c\uc2dc\ud55c\ub2e4. \uc774 \ubc1c\ud45c\ub97c \ud1b5\ud574 \uc0dd\uc131\ud615 AI \uc2e0\uc57d \uac1c\ubc1c \ub3c4\uad6c\uac00 \ucd08\uae30 \ubc1c\uacac \ub2e8\uacc4\uc758 \ub178\ub825\uc744 \uc5b4\ub5bb\uac8c \uac04\uc18c\ud654\ud560 \uc218 \uc788\ub294\uc9c0 \ucd94\ub860\ud574 \ubcfc \uc218 \uc788\ub2e4. \uc6b0\ub9ac\ub294 \uc774 \ud50c\ub7ab\ud3fc\uc758 \ud655\ub300 \uc801\uc6a9\uc73c\ub85c \ube44\uc6a9\uacfc \ud6a8\uc728\uc131 \ub4f1 \uc5c5\uacc4 R&D\uac00 \uc9c1\uba74\ud55c \ubb38\uc81c\ub97c \ud574\uacb0\ud558\uace0, \ud658\uc790\uc5d0\uac8c \ud601\uc2e0\uc801\uc778 \uce58\ub8cc\uc81c\ub97c \ub354 \ube60\ub974\uac8c \uc81c\uacf5\ud560 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uae30\ub300\ud55c\ub2e4”\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n

Insilico\ub294 \ub178\ud654\uc640 \ubc00\uc811\ud55c \uad00\ub828\uc774 \uc788\ub294 \uc0dd\ubb3c\ud559\uc801 \uacfc\uc815\uc778 \uc12c\uc720\uc99d\uc5d0 \ucd08\uc810\uc744 \ub9de\ucdb0 \uc5f0\uad6c\ub97c \uc2dc\uc791\ud588\ub2e4. \uc5f0\uad6c\ud300\uc740 \uba3c\uc800 \uc870\uc9c1 \uc12c\uc720\ud654\uc640 \uad00\ub828\ub41c \uc624\ubbf9\uc2a4 \ubc0f \uc784\uc0c1 \ub370\uc774\ud130 \uc138\ud2b8\ub97c \uc218\uc9d1\ud574 Insilico\uc758 \ub3c5\uc790\uc801\uc778 AI \ud50c\ub7ab\ud3fc Pharma.AI\uc758 \ud45c\uc801 \uc2dd\ubcc4 \uc5d4\uc9c4\uc778 PandaOmics[https:\/\/insilico.com\/pandaomics<\/a> ]\ub97c \ud6c8\ub828\ud588\ub2e4. \ub2e4\uc74c\uc73c\ub85c PandaOmics\ub294 \uc2ec\uce35 \ud2b9\uc9d5 \ud569\uc131, \uc778\uacfc\uad00\uacc4 \ucd94\ub860, \uc2e0\uaddc \uacbd\ub85c \uc7ac\uad6c\uc131\uc744 \ud1b5\ud574 \uc7a0\uc7ac\uc801 \ud45c\uc801 \ub9ac\uc2a4\ud2b8\ub97c \uc81c\uc548\ud588\ub2e4. \uc774\ud6c4 PandaOmics\uc758 \uc790\uc5f0\uc5b4 \ucc98\ub9ac(NLP) \ubaa8\ub378\uc740 \ud2b9\ud5c8, \ucd9c\ud310\ubb3c, \ubcf4\uc870\uae08, \uc784\uc0c1\uc2dc\ud5d8 \ub370\uc774\ud130\ubca0\uc774\uc2a4\ub97c \ud3ec\ud568\ud55c \uc218\ubc31\ub9cc \uac1c\uc758 \ud14d\uc2a4\ud2b8 \ud30c\uc77c\uc744 \ubd84\uc11d\ud574 \uc2e0\uaddc\uc131\uacfc \uc9c8\ubcd1\uc758 \uc5f0\uad00\uc131\uc744 \ucd94\uac00\ub85c \ud3c9\uac00\ud588\ub2e4. \uadf8 \uacb0\uacfc TNIK\uac00 \uac00\uc7a5 \uc720\ub9dd\ud55c \ud56d\uc12c\uc720\uc99d \ud45c\uc801\uc73c\ub85c \ud655\uc778\ub410\ub2e4. \ud2b9\ud788 TNIK\ub294 \uc774\uc804 \uc5f0\uad6c\uc5d0\uc11c \uc5ec\ub7ec \uc12c\uc720\uc99d \uc720\ubc1c \uacbd\ub85c\uc640 \uac04\uc811\uc801\uc73c\ub85c \uc5f0\uad00\ub3fc \uc788\uc5c8\uc9c0\ub9cc, IPF\uc758 \uc7a0\uc7ac\uc801 \ud45c\uc801\uc73c\ub85c \uc8fc\ubaa9\ubc1b\uc740 \uc801\uc740 \uc5c6\uc5c8\ub2e4. Insilico\uc758 \uacfc\ud559\uc790\ub4e4\uc740 \ubcc4\ub3c4\uc758 \ub17c\ubb38\uc5d0\uc11c TNIK\uac00 \ub178\ud654\uc758 \uc5ec\ub7ec \ud2b9\uc9d5[https:\/\/www.aging-us.com\/article\/203960\/text<\/a> ]\uacfc \uad00\ub828\uc774 \uc788\uc744 \uc218 \uc788\uc74c\uc744 \uc785\uc99d\ud588\ub2e4.<\/p>\n

Insilico\uc758 \uacfc\ud559\uc790\ub4e4\uc740 TNIK\ub97c \uc8fc\uc694 \ud45c\uc801\uc73c\ub85c \uc120\uc815\ud55c \ud6c4, \ud68c\uc0ac\uc758 \uc0dd\uc131\ud615 \ud654\ud559 \uc5d4\uc9c4[https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.jcim.2c01191<\/a> ]\uc778 Chemistry42[https:\/\/insilico.com\/chemistry42<\/a> ]\ub97c \ud65c\uc6a9\ud574 \uad6c\uc870 \uae30\ubc18 \uc57d\ubb3c \uc124\uacc4(SBDD) \uc6cc\ud06c\ud50c\ub85c\ub97c \ud1b5\ud574 \uc6d0\ud558\ub294 \ud2b9\uc131\uc744 \uac00\uc9c4 \uc0c8\ub85c\uc6b4 \ubd84\uc790 \uad6c\uc870\ub97c \uc0dd\uc131\ud588\ub2e4. Chemistry42\ub294 40\uac1c \uc774\uc0c1\uc758 \uc0dd\uc131\ud615 \ud654\ud559 \uc54c\uace0\ub9ac\uc998\uacfc 500\uac1c \uc774\uc0c1\uc758 \uc0ac\uc804 \ud559\uc2b5\ub41c \ubcf4\uc0c1 \ubaa8\ub378\uc744 \uacb0\ud569\ud574 \uc0c8\ub85c\uc6b4 \ud654\ud569\ubb3c\uc744 \uc0dd\uc131\ud558\uba70, \uc804\ubb38\uac00\uc758 \ud53c\ub4dc\ubc31\uc744 \uae30\ubc18\uc73c\ub85c \uc0dd\uc131 \ubc0f \uac00\uc0c1 \uc2a4\ud06c\ub9ac\ub2dd \uacfc\uc815\uc744 \ucd5c\uc801\ud654\ud560 \uc218 \uc788\ub2e4. \uc5ec\ub7ec \ucc28\ub840 \ubc18\ubcf5\uc801\uc778 \uc2a4\ud06c\ub9ac\ub2dd\uc744 \ud1b5\ud574 \uc720\ub9dd\ud55c \ud6c4\ubcf4\ubb3c\uc9c8 \ud55c \uac1c\uac00 \ub098\ub178\ubab0\ub77c(nanomolar) IC50 \uac12\uc744 \ubcf4\uc5ec \ud65c\uc131\uc744 \uc785\uc99d\ud588\ub2e4. \uc774 \uadf8\ub8f9\uc740 \uc6a9\ud574\ub3c4\ub97c \ub192\uc774\uace0, \uc6b0\uc218\ud55c ADME \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc744 \ud655\ubcf4\ud558\uba70, \uc6d0\uce58 \uc54a\ub294 \ub3c5\uc131\uc744 \uac10\uc18c\uc2dc\ud0a4\ub294 \ub3d9\uc2dc\uc5d0 TNIK\uc5d0 \ub300\ud55c \ub6f0\uc5b4\ub09c \uce5c\ud654\ub825\uc744 \uc720\uc9c0\ud558\ub3c4\ub85d \ud654\ud569\ubb3c\uc744 \ucd5c\uc801\ud654\ud588\ub2e4. \ucd5c\uc885\uc801\uc73c\ub85c 80\uac1c \ubbf8\ub9cc\uc758 \ubd84\uc790\ub97c \ud569\uc131\ud558\uace0 \ud14c\uc2a4\ud2b8\ud55c \uacb0\uacfc, \uc120\ub3c4 \ubd84\uc790 INS018_055\ub97c \uc0dd\uc0b0\ud588\ub2e4.<\/p>\n

\uc774\ud6c4 \uc804\uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c\u00a0INS018_055\ub294 \uc2dc\ud5d8\uad00 \ubc0f \uc0dd\uccb4 \ub0b4 \uc5f0\uad6c\uc5d0\uc11c IPF\uc5d0 \ub300\ud55c \uc720\uc758\ubbf8\ud55c \ud6a8\ub2a5\uc744 \uc785\uc99d\ud588\uc73c\uba70, \uc5ec\ub7ec \uc138\ud3ec\uc8fc\uc640 \uc885\uc744 \ub300\uc0c1\uc73c\ub85c \uc9c4\ud589\ub41c \uc57d\ub3d9\ud559 \ubc0f \uc548\uc804\uc131 \uc5f0\uad6c\uc5d0\uc11c\ub3c4 \uc720\ub9dd\ud55c \uacb0\uacfc\ub97c \ubcf4\uc5ec\uc92c\ub2e4. \ub610\ud55c INS018_055\ub294 \ub450 \uac00\uc9c0 \ucd94\uac00 \ub3d9\ubb3c \ubaa8\ub378\uc5d0\uc11c \ud53c\ubd80 \ubc0f \uc2e0\uc7a5 \uc12c\uc720\uc99d\uc744 \uc644\ud654\uc2dc\ud0a4\ub294 \ubc94\uc12c\uc720\ud654 \uc5b5\uc81c \uae30\ub2a5\uc744 \uc785\uc99d\ud588\ub2e4. \uc774\ub7ec\ud55c \uc5f0\uad6c \uacb0\uacfc\ub97c \ubc14\ud0d5\uc73c\ub85c INS018_055\ub294 PandaOmics\uac00 2019\ub144 IPF\uc758 \uc7a0\uc7ac\uc801 \uc2e0\uaddc \ud45c\uc801\uc73c\ub85c TNIK\ub97c \uc81c\uc548\ud55c \ud6c4 18\uac1c\uc6d4 \ub9cc\uc778 2021\ub144 2\uc6d4 \uc804\uc784\uc0c1 \ud6c4\ubcf4\ubb3c\uc9c8\ub85c \uc9c0\uc815\ub410\ub2e4[https:\/\/insilico.com\/blog\/pcc<\/a> ].<\/p>\n

INS018_055\ub294 \ud604\uc7ac\uae4c\uc9c0 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c \ud0c1\uc6d4\ud55c \uc131\uacfc\ub97c \ubcf4\uc5ec\uc92c\ub2e4. PCC \uc9c0\uc815 9\uac1c\uc6d4 \ud6c4\uc778 2021\ub144 11\uc6d4 \ud638\uc8fc\uc5d0\uc11c INS018_055\uc758 \uccab \ubc88\uc9f8 \uc778\uccb4 \ub300\uc0c1(FIH) \ubbf8\uc138\uc6a9\ub7c9 \uc2dc\ud5d8[https:\/\/insilico.com\/blog\/fih<\/a> ]\uc744 \uc9c4\ud589\ud574 \uac74\uac15\ud55c \uc9c0\uc6d0\uc790\uc5d0\uac8c \uccab \ud22c\uc5ec\ub97c \uc2e4\uc2dc\ud588\ub2e4. \uc774 \ubbf8\uc138\uc6a9\ub7c9 \uc2dc\ud5d8\uc740 \uae30\ub300 \uc774\uc0c1\uc758 \uacb0\uacfc\ub97c \uc5bb\uc5c8\uc73c\uba70, \uc591\ud638\ud55c \uc57d\ub3d9\ud559 \ubc0f \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc744 \uc81c\uc2dc\ud568\uc73c\ub85c\uc368 \uc784\uc0c1\uc801 \uac1c\ub150 \uc99d\uba85\uc5d0 \uc131\uacf5\ud558\uace0 \ub2e4\uc74c \ub2e8\uacc4 \uc784\uc0c1 \uc2dc\ud5d8\uc758 \uae30\ubc18\uc744 \ub9c8\ub828\ud588\ub2e4. \ub274\uc9c8\ub79c\ub4dc[https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05154240?term=Insilico+Medicine&draw=2&rank=4<\/a> ]\uc640 \uc911\uad6d\uc5d0\uc11c \uc218\ud589\ub41c \uc784\uc0c1 1\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c\ub294 78\uba85\uacfc 48\uba85\uc758 \uac74\uac15\ud55c \ud53c\ud5d8\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ub2e8\uc77c \uc0c1\uc2b9 \uc6a9\ub7c9(SAD) \uc5f0\uad6c\uc640 \ub2e4\uc911 \uc0c1\uc2b9 \uc6a9\ub7c9(MAD) \uc5f0\uad6c\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd98 \ucf54\ud638\ud2b8\ub97c \uad6c\uc131\ud574 \uc2dc\ud5d8\uc744 \uc9c4\ud589\ud588\ub2e4. \uad6d\uc81c \ub2e4\uae30\uad00 \uc784\uc0c1 1\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c \uc77c\uad00\ub41c \uacb0\uacfc\ub97c \uc5bb\uc5c8\uc73c\uba70, INS018_055\uc758 \uc548\uc804\uc131, \ub0b4\uc57d\uc131 \ubc0f \uc57d\ub3d9\ud559(PK) \ud504\ub85c\ud30c\uc77c\uc774 \uc591\ud638\ud558\ub2e4\ub294 \uac83\uc744 \uc785\uc99d\ud588\ub2e4. \uc774\ub294 \uc784\uc0c1 2\uc0c1 \uc2dc\ud5d8 \uac1c\uc2dc\ub97c \ub4b7\ubc1b\uce68\ud558\ub294 \uadfc\uac70\uac00 \ub410\ub2e4.<\/p>\n

Insilico Medicine\uc758 \uacf5\ub3d9 CEO \uacb8 \ucd5c\uace0\uacfc\ud559\ucc45\uc784\uc790\uc778 Feng Ren<\/span> \ubc15\uc0ac\ub294 “AI \uae30\uc220\uacfc \uc778\uac04\uc758 \uc9c0\ub2a5\uc744 \uacb0\ud569\ud574 \uc2dc\uac04\uacfc \ube44\uc6a9\uc744 \ud06c\uac8c \uc904\uc774\uba74\uc11c \uc7a0\uc7ac\uc801\uc73c\ub85c \ub3d9\uae09 \ucd5c\ucd08\uc758 \ud56d\uc12c\uc720\uc99d \uc5b5\uc81c\uc81c\uc778 INS018_055\ub97c \uc131\uacf5\uc801\uc73c\ub85c \ud6c4\ubcf4\ubb3c\uc9c8\ub85c \uc120\uc815\ud588\ub2e4. \uae0d\uc815\uc801\uc778 \uc804\uc784\uc0c1\u2022\uc784\uc0c1 \ub370\uc774\ud130\uc5d0 \ud798\uc785\uc5b4 \uc784\uc0c1 2\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c INS018_055\uc758 \uae0d\uc815\uc801\uc778 \uc131\uacfc\ub97c \uae30\ub300\ud558\uba70, \uc774\ub97c \ud1b5\ud574 \ud658\uc790\uc5d0\uac8c \ud601\uc2e0\uc801\uc778 \uce58\ub8cc \uc635\uc158\uc744 \uc81c\uacf5\ud558\ub294 \ub3d9\uc2dc\uc5d0 AI \uae30\ubc18 \uc2e0\uc57d \uac1c\ubc1c \uc0b0\uc5c5\uc758 \uac00\ub2a5\uc131\uc744 \ub354\uc6b1 \ud655\uc2e4\ud558\uac8c \uc99d\uba85\ud560 \uc218 \uc788\uae30\ub97c \ubc14\ub780\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\uc774\ubc88 \ubc1c\ud45c \uc2dc\uc810\uc5d0 \ubbf8\uad6d\uacfc \uc911\uad6d\uc5d0\uc11c\u00a0IPF \uce58\ub8cc\ub97c \uc704\ud55c INS018_055\uc758 \uc784\uc0c1 2a\uc0c1 \uc2dc\ud5d8[https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05975983?term=Insilico+Medicine&draw=2&rank=2<\/a> ] \ub450 \uac74\uc774 \ubcd1\ud589\ub418\uace0 \uc788\ub2e4. \uc774 \uc2dc\ud5d8\uc740 \ubb34\uc791\uc704, \uc774\uc911\ub9f9\uac80, \uc704\uc57d \ub300\uc870 \uc784\uc0c1 \uc2dc\ud5d8\uc73c\ub85c \uc120\ub3c4 \uc57d\ubb3c\uc758 \uc548\uc804\uc131, \ub0b4\uc57d\uc131 \ubc0f \uc57d\ub3d9\ud559\uc744 \ud3c9\uac00\ud558\uae30 \uc704\ud574 \uc124\uacc4\ub410\ub2e4. \ub354\ubd88\uc5b4 IPF \ud658\uc790\uc758 \ud3d0 \uae30\ub2a5\uc5d0 \ub300\ud55c INS018_055\uc758 \uc608\ube44 \ud6a8\ub2a5\uc744 \ud3c9\uac00\ud560 \uc608\uc815\uc774\ub2e4. \uc774 \uc57d\uc758 \uc9c0\uc18d\uc801\uc778 \ubc1c\uc804\uc740 \uce58\uba85\uc801\uc778 \uc9c8\ubcd1\uc73c\ub85c \uace0\ud1b5\ubc1b\ub294 \uc804 \uc138\uacc4 \uc57d 500\ub9cc \uba85\uc758 \ud658\uc790\ub4e4\uc5d0\uac8c \ud76c\ub9dd\uc744 \uc548\uaca8 \uc904 \uac83\uc774\ub2e4.<\/p>\n

Insilico\ub294 \uac80\uc99d\ub418\uace0 \uc0c1\uc5c5\uc801\uc73c\ub85c \uc2e4\ud589 \uac00\ub2a5\ud55c AI \uc2e0\uc57d \uac1c\ubc1c \ud50c\ub7ab\ud3fc Pharma.AI[https:\/\/insilico.com\/platform\/<\/a> ]\ub97c \ud1b5\ud574 \uc2e0\uc57d \uac1c\ubc1c\uc758 \uc0c8\ub85c\uc6b4 \uc9c0\ud3c9\uc744 \uc5f4\uace0 \uc788\ub2e4. Pharma.AI\ub294 \uc0dd\ubb3c\ud559, \ud654\ud559, \uc784\uc0c1 \uc758\ud559 \ubd84\uc57c\ub97c \uc544\uc6b0\ub974\ub294 \ucca8\ub2e8 \uae30\uc220\ub85c, \uc0dd\uba85\uacf5\ud559 \ubc0f \uc81c\uc57d \uc5c5\uacc4\uc758 \ub0b4\ubd80 \uc5f0\uad6c \uac1c\ubc1c\uc744 \uac00\uc18d\ud558\ub294 \uace0\uae09 \uc0dd\uc131\ud615 AI \ub3c4\uad6c\ub97c \uc81c\uacf5\ud55c\ub2e4. Insilico\ub294 Pharma.AI\ub97c \uae30\ubc18\uc73c\ub85c \uc12c\uc720\uc99d, \uc554, \uba74\uc5ed\ud559, \ub178\ud654 \uad00\ub828 \uc9c8\ud658 \ub4f1 \ub2e4\uc591\ud55c \uc9c8\ubcd1 \ubd84\uc57c\uc5d0\uc11c \uc758\ub8cc \ud601\uc2e0\uc744 \uc774\ub04c\uace0 \uc788\ub2e4. 2021\ub144 \uc774\ud6c4 30\uac1c \uc774\uc0c1\uc758 \uc790\uc0b0\uc73c\ub85c \uad6c\uc131\ub41c \ud3ec\ud2b8\ud3f4\ub9ac\uc624\uc5d0\uc11c 18\uac1c\uc758 \uc804\uc784\uc0c1 \ud6c4\ubcf4\ubb3c\uc9c8\uc744 \uc120\uc815\ud588\uc73c\uba70[https:\/\/insilico.com\/pipeline<\/a> ], 6\uac1c\uc758 \ud30c\uc774\ud504\ub77c\uc778\uc744 \uc784\uc0c1 \ub2e8\uacc4\ub85c \uc9c4\ucd9c\uc2dc\ucf30\ub2e4.<\/p>\n

\uc5c5\uacc4 \uc758\uacac \ubc0f \ucd94\uac00 \uc815\ubcf4<\/p>\n

Insilico Medicine \uacfc\ud559 \uc790\ubb38 \uc704\uc6d0\ud68c(SAB)\uc758 Charles Cantor<\/span> \ubc15\uc0ac\ub294 “AI\uc640 \ub525\ub7ec\ub2dd \ubc29\uc2dd\uc774 \ubbf8\ub798 \uc2e0\uc57d \uac1c\ubc1c \uacfc\uc815\uc744 \uadfc\ubcf8\uc801\uc73c\ub85c \ubc14\uafc0 \uac83\uc774\ub77c\ub294 \ub9ce\uc740 \ucd94\uce21\uc774 \uc788\uc5c8\ub2e4. \uc774 \ub17c\ubb38\uc740 \ub9e4\uc6b0 \uc124\ub4dd\ub825 \uc788\ub294 \uac1c\ub150 \uc99d\uba85\uc744 \uc81c\uc2dc\ud55c\ub2e4. \ud45c\uc801 \uc2dd\ubcc4\ubd80\ud130 \ud6c4\ubcf4 \uc57d\ubb3c \uc120\uc815, 1\uc0c1 \uc5f0\uad6c\uae4c\uc9c0 \uac70\uc758 \ubaa8\ub4e0 \ub2e8\uacc4\uc5d0\uc11c AI\ub97c \ud65c\uc6a9\ud574 \uc0c8\ub85c\uc6b4 \ubd84\uc790\uac00 \uc784\uc0c1 2\uc0c1 \uc2dc\ud5d8\uc5d0 \ub4e4\uc5b4\uac08 \uc900\ube44\uac00 \ub410\ub2e4. \uc774 \uacfc\uc815\uc774 \uc77c\ubc18\ud654\ub418\uba74 AI \uc5c6\uc774 \uc2e0\uc57d \uac1c\ubc1c\uc744 \ud558\ub294 \uac83\uc740 \uc0c1\uc0c1\ud560 \uc218 \uc5c6\uac8c \ub420 \uac83”\uc774\ub77c\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

01.AI\uc758 CEO\uc774\uc790 Sinovation Ventures \ud68c\uc7a5\uc778 Kai-Fu Lee\ub294 “\uc758\ub8cc\ub294 \ub514\uc9c0\ud138\ud654\ub77c\ub294 \uc911\uc694\ud55c \ubcc0\uace1\uc810\uc744 \ub9de\uc774\ud558\uace0 \uc788\ub2e4. AI\uc640 \ub370\uc774\ud130 \uacfc\ud559\uc758 \ud65c\uc6a9\uc740 \uc758\ud559 \ubd84\uc57c\uc5d0 \ud601\uba85\uc744 \uc77c\uc73c\ud0ac \uac83\uc774\ub2e4. Insilico Medicine\uc758 TNIK \ud504\ub85c\uadf8\ub7a8\uc740 \ud654\ud559\uacfc \uc0dd\ubb3c\ud559 \ubd84\uc57c\uc5d0\uc11c \uc0dd\uc131\ud615 AI\ub97c \ud65c\uc6a9\ud574 \ucc98\uc74c\ubd80\ud130 \uc2e0\uc57d\uc744 \ubc1c\uacac\ud558\ub294 \ud68d\uae30\uc801\uc778 \ud328\ub7ec\ub2e4\uc784\uc744 \uc81c\uc2dc\ud55c \ud6cc\ub96d\ud55c \uc0ac\ub840\ub2e4. Insilico\uac00 \uac15\ub825\ud55c \uc2e4\ud5d8 \ub370\uc774\ud130\ub97c \ubc14\ud0d5\uc73c\ub85c \ub2ec\uc131\ud55c \uc131\uacfc\ub294 \ucd5c\ucca8\ub2e8 \uc815\ubcf4 \uae30\uc220\uc744 \ud1b5\ud574 \uc0dd\uba85\uacfc\ud559\uc744 \ubc1c\uc804\uc2dc\ud0a4\ub294 \uc62c\ubc14\ub978 \ubc29\ud5a5\uc73c\ub85c \ub098\uc544\uac00\uace0 \uc788\ub2e4\ub294 \uc99d\uac70\uc774\uba70, \uc804\uccb4 \uc0dd\ud0dc\uacc4\uc5d0 \uae0d\uc815\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\uce60 \uac83”\uc774\ub77c\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

2013\ub144 \ub178\ubca8 \ud654\ud559\uc0c1 \uc218\uc0c1\uc790\uc778 Michael Levitt<\/span> \ubc15\uc0ac\ub294 “\ub9ce\uc740 \uae30\uc5c5\uc774 \uc2e0\uc57d \uac1c\ubc1c\uc758 \uc5ec\ub7ec \ub2e8\uacc4\ub97c \uac1c\uc120\ud558\uae30 \uc704\ud574 AI \uc5f0\uad6c\uc5d0 \ud798\uc4f0\uace0 \uc788\uc9c0\ub9cc, Insilico\ub294 \ubaa8\ub4e0 \ucd08\uae30 \uc2e0\uc57d \uac1c\ubc1c \ubc0f \uc124\uacc4 \ub2e8\uacc4\uc5d0 AI\ub97c \uc801\uc6a9\ud558\ub824\ub294 \uc2dc\ub3c4\ub97c \ud558\uace0 \uc788\uc5b4 \ub9e4\uc6b0 \uae30\ub300\ub41c\ub2e4”\uace0 \ud3c9\uac00\ud588\ub2e4. Levitt \ubc15\uc0ac\ub294 “Insilico\ub294 \ub9d0 \uadf8\ub300\ub85c \ucc98\uc74c\ubd80\ud130 \ub05d\uae4c\uc9c0 AI\ub97c \uc0ac\uc6a9\ud558\ub294 \uae30\uc5c5\uc774\ub2e4. \ub2e8\uc21c\ud788 \uc0c8\ub85c\uc6b4 \ud45c\uc801\uc744 \ubc1c\uad74\ud588\uc744 \ubfd0\ub9cc \uc544\ub2c8\ub77c \ucd08\uae30 \uc2e0\uc57d \uac1c\ubc1c \ud504\ub85c\uc138\uc2a4 \uc804\uccb4\ub97c \uac00\uc18d\ud588\uc73c\uba70, TNIK \ud504\ub85c\uadf8\ub7a8\uc5d0\uc11c AI \ubc29\ubc95\uc758 \uc720\ud6a8\uc131\uc744 \uc131\uacf5\uc801\uc73c\ub85c \uac80\uc99d\ud588\ub2e4. \uc2e0\uc57d \uac1c\ubc1c\uc740 \ubd88\ud655\uc2e4\uc131\uc774 \ub9e4\uc6b0 \ub192\uc740 \uad11\ubc94\uc704\ud55c \ud504\ub85c\uc81d\ud2b8\ub2e4. \uadf8\ub7ec\ub098 AI\ub294 \ubc29\ub300\ud55c \uc591\uc758 \ub370\uc774\ud130\uc5d0 \ub300\ud55c \ud2b9\uc815 \uae30\uc220\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \ud65c\uc6a9\ud560 \uc218 \uc788\uc73c\uba70, \uc774\ub97c \ub611\ub611\ud55c \ud544\ud130\ub9c1\uacfc \uacb0\ud569\ud574 \ubd88\ud655\uc2e4\uc131\uc5d0\uc11c \ud655\uc2e4\uc131\uacfc \uc120\ud0dd\uc9c0\ub97c \ud655\ubcf4\ud560 \uc218 \uc788\ub2e4”\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n

\uce94\uc790\uc2a4 \ub300\ud559\uc758 \uc758\uc57d\ud654\ud559 \ubd80\uad50\uc218\uc774\uc790\u00a0AbbVie\uc758 \uc804 \uae00\ub85c\ubc8c \uc758\uc57d\ud654\ud559 \ub9ac\ub354\uc2ed \ud300\uc7a5\uc778 Stevan Djuric<\/span> \ubc15\uc0ac\ub294 “\ucd5c\uadfc AI, \uba38\uc2e0\ub7ec\ub2dd, \uc0dd\uc131\ud615 \ub514\uc790\uc778\uc758 \uae0d\uc815\uc801 \uce21\uba74\uc5d0 \ub300\ud55c \ubcf4\ub3c4\uac00 \ube48\ubc88\ud558\uac8c \uc774\ub904\uc9c0\uace0 \uc788\ub2e4. \ub2e4\uc18c \uacfc\uc7a5\ub41c \ub290\ub08c\ub3c4 \uc788\uc9c0\ub9cc, \uc774\ubc88 \ub17c\ubb38\uc5d0\uc11c Insilico Medicine \ud300\uc740 \uc55e\uc11c \uc5b8\uae09\ud55c \ub3c4\uad6c\ub97c \ud65c\uc6a9\ud574 \ud45c\uc801 \uc2dd\ubcc4 \ubc0f \uac80\uc99d, \uc758\uc57d\ud654\ud559 \uc124\uacc4 \ubc0f \uc784\uc0c1\uc2dc\ud5d8 \uad6c\uc131 \uc694\uc18c\ub97c \ud3ec\ud568\ud558\ub294 \ub3c5\uc810 \ud50c\ub7ab\ud3fc\uc758 \uac15\ub825\ud55c \uc7a0\uc7ac\ub825\uc744 \uba85\ud655\ud558\uac8c \uc99d\uba85\ud588\ub2e4. \uc219\ub828\ub41c \uc758\uc57d\ud654\ud559\uc790\uc5d0\uac8c\ub294 \ud654\ud569\ubb3c\uc758 \ud6a8\ub2a5 \ud5a5\uc0c1\ubcf4\ub2e4 PK(CLu \ub4f1)\uc640 \uc548\uc804\uc131(\ud45c\uc801 \uc678 \ud6a8\uacfc)\uc758 \uc815\ubc00\ud55c \uc870\uc815\uc774 \ub354 \uc911\uc694\ud55c \uacfc\uc81c\uc778 \uacbd\uc6b0\uac00 \ub9ce\ub2e4. \uc774\ubc88 \uc0ac\ub840\uc5d0\uc11c Insilico \uc5d4\uc9c4\uc740 \uc774\ub7ec\ud55c \ubcf5\uc7a1\ud55c \ubb38\uc81c\uc758 \ubaa8\ub4e0 \uc694\uc18c\ub4e4\uc744 \uc801\uc2dc\uc5d0 \uc131\uacf5\uc801\uc73c\ub85c \ud574\uacb0\ud588\ub2e4. \uc774 \uc57d\uc81c\uc758 \ud5a5\ud6c4 \uc9c4\ud589 \uc0c1\ud669\uacfc \uc0dd\uc131\ud615 AI \ud328\ub7ec\ub2e4\uc784\uc744 \ud65c\uc6a9\ud574 \ubc1c\uad74\ub41c \ud6c4\uc18d \uc784\uc0c1 \ud6c4\ubcf4\uad70\uc5d0 \ub300\ud55c \uc18c\uc2dd\uc744 \uae30\ub300\ud55c\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\ud1a0\ub860\ud1a0 \ub300\ud559\uc758 \ud654\ud559, \ucef4\ud4e8\ud130 \uacf5\ud559 \uad50\uc218\uc774\uc790 Acceleration \ucee8\uc18c\uc2dc\uc5c4\uc758 \ucc45\uc784\uc790\uc778 Al\u00e1n Aspuru-Guzik \ubc15\uc0ac\ub294 “\ub9ce\uc740 \uc0ac\ub78c\uc774 \uc2e0\uc57d \uac1c\ubc1c\uc5d0 AI\ub97c \ud65c\uc6a9\ud55c\ub2e4\uace0 \uc8fc\uc7a5\ud558\uc9c0\ub9cc \uc2e4\uc81c\ub85c \uc131\uacfc\ub97c \ubcf4\uc5ec\uc8fc\ub294 \uacf3\uc740 \ub4dc\ubb3c\ub2e4”\uace0 \uc9c0\uc801\ud588\ub2e4. \uadf8\ub7ec\uba74\uc11c “Insilico \ud300\uc740 AI\ub97c \uae30\ubc18\uc73c\ub85c \ud45c\uc801\uc744 \uc2dd\ubcc4\ud558\uace0 \uce58\ub8cc\uc81c\ub97c \uac1c\ubc1c\ud558\ub294 \ub450 \uac00\uc9c0 \ubaa8\ub450\ub97c \uc131\uacf5\uc801\uc73c\ub85c \uc218\ud589\ud588\ub2e4. \ub0b4\uac00 \uc544\ub294 \ubc14\ub85c\ub294 AI\ub85c \uac1c\ubc1c\ub41c \uc57d\ubb3c\uc774 2\uc0c1 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0 \uc9c4\ucd9c\ud55c \uac83\uc740 \uc774\ubc88\uc774 \ucc98\uc74c\uc774\ub2e4. \uc774\ub294 \ucee4\ubba4\ub2c8\ud2f0\uc640 Insilico \ubaa8\ub450\uc5d0\uac8c \uc9c4\uc815\ud55c \uc774\uc815\ud45c\uc774\uba70, \uc5ec\uae30\uc11c \uc5bb\uc740 \uad50\ud6c8\uc744 \ub354\uc6b1 \ud655\uc7a5\ud558\uba74 \uc2e0\uc57d \ubc1c\uad74 \ubc0f \uac1c\ubc1c \uacfc\uc815\uc5d0 \uc18d\ub3c4\ub97c \ub0bc \uc218 \uc788\uc744 \uac83”\uc774\ub77c\uace0 \uae30\ub300\ud588\ub2e4.<\/p>\n

\ub3c5\uc77c \uc758\ud559\uc704\uc6d0\ud68c \uc778\uc99d \uc57d\ub9ac\ud559\uc790\uc774\uc790 \ub3c5\uc131\ud559\uc790\uc774\uba70\u00a0Insilico Medicine\uc758 \uc804\uc784\uc0c1 \ucee8\uc124\ud134\ud2b8\uc778 Klaus Witte<\/span> \ubc15\uc0ac\ub294 “\uc12c\uc720\uc99d \uc9c8\ud658\uc5d0 \ub300\ud55c INS018_055\uc758 \uc804\uc784\uc0c1 \ud504\ub85c\ud30c\uc77c\ub9c1\uc744 \uc2dc\uc791\ud588\uc744 \ub54c \ubaa8\ub450 \uc774 \uc57d\ubb3c\uc758 \ud45c\uc801 TNIK\ub97c \uc885\uc591 \uce58\ub8cc \ud6c4\ubcf4\ubb3c\uc9c8\ub85c \uc0dd\uac01\ud558\uace0 \uc788\uc5c8\ub2e4”\uace0 \ubc1d\ud614\ub2e4. \uadf8\ub294 “\ucc98\uc74c\uc5d0\ub294 \ud68c\uc758\uc801\uc774\uc5c8\uc9c0\ub9cc \uc6b0\ub9ac\uac00 \uc218\uc9d1\ud55c \ubaa8\ub4e0 \ub370\uc774\ud130\ub294 Insilico\uc758 \ud56d\uc12c\uc720\uc99d \ud6a8\ub2a5 \uc608\uce21\uc744 \uba85\ud655\ud558\uac8c \ub4b7\ubc1b\uce68\ud588\ub2e4. \ud604\uc7ac \ud655\ubcf4\ub41c \ubc29\ub300\ud55c \uc804\uc784\uc0c1\u2022\uc784\uc0c1 \ub370\uc774\ud130\ub97c \uc885\ud569\ud574 \ubcf4\uba74, INS018_055\uac00 \ud3d0\uc12c\uc720\uc99d \ubc0f \uae30\ud0c0 \uc12c\uc720\uc99d \uce58\ub8cc\uc5d0 \ub9e4\uc6b0 \uc720\uc6a9\ud55c \uce58\ub8cc \uc635\uc158\uc774 \ub420 \uc218 \uc788\ub2e4\uace0 \ud655\uc2e0\ud55c\ub2e4. \uc774 \ud654\ud569\ubb3c\uc774 \ud604\uc7ac \ub2e8\uacc4\uc5d0 \ub3c4\ub2ec\ud558\ub3c4\ub85d \uae30\uc5ec\ud55c \uac83\uc740 \uc815\ub9d0 \uc790\ub791\uc2a4\ub7fd\ub2e4”\uace0 \ud588\ub2e4.<\/p>\n

\uc544\ud5e8\uacf5\uacfc\ub300\ud559\uad50\uc758 \uc758\uacfc\ud559\uc790\uc778 Christoph Kuppe<\/span> \ubc15\uc0ac\ub294 “\uc784\uc0c1\uc758\ub85c\uc11c \uc0c8\ub85c\uc6b4 \ud6a8\uacfc\uc801\uc778 \uce58\ub8cc\ubc95\uc758 \ud544\uc694\uc131\uc744 \ubab8\uc18c \ub290\ub07c\uace0 \uc788\ub2e4. \uc774 \ud68d\uae30\uc801\uc778 \uc5f0\uad6c\ub294 \ubc1c\uacac\uc5d0\uc11c \uce58\ub8cc\uae4c\uc9c0\uc758 \uacfc\uc815\uc744 \uac00\uc18d\ud558\uace0, \ud604\uc7ac \uce58\ub8cc \uc635\uc158\uc774 \uc81c\ud55c\uc801\uc778 \uc9c8\ubcd1\uc5d0 \ub300\ud55c \uc6b0\ub9ac\uc758 \uc804\ub7b5\uc744 \uc7ac\uad6c\uc131\ud558\ub294 \ub370 AI\uac00 \uc218\ud589\ud560 \uc218 \uc788\ub294 \ud575\uc2ec\uc801\uc778 \uc5ed\ud560\uc744 \uc798 \ubcf4\uc5ec\uc900\ub2e4”\uace0 \ud3c9\uac00\ud588\ub2e4.<\/p>\n

\ub274\uc695\ub300\ud559\uad50 \ucef4\ud4e8\ud130\uacf5\ud559\uacfc \uad50\uc218\uc778\u00a0Bud Mishra \ubc15\uc0ac\ub294 “Alex\uc640 Insilico\uac00 10\ub144 \ub9cc\uc5d0 \uc774\ub8ec \ub180\ub77c\uc6b4 \uc9c4\uc804\uc5d0 \uae4a\uc740 \uac10\uba85\uc744 \ubc1b\uc558\ub2e4. \uc774 \ub17c\ubb38\uc740 \uc5ec\ub7ec \uc720\uc804\uc790 \ub3cc\uc5f0\ubcc0\uc774\uac00 \uad00\ub828\ub41c \ubcf5\uc7a1\ud55c \uc720\uc804\uc801 \ud2b9\uc9d5\uc744 \uac00\uc9c4 \ud2b9\ubc1c\uc131 \ud3d0\uc12c\uc720\uc99d\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd94\uace0 \uc788\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc774 \ubcf5\uc7a1\ud55c \ubb38\uc81c\ub97c \ub450 \ub2e8\uacc4\ub85c \ub098\ub220 \ud574\uacb0\ud588\ub2e4. \uba3c\uc800 \ud45c\uc801(TNIK)\uc744 \uc120\ud0dd\ud558\uace0 \ud574\ub2f9 \ud45c\uc801\uc5d0 \uacb0\ud569\ud574 \uae30\ub2a5\uc744 \uc800\ud558\ud558\ub294 \uc800\ubd84\uc790 \ud654\ud569\ubb3c\uc744 \uc124\uacc4\ud574 \uc2e0\uc57d \uac1c\ubc1c \uacfc\uc815\uc744 \uc548\ub0b4\ud588\ub2e4”\uace0 \ubc1d\ud614\ub2e4. \uadf8\ub294 “\uccab \ubc88\uc9f8 \ub2e8\uacc4\ub294 \uacfc\uac70 \uacfc\ud559\uc801 \uacbd\ud5d8\uc5d0 \uae30\ubc18\ud55c \ud734\ub9ac\uc2a4\ud2f1(\ud45c\uc801\uc740 \uc0c8\ub86d\uace0, \uc54c\ub824\uc9c4 \uacbd\ub85c\uc640\uc758 \uc0c1\ud638 \uc791\uc6a9\uc744 \uc774\ud574\ud558\uae30 \uc26c\uc6b0\uba70, \uacfc\uac70 \ub2e4\ub978 \uc0ac\ub78c\ub4e4\uc774 \uc2e0\uc57d \uac1c\ubc1c \ubc0f \uc784\uc0c1 \uc2dc\ud5d8\uc744 \uc548\ub0b4\ud558\ub294 \ub370 \uc0ac\uc6a9\ud55c \uc811\uadfc \ubc29\uc2dd\uc744 \ub530\ub77c\uc57c \ud568)\uc744 \uc0ac\uc6a9\ud558\uba70, \uc774\ub294 LLM\uc744 \uc0ac\uc6a9\ud558\ub294 NLP\uc5d0 \uc774\uc0c1\uc801”\uc774\ub77c\uace0 \uc124\uba85\ud588\ub2e4. \uc774\uc5b4 “\ub450 \ubc88\uc9f8 \ub2e8\uacc4\ub294 \ubb34\uc791\uc704 \ud734\ub9ac\uc2a4\ud2f1\uc744 \uc0ac\uc6a9\ud574 DNN\uc73c\ub85c \ubcf5\uc7a1\ud55c \uc870\ud569 \uacf5\uac04\uc744 \uac80\uc0c9\ud558\uace0 \ucd5c\uc801\ud654\ud558\uba70, \uc790\uc5f0\uc801\uc73c\ub85c \ubc1c\uc0dd\ud558\ub294 ‘\uc5b4\ub824\uc6b4 \ubb38\uc81c\uc758 \uc26c\uc6b4 \uc778\uc2a4\ud134\uc2a4’\ub97c \ucc98\ub9ac\ud560 \uc218 \uc788\ub2e4. \uc2dc\uac04\uc774 \uc9c0\ub0a0\uc218\ub85d \uccab \ubc88\uc9f8 \ub2e8\uacc4\ub294 \ub354 \uc5b4\ub824\uc6cc\uc9c0\uace0 (\ud658\uc601 vs. \uc9c4\uc815\ud55c \uc2e0\uae30\uc131), \ub450 \ubc88\uc9f8 \ub2e8\uacc4\ub294 \ub354 \uac04\ub2e8\ud574\uc9c8 \uac83\uc774\ub2e4. \ubb34\uc5b4\uc758 \ubc95\uce59\uc5d0 \ub530\ub77c \uacc4\uc0b0 \ub2a5\ub825\uc774 \uae30\ud558\uae09\uc218\uc801\uc73c\ub85c \ud5a5\uc0c1\ub420 \uac83\uc774\uae30 \ub54c\ubb38”\uc774\ub77c\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n

\ucc38\uace0
Ren, F., et al. A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models. Nat Biotechnol (2024). https:\/\/doi.org\/10.1038\/s41587-024-02143-0<\/a><\/p>\n

Insilico Medicine \uc18c\uac1c<\/p>\n

InSilico Medicine\uc740 \uc0dd\uc131\ud615 AI\ub97c \uac16\ucd98 \uad6d\uc81c \uc784\uc0c1 \ub2e8\uacc4 \uc0dd\uba85\uacf5\ud559 \ud68c\uc0ac\ub85c \ucc28\uc138\ub300 AI \uc2dc\uc2a4\ud15c\uc744 \uc0ac\uc6a9\ud574 \uc0dd\ubb3c\ud559, \ud654\ud559, \uc784\uc0c1\uc2dc\ud5d8\uc744 \uc5f0\uacb0\ud55c\ub2e4. InSilico Medicine\uc740 \uc0c8\ub85c\uc6b4 \ud45c\uc801\uc744 \ubc1c\uacac\ud558\uace0 \uc6d0\ud558\ub294 \uc18d\uc131\uc758 \uc0c8\ub85c\uc6b4 \ubd84\uc790 \uad6c\uc870\ub97c \uc0dd\uc131\ud558\uae30 \uc704\ud574 \ub525 \uc0dd\uc131 \ubaa8\ub378, \uac15\ud654 \ud559\uc2b5, \ubcc0\ud658\uae30 \ubc0f \uae30\ud0c0 \ud604\ub300\uc2dd \uba38\uc2e0 \ub7ec\ub2dd \uae30\uc220\uc744 \uc774\uc6a9\ud558\ub294 AI \ud50c\ub7ab\ud3fc\uc744 \uac1c\ubc1c\ud588\ub2e4. \ud604\uc7ac InSilico Medicine\uc740 \uc554, \uc12c\uc720\uc99d, \uba74\uc5ed, \uc911\ucd94\uc2e0\uacbd\uacc4 \uc9c8\ud658, \uac10\uc5fc \uc9c8\ud658, \uc790\uac00\uba74\uc5ed \uc9c8\ud658 \ubc0f \ub178\ud654 \uad00\ub828 \uc9c8\ud658\uc5d0 \ub300\ud55c \ud601\uc2e0\uc801\uc778 \uc57d\ubb3c\uc744 \ubc1c\uacac\ud558\uace0 \uac1c\ubc1c\ud558\ub294 \ud68d\uae30\uc801\uc778 \uc194\ub8e8\uc158\uc744 \uac1c\ubc1c\ud558\uace0 \uc788\ub2e4. www.Insilico.com<\/a><\/p>","protected":false},"excerpt":{"rendered":"

<\/p>\n

— \uc12c\uc720\uc99d \uc9c8\ud658 \uce58\ub8cc \uc704\ud55c \ucd5c\ucd08\uc758 TNIK \uc5b5\uc81c\uc81c, AI \ud65c\uc6a9\ud574 \ubc1c\uacac \ubc0f \uc124\uacc4<\/p>\n

Nature Biotechnology\uc5d0 AI \uc54c\uace0\ub9ac\uc998\ubd80\ud130 \uc784\uc0c1 2\uc0c1\uae4c\uc9c0 INS018_055 \uc804 \uc5f0\uad6c \uacfc\uc815 \ucd5c\ucd08 \uacf5\uac1c \uc774 \uc5f0\uad6c\uc5d0 \ucc38\uace0\ub41c 13\uac1c \uc804\uc784\uc0c1 \uc2e4\ud5d8, 3\uac1c \uc784\uc0c1 \uc2dc\ud5d8 \ub370\uc774\ud130\ub294 Insilico \ub370\uc774\ud130\ub8f8[https:\/\/insilico.com\/repository\/nbt-ins018-055-tnik<\/a> ]\uc5d0\uc11c \ud655\uc778 \uac00\ub2a5 Insilico, ChatGPT-4 Turbo\uc640 \ub0b4\ubd80 LLM \uae30\ubc18\uc73c\ub85c PaperGPT[https:\/\/papers.insilicogpt.com\/<\/a> ] \uc2dc\uc2a4\ud15c \uac1c\ubc1c, \ucc44\ud305 \uae30\ub2a5 \ud1b5\ud574 \ub17c\ubb38 \uad00\ub828 \ub2f5\ubcc0 \uc81c\uacf5 <\/p>\n

\ub274\uc695, \ud64d\ucf69 2024\ub144 3\uc6d4 13\uc77c \/PRNewswire=\uc5f0\ud569\ub274\uc2a4\/ — \uc804 \uc138\uacc4\uc801\uc73c\ub85c \uce58\ub8cc\ubc95\uc774\ub098 \uce58\ub8cc\uc81c\uac00 \uc5c6\ub294 \uc9c8\ubcd1\uc740 \uc218\ucc9c \uac00\uc9c0\uc5d0 \uc774\ub978\ub2e4. \uc804\ud1b5\uc801\uc778 \uc2e0\uc57d \ubc1c\uacac\u2022\uac1c\ubc1c\uc5d0\ub294 \uc218\uc2ed \ub144, \uc218\uc2ed\uc5b5 \ub2ec\ub7ec\uac00 \uc18c\uc694\ub418\uba70, \uac1c\ubc1c\ub41c \uc2e0\uc57d\uc758 90% \uc774\uc0c1\uc740 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c \uc2e4\ud328\ud55c\ub2e4. \uc778\uacf5\uc9c0\ub2a5(AI)\uc758 \ub4f1\uc7a5\uc740 \uc774\ub7ec\ud55c \uc2e0\uc57d \uac1c\ubc1c \uacfc\uc815\uc744 \uac04\uc18c\ud654\ud558\uace0 \uac1c\uc120\ud560 \uc218 \uc788\ub294 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud55c\ub2e4. \ub2e4\ub9cc AI \uae30\ubc18\uc758 \uc2e0\uc57d \uac1c\ubc1c \uc2dc\ub300\ub97c \uc5f4\uae30 \uc704\ud574\uc11c\ub294 \ub9ce\uc740 \ube44\uc6a9\uacfc \uc2dc\uac04\uc774 \ub4dc\ub294 \uc804\uc784\uc0c1 \uc138\ud3ec, \uc870\uc9c1, \ub3d9\ubb3c \ubaa8\ub378 \ubc0f \uc778\uac04 \uc784\uc0c1 \uc2dc\ud5d8\uc744 \ud1b5\ud55c \uac80\uc99d \uacfc\uc815\uc774 \ud544\uc218\uc801\uc774\ub2e4.<\/p>\n

Nature Biotechnology[https:\/\/www.nature.com\/articles\/s41587-024-02143-0<\/a> ]\uc5d0 \uac8c\uc7ac\ub41c \uc0c8\ub85c\uc6b4 \uc5f0\uad6c\ub97c \ud1b5\ud574 \uc77c\ubd80 \uc804\uc784\uc0c1 \ubc0f \uc784\uc0c1 \uac80\uc99d \uacb0\uacfc\uac00 \uacf5\uac1c\ub410\ub2e4. \uc774 \ub17c\ubb38\uc5d0\uc11c\ub294 Insilico Medicine\uacfc \ud611\ub825\uc5c5\uccb4\ub4e4\uc774 AI \uc54c\uace0\ub9ac\uc998\uc744 \ud1b5\ud574 \ubc1c\uacac\ud55c \ud45c\uc801\uacfc \uc0c8\ub85c\uc6b4 \ubd84\uc790\ub97c \uae30\ubc18\uc73c\ub85c \uac1c\ubc1c\ud55c \uc120\ub3c4\uc801\uc778 \uce58\ub8cc \ud504\ub85c\uadf8\ub7a8\uc774 \uc784\uc0c1 2\uc0c1 \uc2dc\ud5d8\uc5d0 \uc9c4\ucd9c\ud558\ub294 \uacfc\uc815\uc744 \uc18c\uac1c\ud55c\ub2e4. \ub610\ud55c \uc0dd\uc131\ud615 AI\ub97c \ud65c\uc6a9\ud574 \ucd5c\ucd08\ub85c \ubc1c\uad74\ud55c \ub3d9\uae09 \ucd5c\ucd08\uc758 TNIK \uc5b5\uc81c\uc81c\uc5d0 \ub300\ud55c \uc6d0\uc2dc \uc2e4\ud5d8 \ub370\uc774\ud130\uc640 \uc804\uc784\uc0c1\u2022\uc784\uc0c1 \ud3c9\uac00 \uacb0\uacfc\ub97c \ucc98\uc74c\uc73c\ub85c \uacf5\uac1c\ud55c\ub2e4. \uc774 \uc5f0\uad6c\ub294 AI \uc8fc\ub3c4 \uc2e0\uc57d \uac1c\ubc1c \ubc29\ubc95\ub860\uc758 \ud6a8\uc728\uc131\uacfc \uc18d\ub3c4\ub97c \uac15\uc870\ud558\uba70, \uc5c5\uacc4\ub97c \ud601\uc2e0\ud560 \uc218 \uc788\ub294 \uc0dd\uc131\ud615 AI \uae30\uc220\uc758 \uc720\ub9dd\ud55c \uac00\ub2a5\uc131\uc744 \ubcf4\uc5ec\uc900\ub2e4.<\/p>\n

Insilico Medicine\uc758 \uc124\ub9bd\uc790\uc774\uc790 CEO\uc778 Alex Zhavoronkov<\/span> \ubc15\uc0ac\ub294 “2016\ub144\uc5d0 \uc6b0\ub9ac\uac00 \uc0c8\ub85c\uc6b4 \ubd84\uc790 \uc0dd\uc131\uc744 \uc704\ud55c \uc0dd\uc131\ud615 AI \ubd84\uc57c\uc758 \uccab \ubc88\uc9f8 \ub17c\ubb38\uc744 \ubc1c\ud45c\ud558\uace0 \ub9ce\uc740 \ud6c4\uc18d \ub17c\ubb38\uc744 \ubc1c\ud45c\ud588\uc744 \ub54c, \uc2e0\uc57d \uac1c\ubc1c \ucee4\ubba4\ub2c8\ud2f0\ub294 \ub9e4\uc6b0 \ud68c\uc758\uc801\uc774\uc5c8\ub2e4. \uc5ec\ub7ec \ucc28\ub840\uc758 \uac80\uc99d \uc2e4\ud5d8\uacfc \ud604\uc7ac \ub9ce\uc740 \ubc14\uc774\uc624 \uc81c\uc57d \ud68c\uc0ac\uc5d0\uc11c \uc0ac\uc6a9\ud558\ub294 AI \uc18c\ud504\ud2b8\uc6e8\uc5b4 \ud50c\ub7ab\ud3fc \ucd9c\uc2dc\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ub9ce\uc740 \uc758\ubb38\uc774 \ub0a8\uc544\uc788\uc5c8\ub2e4. \uc5f0\uad6c \ub370\uc774\ud130 \ud2b9\ud788 \ub77c\uc774\ube0c \uc784\uc0c1 \ud504\ub85c\uadf8\ub7a8\uc758 \ub370\uc774\ud130\ub97c \uae30\ubc18\uc73c\ub85c \ubcf4\uba74, \uc9c0\uae08\uae4c\uc9c0 \uc6b0\ub9ac \ubd84\uc57c\uc758 \ub2e4\ub978 \uc5b4\ub5a4 \ud68c\uc0ac\uc5d0\uc11c\ub3c4 \uc774\uc640 \ube44\uc2b7\ud55c \uac83\uc744 \ubcf8 \uc801\uc774 \uc5c6\ub2e4”\uace0 \ubc1d\ud614\ub2e4. \uadf8\ub294 \uc774\uc5b4 “INS018_055\uc758 \uc9c4\uc804\uc740 \uc2e0\uc57d \uac1c\ubc1c \ubd84\uc57c\uc5d0 \uc911\uc694\ud55c \uc758\ubbf8\ub97c \uc9c0\ub2cc\ub2e4\uace0 \uc0dd\uac01\ud55c\ub2e4. \uc774 \uc5f0\uad6c\ub294 \uc5d4\ub4dc\ud22c\uc5d4\ub4dc(end-to-end) AI \uae30\ubc18 \uc2e0\uc57d \uac1c\ubc1c \ud50c\ub7ab\ud3fc\uc778 Pharma.AI\uc758 \uac1c\ub150 \uc99d\uba85 \uc5ed\ud560\uc744 \ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c \uc2e0\uc57d \uac1c\ubc1c\uc744 \uac00\uc18d\ud560 \uc218 \uc788\ub294 \uc0dd\uc131\ud615 AI\uc758 \uc7a0\uc7ac\ub825\uc744 \uc99d\uba85\ud558\ub294 \uc120\ub840\ub97c \uc81c\uc2dc\ud55c\ub2e4. \uc774 \ubc1c\ud45c\ub97c \ud1b5\ud574 \uc0dd\uc131\ud615 AI \uc2e0\uc57d \uac1c\ubc1c \ub3c4\uad6c\uac00 \ucd08\uae30 \ubc1c\uacac \ub2e8\uacc4\uc758 \ub178\ub825\uc744 \uc5b4\ub5bb\uac8c \uac04\uc18c\ud654\ud560 \uc218 \uc788\ub294\uc9c0 \ucd94\ub860\ud574 \ubcfc \uc218 \uc788\ub2e4. \uc6b0\ub9ac\ub294 \uc774 \ud50c\ub7ab\ud3fc\uc758 \ud655\ub300 \uc801\uc6a9\uc73c\ub85c \ube44\uc6a9\uacfc \ud6a8\uc728\uc131 \ub4f1 \uc5c5\uacc4 R&D\uac00 \uc9c1\uba74\ud55c \ubb38\uc81c\ub97c \ud574\uacb0\ud558\uace0, \ud658\uc790\uc5d0\uac8c \ud601\uc2e0\uc801\uc778 \uce58\ub8cc\uc81c\ub97c \ub354 \ube60\ub974\uac8c \uc81c\uacf5\ud560 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uae30\ub300\ud55c\ub2e4”\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n

Insilico\ub294 \ub178\ud654\uc640 \ubc00\uc811\ud55c \uad00\ub828\uc774 \uc788\ub294 \uc0dd\ubb3c\ud559\uc801 \uacfc\uc815\uc778 \uc12c\uc720\uc99d\uc5d0 \ucd08\uc810\uc744 \ub9de\ucdb0 \uc5f0\uad6c\ub97c \uc2dc\uc791\ud588\ub2e4. \uc5f0\uad6c\ud300\uc740 \uba3c\uc800 \uc870\uc9c1 \uc12c\uc720\ud654\uc640 \uad00\ub828\ub41c \uc624\ubbf9\uc2a4 \ubc0f \uc784\uc0c1 \ub370\uc774\ud130 \uc138\ud2b8\ub97c \uc218\uc9d1\ud574 Insilico\uc758 \ub3c5\uc790\uc801\uc778 AI \ud50c\ub7ab\ud3fc Pharma.AI\uc758 \ud45c\uc801 \uc2dd\ubcc4 \uc5d4\uc9c4\uc778 PandaOmics[https:\/\/insilico.com\/pandaomics<\/a> ]\ub97c \ud6c8\ub828\ud588\ub2e4. \ub2e4\uc74c\uc73c\ub85c PandaOmics\ub294 \uc2ec\uce35 \ud2b9\uc9d5 \ud569\uc131, \uc778\uacfc\uad00\uacc4 \ucd94\ub860, \uc2e0\uaddc \uacbd\ub85c \uc7ac\uad6c\uc131\uc744 \ud1b5\ud574 \uc7a0\uc7ac\uc801 \ud45c\uc801 \ub9ac\uc2a4\ud2b8\ub97c \uc81c\uc548\ud588\ub2e4. \uc774\ud6c4 PandaOmics\uc758 \uc790\uc5f0\uc5b4 \ucc98\ub9ac(NLP) \ubaa8\ub378\uc740 \ud2b9\ud5c8, \ucd9c\ud310\ubb3c, \ubcf4\uc870\uae08, \uc784\uc0c1\uc2dc\ud5d8 \ub370\uc774\ud130\ubca0\uc774\uc2a4\ub97c \ud3ec\ud568\ud55c \uc218\ubc31\ub9cc \uac1c\uc758 \ud14d\uc2a4\ud2b8 \ud30c\uc77c\uc744 \ubd84\uc11d\ud574 \uc2e0\uaddc\uc131\uacfc \uc9c8\ubcd1\uc758 \uc5f0\uad00\uc131\uc744 \ucd94\uac00\ub85c \ud3c9\uac00\ud588\ub2e4. \uadf8 \uacb0\uacfc TNIK\uac00 \uac00\uc7a5 \uc720\ub9dd\ud55c \ud56d\uc12c\uc720\uc99d \ud45c\uc801\uc73c\ub85c \ud655\uc778\ub410\ub2e4. \ud2b9\ud788 TNIK\ub294 \uc774\uc804 \uc5f0\uad6c\uc5d0\uc11c \uc5ec\ub7ec \uc12c\uc720\uc99d \uc720\ubc1c \uacbd\ub85c\uc640 \uac04\uc811\uc801\uc73c\ub85c \uc5f0\uad00\ub3fc \uc788\uc5c8\uc9c0\ub9cc, IPF\uc758 \uc7a0\uc7ac\uc801 \ud45c\uc801\uc73c\ub85c \uc8fc\ubaa9\ubc1b\uc740 \uc801\uc740 \uc5c6\uc5c8\ub2e4. Insilico\uc758 \uacfc\ud559\uc790\ub4e4\uc740 \ubcc4\ub3c4\uc758 \ub17c\ubb38\uc5d0\uc11c TNIK\uac00 \ub178\ud654\uc758 \uc5ec\ub7ec \ud2b9\uc9d5[https:\/\/www.aging-us.com\/article\/203960\/text<\/a> ]\uacfc \uad00\ub828\uc774 \uc788\uc744 \uc218 \uc788\uc74c\uc744 \uc785\uc99d\ud588\ub2e4.<\/p>\n

Insilico\uc758 \uacfc\ud559\uc790\ub4e4\uc740 TNIK\ub97c \uc8fc\uc694 \ud45c\uc801\uc73c\ub85c \uc120\uc815\ud55c \ud6c4, \ud68c\uc0ac\uc758 \uc0dd\uc131\ud615 \ud654\ud559 \uc5d4\uc9c4[https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.jcim.2c01191<\/a> ]\uc778 Chemistry42[https:\/\/insilico.com\/chemistry42<\/a> ]\ub97c \ud65c\uc6a9\ud574 \uad6c\uc870 \uae30\ubc18 \uc57d\ubb3c \uc124\uacc4(SBDD) \uc6cc\ud06c\ud50c\ub85c\ub97c \ud1b5\ud574 \uc6d0\ud558\ub294 \ud2b9\uc131\uc744 \uac00\uc9c4 \uc0c8\ub85c\uc6b4 \ubd84\uc790 \uad6c\uc870\ub97c \uc0dd\uc131\ud588\ub2e4. Chemistry42\ub294 40\uac1c \uc774\uc0c1\uc758 \uc0dd\uc131\ud615 \ud654\ud559 \uc54c\uace0\ub9ac\uc998\uacfc 500\uac1c \uc774\uc0c1\uc758 \uc0ac\uc804 \ud559\uc2b5\ub41c \ubcf4\uc0c1 \ubaa8\ub378\uc744 \uacb0\ud569\ud574 \uc0c8\ub85c\uc6b4 \ud654\ud569\ubb3c\uc744 \uc0dd\uc131\ud558\uba70, \uc804\ubb38\uac00\uc758 \ud53c\ub4dc\ubc31\uc744 \uae30\ubc18\uc73c\ub85c \uc0dd\uc131 \ubc0f \uac00\uc0c1 \uc2a4\ud06c\ub9ac\ub2dd \uacfc\uc815\uc744 \ucd5c\uc801\ud654\ud560 \uc218 \uc788\ub2e4. \uc5ec\ub7ec \ucc28\ub840 \ubc18\ubcf5\uc801\uc778 \uc2a4\ud06c\ub9ac\ub2dd\uc744 \ud1b5\ud574 \uc720\ub9dd\ud55c \ud6c4\ubcf4\ubb3c\uc9c8 \ud55c \uac1c\uac00 \ub098\ub178\ubab0\ub77c(nanomolar) IC50 \uac12\uc744 \ubcf4\uc5ec \ud65c\uc131\uc744 \uc785\uc99d\ud588\ub2e4. \uc774 \uadf8\ub8f9\uc740 \uc6a9\ud574\ub3c4\ub97c \ub192\uc774\uace0, \uc6b0\uc218\ud55c ADME \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc744 \ud655\ubcf4\ud558\uba70, \uc6d0\uce58 \uc54a\ub294 \ub3c5\uc131\uc744 \uac10\uc18c\uc2dc\ud0a4\ub294 \ub3d9\uc2dc\uc5d0 TNIK\uc5d0 \ub300\ud55c \ub6f0\uc5b4\ub09c \uce5c\ud654\ub825\uc744 \uc720\uc9c0\ud558\ub3c4\ub85d \ud654\ud569\ubb3c\uc744 \ucd5c\uc801\ud654\ud588\ub2e4. \ucd5c\uc885\uc801\uc73c\ub85c 80\uac1c \ubbf8\ub9cc\uc758 \ubd84\uc790\ub97c \ud569\uc131\ud558\uace0 \ud14c\uc2a4\ud2b8\ud55c \uacb0\uacfc, \uc120\ub3c4 \ubd84\uc790 INS018_055\ub97c \uc0dd\uc0b0\ud588\ub2e4.<\/p>\n

\uc774\ud6c4 \uc804\uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c\u00a0INS018_055\ub294 \uc2dc\ud5d8\uad00 \ubc0f \uc0dd\uccb4 \ub0b4 \uc5f0\uad6c\uc5d0\uc11c IPF\uc5d0 \ub300\ud55c \uc720\uc758\ubbf8\ud55c \ud6a8\ub2a5\uc744 \uc785\uc99d\ud588\uc73c\uba70, \uc5ec\ub7ec \uc138\ud3ec\uc8fc\uc640 \uc885\uc744 \ub300\uc0c1\uc73c\ub85c \uc9c4\ud589\ub41c \uc57d\ub3d9\ud559 \ubc0f \uc548\uc804\uc131 \uc5f0\uad6c\uc5d0\uc11c\ub3c4 \uc720\ub9dd\ud55c \uacb0\uacfc\ub97c \ubcf4\uc5ec\uc92c\ub2e4. \ub610\ud55c INS018_055\ub294 \ub450 \uac00\uc9c0 \ucd94\uac00 \ub3d9\ubb3c \ubaa8\ub378\uc5d0\uc11c \ud53c\ubd80 \ubc0f \uc2e0\uc7a5 \uc12c\uc720\uc99d\uc744 \uc644\ud654\uc2dc\ud0a4\ub294 \ubc94\uc12c\uc720\ud654 \uc5b5\uc81c \uae30\ub2a5\uc744 \uc785\uc99d\ud588\ub2e4. \uc774\ub7ec\ud55c \uc5f0\uad6c \uacb0\uacfc\ub97c \ubc14\ud0d5\uc73c\ub85c INS018_055\ub294 PandaOmics\uac00 2019\ub144 IPF\uc758 \uc7a0\uc7ac\uc801 \uc2e0\uaddc \ud45c\uc801\uc73c\ub85c TNIK\ub97c \uc81c\uc548\ud55c \ud6c4 18\uac1c\uc6d4 \ub9cc\uc778 2021\ub144 2\uc6d4 \uc804\uc784\uc0c1 \ud6c4\ubcf4\ubb3c\uc9c8\ub85c \uc9c0\uc815\ub410\ub2e4[https:\/\/insilico.com\/blog\/pcc<\/a> ].<\/p>\n

INS018_055\ub294 \ud604\uc7ac\uae4c\uc9c0 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c \ud0c1\uc6d4\ud55c \uc131\uacfc\ub97c \ubcf4\uc5ec\uc92c\ub2e4. PCC \uc9c0\uc815 9\uac1c\uc6d4 \ud6c4\uc778 2021\ub144 11\uc6d4 \ud638\uc8fc\uc5d0\uc11c INS018_055\uc758 \uccab \ubc88\uc9f8 \uc778\uccb4 \ub300\uc0c1(FIH) \ubbf8\uc138\uc6a9\ub7c9 \uc2dc\ud5d8[https:\/\/insilico.com\/blog\/fih<\/a> ]\uc744 \uc9c4\ud589\ud574 \uac74\uac15\ud55c \uc9c0\uc6d0\uc790\uc5d0\uac8c \uccab \ud22c\uc5ec\ub97c \uc2e4\uc2dc\ud588\ub2e4. \uc774 \ubbf8\uc138\uc6a9\ub7c9 \uc2dc\ud5d8\uc740 \uae30\ub300 \uc774\uc0c1\uc758 \uacb0\uacfc\ub97c \uc5bb\uc5c8\uc73c\uba70, \uc591\ud638\ud55c \uc57d\ub3d9\ud559 \ubc0f \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc744 \uc81c\uc2dc\ud568\uc73c\ub85c\uc368 \uc784\uc0c1\uc801 \uac1c\ub150 \uc99d\uba85\uc5d0 \uc131\uacf5\ud558\uace0 \ub2e4\uc74c \ub2e8\uacc4 \uc784\uc0c1 \uc2dc\ud5d8\uc758 \uae30\ubc18\uc744 \ub9c8\ub828\ud588\ub2e4. \ub274\uc9c8\ub79c\ub4dc[https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05154240?term=Insilico+Medicine&draw=2&rank=4<\/a> ]\uc640 \uc911\uad6d\uc5d0\uc11c \uc218\ud589\ub41c \uc784\uc0c1 1\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c\ub294 78\uba85\uacfc 48\uba85\uc758 \uac74\uac15\ud55c \ud53c\ud5d8\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ub2e8\uc77c \uc0c1\uc2b9 \uc6a9\ub7c9(SAD) \uc5f0\uad6c\uc640 \ub2e4\uc911 \uc0c1\uc2b9 \uc6a9\ub7c9(MAD) \uc5f0\uad6c\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd98 \ucf54\ud638\ud2b8\ub97c \uad6c\uc131\ud574 \uc2dc\ud5d8\uc744 \uc9c4\ud589\ud588\ub2e4. \uad6d\uc81c \ub2e4\uae30\uad00 \uc784\uc0c1 1\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c \uc77c\uad00\ub41c \uacb0\uacfc\ub97c \uc5bb\uc5c8\uc73c\uba70, INS018_055\uc758 \uc548\uc804\uc131, \ub0b4\uc57d\uc131 \ubc0f \uc57d\ub3d9\ud559(PK) \ud504\ub85c\ud30c\uc77c\uc774 \uc591\ud638\ud558\ub2e4\ub294 \uac83\uc744 \uc785\uc99d\ud588\ub2e4. \uc774\ub294 \uc784\uc0c1 2\uc0c1 \uc2dc\ud5d8 \uac1c\uc2dc\ub97c \ub4b7\ubc1b\uce68\ud558\ub294 \uadfc\uac70\uac00 \ub410\ub2e4.<\/p>\n

Insilico Medicine\uc758 \uacf5\ub3d9 CEO \uacb8 \ucd5c\uace0\uacfc\ud559\ucc45\uc784\uc790\uc778 Feng Ren<\/span> \ubc15\uc0ac\ub294 “AI \uae30\uc220\uacfc \uc778\uac04\uc758 \uc9c0\ub2a5\uc744 \uacb0\ud569\ud574 \uc2dc\uac04\uacfc \ube44\uc6a9\uc744 \ud06c\uac8c \uc904\uc774\uba74\uc11c \uc7a0\uc7ac\uc801\uc73c\ub85c \ub3d9\uae09 \ucd5c\ucd08\uc758 \ud56d\uc12c\uc720\uc99d \uc5b5\uc81c\uc81c\uc778 INS018_055\ub97c \uc131\uacf5\uc801\uc73c\ub85c \ud6c4\ubcf4\ubb3c\uc9c8\ub85c \uc120\uc815\ud588\ub2e4. \uae0d\uc815\uc801\uc778 \uc804\uc784\uc0c1\u2022\uc784\uc0c1 \ub370\uc774\ud130\uc5d0 \ud798\uc785\uc5b4 \uc784\uc0c1 2\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c INS018_055\uc758 \uae0d\uc815\uc801\uc778 \uc131\uacfc\ub97c \uae30\ub300\ud558\uba70, \uc774\ub97c \ud1b5\ud574 \ud658\uc790\uc5d0\uac8c \ud601\uc2e0\uc801\uc778 \uce58\ub8cc \uc635\uc158\uc744 \uc81c\uacf5\ud558\ub294 \ub3d9\uc2dc\uc5d0 AI \uae30\ubc18 \uc2e0\uc57d \uac1c\ubc1c \uc0b0\uc5c5\uc758 \uac00\ub2a5\uc131\uc744 \ub354\uc6b1 \ud655\uc2e4\ud558\uac8c \uc99d\uba85\ud560 \uc218 \uc788\uae30\ub97c \ubc14\ub780\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\uc774\ubc88 \ubc1c\ud45c \uc2dc\uc810\uc5d0 \ubbf8\uad6d\uacfc \uc911\uad6d\uc5d0\uc11c\u00a0IPF \uce58\ub8cc\ub97c \uc704\ud55c INS018_055\uc758 \uc784\uc0c1 2a\uc0c1 \uc2dc\ud5d8[https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05975983?term=Insilico+Medicine&draw=2&rank=2<\/a> ] \ub450 \uac74\uc774 \ubcd1\ud589\ub418\uace0 \uc788\ub2e4. \uc774 \uc2dc\ud5d8\uc740 \ubb34\uc791\uc704, \uc774\uc911\ub9f9\uac80, \uc704\uc57d \ub300\uc870 \uc784\uc0c1 \uc2dc\ud5d8\uc73c\ub85c \uc120\ub3c4 \uc57d\ubb3c\uc758 \uc548\uc804\uc131, \ub0b4\uc57d\uc131 \ubc0f \uc57d\ub3d9\ud559\uc744 \ud3c9\uac00\ud558\uae30 \uc704\ud574 \uc124\uacc4\ub410\ub2e4. \ub354\ubd88\uc5b4 IPF \ud658\uc790\uc758 \ud3d0 \uae30\ub2a5\uc5d0 \ub300\ud55c INS018_055\uc758 \uc608\ube44 \ud6a8\ub2a5\uc744 \ud3c9\uac00\ud560 \uc608\uc815\uc774\ub2e4. \uc774 \uc57d\uc758 \uc9c0\uc18d\uc801\uc778 \ubc1c\uc804\uc740 \uce58\uba85\uc801\uc778 \uc9c8\ubcd1\uc73c\ub85c \uace0\ud1b5\ubc1b\ub294 \uc804 \uc138\uacc4 \uc57d 500\ub9cc \uba85\uc758 \ud658\uc790\ub4e4\uc5d0\uac8c \ud76c\ub9dd\uc744 \uc548\uaca8 \uc904 \uac83\uc774\ub2e4.<\/p>\n

Insilico\ub294 \uac80\uc99d\ub418\uace0 \uc0c1\uc5c5\uc801\uc73c\ub85c \uc2e4\ud589 \uac00\ub2a5\ud55c AI \uc2e0\uc57d \uac1c\ubc1c \ud50c\ub7ab\ud3fc Pharma.AI[https:\/\/insilico.com\/platform\/<\/a> ]\ub97c \ud1b5\ud574 \uc2e0\uc57d \uac1c\ubc1c\uc758 \uc0c8\ub85c\uc6b4 \uc9c0\ud3c9\uc744 \uc5f4\uace0 \uc788\ub2e4. Pharma.AI\ub294 \uc0dd\ubb3c\ud559, \ud654\ud559, \uc784\uc0c1 \uc758\ud559 \ubd84\uc57c\ub97c \uc544\uc6b0\ub974\ub294 \ucca8\ub2e8 \uae30\uc220\ub85c, \uc0dd\uba85\uacf5\ud559 \ubc0f \uc81c\uc57d \uc5c5\uacc4\uc758 \ub0b4\ubd80 \uc5f0\uad6c \uac1c\ubc1c\uc744 \uac00\uc18d\ud558\ub294 \uace0\uae09 \uc0dd\uc131\ud615 AI \ub3c4\uad6c\ub97c \uc81c\uacf5\ud55c\ub2e4. Insilico\ub294 Pharma.AI\ub97c \uae30\ubc18\uc73c\ub85c \uc12c\uc720\uc99d, \uc554, \uba74\uc5ed\ud559, \ub178\ud654 \uad00\ub828 \uc9c8\ud658 \ub4f1 \ub2e4\uc591\ud55c \uc9c8\ubcd1 \ubd84\uc57c\uc5d0\uc11c \uc758\ub8cc \ud601\uc2e0\uc744 \uc774\ub04c\uace0 \uc788\ub2e4. 2021\ub144 \uc774\ud6c4 30\uac1c \uc774\uc0c1\uc758 \uc790\uc0b0\uc73c\ub85c \uad6c\uc131\ub41c \ud3ec\ud2b8\ud3f4\ub9ac\uc624\uc5d0\uc11c 18\uac1c\uc758 \uc804\uc784\uc0c1 \ud6c4\ubcf4\ubb3c\uc9c8\uc744 \uc120\uc815\ud588\uc73c\uba70[https:\/\/insilico.com\/pipeline<\/a> ], 6\uac1c\uc758 \ud30c\uc774\ud504\ub77c\uc778\uc744 \uc784\uc0c1 \ub2e8\uacc4\ub85c \uc9c4\ucd9c\uc2dc\ucf30\ub2e4.<\/p>\n

\uc5c5\uacc4 \uc758\uacac \ubc0f \ucd94\uac00 \uc815\ubcf4<\/p>\n

Insilico Medicine \uacfc\ud559 \uc790\ubb38 \uc704\uc6d0\ud68c(SAB)\uc758 Charles Cantor<\/span> \ubc15\uc0ac\ub294 “AI\uc640 \ub525\ub7ec\ub2dd \ubc29\uc2dd\uc774 \ubbf8\ub798 \uc2e0\uc57d \uac1c\ubc1c \uacfc\uc815\uc744 \uadfc\ubcf8\uc801\uc73c\ub85c \ubc14\uafc0 \uac83\uc774\ub77c\ub294 \ub9ce\uc740 \ucd94\uce21\uc774 \uc788\uc5c8\ub2e4. \uc774 \ub17c\ubb38\uc740 \ub9e4\uc6b0 \uc124\ub4dd\ub825 \uc788\ub294 \uac1c\ub150 \uc99d\uba85\uc744 \uc81c\uc2dc\ud55c\ub2e4. \ud45c\uc801 \uc2dd\ubcc4\ubd80\ud130 \ud6c4\ubcf4 \uc57d\ubb3c \uc120\uc815, 1\uc0c1 \uc5f0\uad6c\uae4c\uc9c0 \uac70\uc758 \ubaa8\ub4e0 \ub2e8\uacc4\uc5d0\uc11c AI\ub97c \ud65c\uc6a9\ud574 \uc0c8\ub85c\uc6b4 \ubd84\uc790\uac00 \uc784\uc0c1 2\uc0c1 \uc2dc\ud5d8\uc5d0 \ub4e4\uc5b4\uac08 \uc900\ube44\uac00 \ub410\ub2e4. \uc774 \uacfc\uc815\uc774 \uc77c\ubc18\ud654\ub418\uba74 AI \uc5c6\uc774 \uc2e0\uc57d \uac1c\ubc1c\uc744 \ud558\ub294 \uac83\uc740 \uc0c1\uc0c1\ud560 \uc218 \uc5c6\uac8c \ub420 \uac83”\uc774\ub77c\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

01.AI\uc758 CEO\uc774\uc790 Sinovation Ventures \ud68c\uc7a5\uc778 Kai-Fu Lee\ub294 “\uc758\ub8cc\ub294 \ub514\uc9c0\ud138\ud654\ub77c\ub294 \uc911\uc694\ud55c \ubcc0\uace1\uc810\uc744 \ub9de\uc774\ud558\uace0 \uc788\ub2e4. AI\uc640 \ub370\uc774\ud130 \uacfc\ud559\uc758 \ud65c\uc6a9\uc740 \uc758\ud559 \ubd84\uc57c\uc5d0 \ud601\uba85\uc744 \uc77c\uc73c\ud0ac \uac83\uc774\ub2e4. Insilico Medicine\uc758 TNIK \ud504\ub85c\uadf8\ub7a8\uc740 \ud654\ud559\uacfc \uc0dd\ubb3c\ud559 \ubd84\uc57c\uc5d0\uc11c \uc0dd\uc131\ud615 AI\ub97c \ud65c\uc6a9\ud574 \ucc98\uc74c\ubd80\ud130 \uc2e0\uc57d\uc744 \ubc1c\uacac\ud558\ub294 \ud68d\uae30\uc801\uc778 \ud328\ub7ec\ub2e4\uc784\uc744 \uc81c\uc2dc\ud55c \ud6cc\ub96d\ud55c \uc0ac\ub840\ub2e4. Insilico\uac00 \uac15\ub825\ud55c \uc2e4\ud5d8 \ub370\uc774\ud130\ub97c \ubc14\ud0d5\uc73c\ub85c \ub2ec\uc131\ud55c \uc131\uacfc\ub294 \ucd5c\ucca8\ub2e8 \uc815\ubcf4 \uae30\uc220\uc744 \ud1b5\ud574 \uc0dd\uba85\uacfc\ud559\uc744 \ubc1c\uc804\uc2dc\ud0a4\ub294 \uc62c\ubc14\ub978 \ubc29\ud5a5\uc73c\ub85c \ub098\uc544\uac00\uace0 \uc788\ub2e4\ub294 \uc99d\uac70\uc774\uba70, \uc804\uccb4 \uc0dd\ud0dc\uacc4\uc5d0 \uae0d\uc815\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\uce60 \uac83”\uc774\ub77c\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

2013\ub144 \ub178\ubca8 \ud654\ud559\uc0c1 \uc218\uc0c1\uc790\uc778 Michael Levitt<\/span> \ubc15\uc0ac\ub294 “\ub9ce\uc740 \uae30\uc5c5\uc774 \uc2e0\uc57d \uac1c\ubc1c\uc758 \uc5ec\ub7ec \ub2e8\uacc4\ub97c \uac1c\uc120\ud558\uae30 \uc704\ud574 AI \uc5f0\uad6c\uc5d0 \ud798\uc4f0\uace0 \uc788\uc9c0\ub9cc, Insilico\ub294 \ubaa8\ub4e0 \ucd08\uae30 \uc2e0\uc57d \uac1c\ubc1c \ubc0f \uc124\uacc4 \ub2e8\uacc4\uc5d0 AI\ub97c \uc801\uc6a9\ud558\ub824\ub294 \uc2dc\ub3c4\ub97c \ud558\uace0 \uc788\uc5b4 \ub9e4\uc6b0 \uae30\ub300\ub41c\ub2e4”\uace0 \ud3c9\uac00\ud588\ub2e4. Levitt \ubc15\uc0ac\ub294 “Insilico\ub294 \ub9d0 \uadf8\ub300\ub85c \ucc98\uc74c\ubd80\ud130 \ub05d\uae4c\uc9c0 AI\ub97c \uc0ac\uc6a9\ud558\ub294 \uae30\uc5c5\uc774\ub2e4. \ub2e8\uc21c\ud788 \uc0c8\ub85c\uc6b4 \ud45c\uc801\uc744 \ubc1c\uad74\ud588\uc744 \ubfd0\ub9cc \uc544\ub2c8\ub77c \ucd08\uae30 \uc2e0\uc57d \uac1c\ubc1c \ud504\ub85c\uc138\uc2a4 \uc804\uccb4\ub97c \uac00\uc18d\ud588\uc73c\uba70, TNIK \ud504\ub85c\uadf8\ub7a8\uc5d0\uc11c AI \ubc29\ubc95\uc758 \uc720\ud6a8\uc131\uc744 \uc131\uacf5\uc801\uc73c\ub85c \uac80\uc99d\ud588\ub2e4. \uc2e0\uc57d \uac1c\ubc1c\uc740 \ubd88\ud655\uc2e4\uc131\uc774 \ub9e4\uc6b0 \ub192\uc740 \uad11\ubc94\uc704\ud55c \ud504\ub85c\uc81d\ud2b8\ub2e4. \uadf8\ub7ec\ub098 AI\ub294 \ubc29\ub300\ud55c \uc591\uc758 \ub370\uc774\ud130\uc5d0 \ub300\ud55c \ud2b9\uc815 \uae30\uc220\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \ud65c\uc6a9\ud560 \uc218 \uc788\uc73c\uba70, \uc774\ub97c \ub611\ub611\ud55c \ud544\ud130\ub9c1\uacfc \uacb0\ud569\ud574 \ubd88\ud655\uc2e4\uc131\uc5d0\uc11c \ud655\uc2e4\uc131\uacfc \uc120\ud0dd\uc9c0\ub97c \ud655\ubcf4\ud560 \uc218 \uc788\ub2e4”\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n

\uce94\uc790\uc2a4 \ub300\ud559\uc758 \uc758\uc57d\ud654\ud559 \ubd80\uad50\uc218\uc774\uc790\u00a0AbbVie\uc758 \uc804 \uae00\ub85c\ubc8c \uc758\uc57d\ud654\ud559 \ub9ac\ub354\uc2ed \ud300\uc7a5\uc778 Stevan Djuric<\/span> \ubc15\uc0ac\ub294 “\ucd5c\uadfc AI, \uba38\uc2e0\ub7ec\ub2dd, \uc0dd\uc131\ud615 \ub514\uc790\uc778\uc758 \uae0d\uc815\uc801 \uce21\uba74\uc5d0 \ub300\ud55c \ubcf4\ub3c4\uac00 \ube48\ubc88\ud558\uac8c \uc774\ub904\uc9c0\uace0 \uc788\ub2e4. \ub2e4\uc18c \uacfc\uc7a5\ub41c \ub290\ub08c\ub3c4 \uc788\uc9c0\ub9cc, \uc774\ubc88 \ub17c\ubb38\uc5d0\uc11c Insilico Medicine \ud300\uc740 \uc55e\uc11c \uc5b8\uae09\ud55c \ub3c4\uad6c\ub97c \ud65c\uc6a9\ud574 \ud45c\uc801 \uc2dd\ubcc4 \ubc0f \uac80\uc99d, \uc758\uc57d\ud654\ud559 \uc124\uacc4 \ubc0f \uc784\uc0c1\uc2dc\ud5d8 \uad6c\uc131 \uc694\uc18c\ub97c \ud3ec\ud568\ud558\ub294 \ub3c5\uc810 \ud50c\ub7ab\ud3fc\uc758 \uac15\ub825\ud55c \uc7a0\uc7ac\ub825\uc744 \uba85\ud655\ud558\uac8c \uc99d\uba85\ud588\ub2e4. \uc219\ub828\ub41c \uc758\uc57d\ud654\ud559\uc790\uc5d0\uac8c\ub294 \ud654\ud569\ubb3c\uc758 \ud6a8\ub2a5 \ud5a5\uc0c1\ubcf4\ub2e4 PK(CLu \ub4f1)\uc640 \uc548\uc804\uc131(\ud45c\uc801 \uc678 \ud6a8\uacfc)\uc758 \uc815\ubc00\ud55c \uc870\uc815\uc774 \ub354 \uc911\uc694\ud55c \uacfc\uc81c\uc778 \uacbd\uc6b0\uac00 \ub9ce\ub2e4. \uc774\ubc88 \uc0ac\ub840\uc5d0\uc11c Insilico \uc5d4\uc9c4\uc740 \uc774\ub7ec\ud55c \ubcf5\uc7a1\ud55c \ubb38\uc81c\uc758 \ubaa8\ub4e0 \uc694\uc18c\ub4e4\uc744 \uc801\uc2dc\uc5d0 \uc131\uacf5\uc801\uc73c\ub85c \ud574\uacb0\ud588\ub2e4. \uc774 \uc57d\uc81c\uc758 \ud5a5\ud6c4 \uc9c4\ud589 \uc0c1\ud669\uacfc \uc0dd\uc131\ud615 AI \ud328\ub7ec\ub2e4\uc784\uc744 \ud65c\uc6a9\ud574 \ubc1c\uad74\ub41c \ud6c4\uc18d \uc784\uc0c1 \ud6c4\ubcf4\uad70\uc5d0 \ub300\ud55c \uc18c\uc2dd\uc744 \uae30\ub300\ud55c\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\ud1a0\ub860\ud1a0 \ub300\ud559\uc758 \ud654\ud559, \ucef4\ud4e8\ud130 \uacf5\ud559 \uad50\uc218\uc774\uc790 Acceleration \ucee8\uc18c\uc2dc\uc5c4\uc758 \ucc45\uc784\uc790\uc778 Al\u00e1n Aspuru-Guzik \ubc15\uc0ac\ub294 “\ub9ce\uc740 \uc0ac\ub78c\uc774 \uc2e0\uc57d \uac1c\ubc1c\uc5d0 AI\ub97c \ud65c\uc6a9\ud55c\ub2e4\uace0 \uc8fc\uc7a5\ud558\uc9c0\ub9cc \uc2e4\uc81c\ub85c \uc131\uacfc\ub97c \ubcf4\uc5ec\uc8fc\ub294 \uacf3\uc740 \ub4dc\ubb3c\ub2e4”\uace0 \uc9c0\uc801\ud588\ub2e4. \uadf8\ub7ec\uba74\uc11c “Insilico \ud300\uc740 AI\ub97c \uae30\ubc18\uc73c\ub85c \ud45c\uc801\uc744 \uc2dd\ubcc4\ud558\uace0 \uce58\ub8cc\uc81c\ub97c \uac1c\ubc1c\ud558\ub294 \ub450 \uac00\uc9c0 \ubaa8\ub450\ub97c \uc131\uacf5\uc801\uc73c\ub85c \uc218\ud589\ud588\ub2e4. \ub0b4\uac00 \uc544\ub294 \ubc14\ub85c\ub294 AI\ub85c \uac1c\ubc1c\ub41c \uc57d\ubb3c\uc774 2\uc0c1 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0 \uc9c4\ucd9c\ud55c \uac83\uc740 \uc774\ubc88\uc774 \ucc98\uc74c\uc774\ub2e4. \uc774\ub294 \ucee4\ubba4\ub2c8\ud2f0\uc640 Insilico \ubaa8\ub450\uc5d0\uac8c \uc9c4\uc815\ud55c \uc774\uc815\ud45c\uc774\uba70, \uc5ec\uae30\uc11c \uc5bb\uc740 \uad50\ud6c8\uc744 \ub354\uc6b1 \ud655\uc7a5\ud558\uba74 \uc2e0\uc57d \ubc1c\uad74 \ubc0f \uac1c\ubc1c \uacfc\uc815\uc5d0 \uc18d\ub3c4\ub97c \ub0bc \uc218 \uc788\uc744 \uac83”\uc774\ub77c\uace0 \uae30\ub300\ud588\ub2e4.<\/p>\n

\ub3c5\uc77c \uc758\ud559\uc704\uc6d0\ud68c \uc778\uc99d \uc57d\ub9ac\ud559\uc790\uc774\uc790 \ub3c5\uc131\ud559\uc790\uc774\uba70\u00a0Insilico Medicine\uc758 \uc804\uc784\uc0c1 \ucee8\uc124\ud134\ud2b8\uc778 Klaus Witte<\/span> \ubc15\uc0ac\ub294 “\uc12c\uc720\uc99d \uc9c8\ud658\uc5d0 \ub300\ud55c INS018_055\uc758 \uc804\uc784\uc0c1 \ud504\ub85c\ud30c\uc77c\ub9c1\uc744 \uc2dc\uc791\ud588\uc744 \ub54c \ubaa8\ub450 \uc774 \uc57d\ubb3c\uc758 \ud45c\uc801 TNIK\ub97c \uc885\uc591 \uce58\ub8cc \ud6c4\ubcf4\ubb3c\uc9c8\ub85c \uc0dd\uac01\ud558\uace0 \uc788\uc5c8\ub2e4”\uace0 \ubc1d\ud614\ub2e4. \uadf8\ub294 “\ucc98\uc74c\uc5d0\ub294 \ud68c\uc758\uc801\uc774\uc5c8\uc9c0\ub9cc \uc6b0\ub9ac\uac00 \uc218\uc9d1\ud55c \ubaa8\ub4e0 \ub370\uc774\ud130\ub294 Insilico\uc758 \ud56d\uc12c\uc720\uc99d \ud6a8\ub2a5 \uc608\uce21\uc744 \uba85\ud655\ud558\uac8c \ub4b7\ubc1b\uce68\ud588\ub2e4. \ud604\uc7ac \ud655\ubcf4\ub41c \ubc29\ub300\ud55c \uc804\uc784\uc0c1\u2022\uc784\uc0c1 \ub370\uc774\ud130\ub97c \uc885\ud569\ud574 \ubcf4\uba74, INS018_055\uac00 \ud3d0\uc12c\uc720\uc99d \ubc0f \uae30\ud0c0 \uc12c\uc720\uc99d \uce58\ub8cc\uc5d0 \ub9e4\uc6b0 \uc720\uc6a9\ud55c \uce58\ub8cc \uc635\uc158\uc774 \ub420 \uc218 \uc788\ub2e4\uace0 \ud655\uc2e0\ud55c\ub2e4. \uc774 \ud654\ud569\ubb3c\uc774 \ud604\uc7ac \ub2e8\uacc4\uc5d0 \ub3c4\ub2ec\ud558\ub3c4\ub85d \uae30\uc5ec\ud55c \uac83\uc740 \uc815\ub9d0 \uc790\ub791\uc2a4\ub7fd\ub2e4”\uace0 \ud588\ub2e4.<\/p>\n

\uc544\ud5e8\uacf5\uacfc\ub300\ud559\uad50\uc758 \uc758\uacfc\ud559\uc790\uc778 Christoph Kuppe<\/span> \ubc15\uc0ac\ub294 “\uc784\uc0c1\uc758\ub85c\uc11c \uc0c8\ub85c\uc6b4 \ud6a8\uacfc\uc801\uc778 \uce58\ub8cc\ubc95\uc758 \ud544\uc694\uc131\uc744 \ubab8\uc18c \ub290\ub07c\uace0 \uc788\ub2e4. \uc774 \ud68d\uae30\uc801\uc778 \uc5f0\uad6c\ub294 \ubc1c\uacac\uc5d0\uc11c \uce58\ub8cc\uae4c\uc9c0\uc758 \uacfc\uc815\uc744 \uac00\uc18d\ud558\uace0, \ud604\uc7ac \uce58\ub8cc \uc635\uc158\uc774 \uc81c\ud55c\uc801\uc778 \uc9c8\ubcd1\uc5d0 \ub300\ud55c \uc6b0\ub9ac\uc758 \uc804\ub7b5\uc744 \uc7ac\uad6c\uc131\ud558\ub294 \ub370 AI\uac00 \uc218\ud589\ud560 \uc218 \uc788\ub294 \ud575\uc2ec\uc801\uc778 \uc5ed\ud560\uc744 \uc798 \ubcf4\uc5ec\uc900\ub2e4”\uace0 \ud3c9\uac00\ud588\ub2e4.<\/p>\n

\ub274\uc695\ub300\ud559\uad50 \ucef4\ud4e8\ud130\uacf5\ud559\uacfc \uad50\uc218\uc778\u00a0Bud Mishra \ubc15\uc0ac\ub294 “Alex\uc640 Insilico\uac00 10\ub144 \ub9cc\uc5d0 \uc774\ub8ec \ub180\ub77c\uc6b4 \uc9c4\uc804\uc5d0 \uae4a\uc740 \uac10\uba85\uc744 \ubc1b\uc558\ub2e4. \uc774 \ub17c\ubb38\uc740 \uc5ec\ub7ec \uc720\uc804\uc790 \ub3cc\uc5f0\ubcc0\uc774\uac00 \uad00\ub828\ub41c \ubcf5\uc7a1\ud55c \uc720\uc804\uc801 \ud2b9\uc9d5\uc744 \uac00\uc9c4 \ud2b9\ubc1c\uc131 \ud3d0\uc12c\uc720\uc99d\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd94\uace0 \uc788\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc774 \ubcf5\uc7a1\ud55c \ubb38\uc81c\ub97c \ub450 \ub2e8\uacc4\ub85c \ub098\ub220 \ud574\uacb0\ud588\ub2e4. \uba3c\uc800 \ud45c\uc801(TNIK)\uc744 \uc120\ud0dd\ud558\uace0 \ud574\ub2f9 \ud45c\uc801\uc5d0 \uacb0\ud569\ud574 \uae30\ub2a5\uc744 \uc800\ud558\ud558\ub294 \uc800\ubd84\uc790 \ud654\ud569\ubb3c\uc744 \uc124\uacc4\ud574 \uc2e0\uc57d \uac1c\ubc1c \uacfc\uc815\uc744 \uc548\ub0b4\ud588\ub2e4”\uace0 \ubc1d\ud614\ub2e4. \uadf8\ub294 “\uccab \ubc88\uc9f8 \ub2e8\uacc4\ub294 \uacfc\uac70 \uacfc\ud559\uc801 \uacbd\ud5d8\uc5d0 \uae30\ubc18\ud55c \ud734\ub9ac\uc2a4\ud2f1(\ud45c\uc801\uc740 \uc0c8\ub86d\uace0, \uc54c\ub824\uc9c4 \uacbd\ub85c\uc640\uc758 \uc0c1\ud638 \uc791\uc6a9\uc744 \uc774\ud574\ud558\uae30 \uc26c\uc6b0\uba70, \uacfc\uac70 \ub2e4\ub978 \uc0ac\ub78c\ub4e4\uc774 \uc2e0\uc57d \uac1c\ubc1c \ubc0f \uc784\uc0c1 \uc2dc\ud5d8\uc744 \uc548\ub0b4\ud558\ub294 \ub370 \uc0ac\uc6a9\ud55c \uc811\uadfc \ubc29\uc2dd\uc744 \ub530\ub77c\uc57c \ud568)\uc744 \uc0ac\uc6a9\ud558\uba70, \uc774\ub294 LLM\uc744 \uc0ac\uc6a9\ud558\ub294 NLP\uc5d0 \uc774\uc0c1\uc801”\uc774\ub77c\uace0 \uc124\uba85\ud588\ub2e4. \uc774\uc5b4 “\ub450 \ubc88\uc9f8 \ub2e8\uacc4\ub294 \ubb34\uc791\uc704 \ud734\ub9ac\uc2a4\ud2f1\uc744 \uc0ac\uc6a9\ud574 DNN\uc73c\ub85c \ubcf5\uc7a1\ud55c \uc870\ud569 \uacf5\uac04\uc744 \uac80\uc0c9\ud558\uace0 \ucd5c\uc801\ud654\ud558\uba70, \uc790\uc5f0\uc801\uc73c\ub85c \ubc1c\uc0dd\ud558\ub294 ‘\uc5b4\ub824\uc6b4 \ubb38\uc81c\uc758 \uc26c\uc6b4 \uc778\uc2a4\ud134\uc2a4’\ub97c \ucc98\ub9ac\ud560 \uc218 \uc788\ub2e4. \uc2dc\uac04\uc774 \uc9c0\ub0a0\uc218\ub85d \uccab \ubc88\uc9f8 \ub2e8\uacc4\ub294 \ub354 \uc5b4\ub824\uc6cc\uc9c0\uace0 (\ud658\uc601 vs. \uc9c4\uc815\ud55c \uc2e0\uae30\uc131), \ub450 \ubc88\uc9f8 \ub2e8\uacc4\ub294 \ub354 \uac04\ub2e8\ud574\uc9c8 \uac83\uc774\ub2e4. \ubb34\uc5b4\uc758 \ubc95\uce59\uc5d0 \ub530\ub77c \uacc4\uc0b0 \ub2a5\ub825\uc774 \uae30\ud558\uae09\uc218\uc801\uc73c\ub85c \ud5a5\uc0c1\ub420 \uac83\uc774\uae30 \ub54c\ubb38”\uc774\ub77c\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n

\ucc38\uace0
Ren, F., et al. A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models. Nat Biotechnol (2024). https:\/\/doi.org\/10.1038\/s41587-024-02143-0<\/a><\/p>\n

Insilico Medicine \uc18c\uac1c<\/p>\n

InSilico Medicine\uc740 \uc0dd\uc131\ud615 AI\ub97c \uac16\ucd98 \uad6d\uc81c \uc784\uc0c1 \ub2e8\uacc4 \uc0dd\uba85\uacf5\ud559 \ud68c\uc0ac\ub85c \ucc28\uc138\ub300 AI \uc2dc\uc2a4\ud15c\uc744 \uc0ac\uc6a9\ud574 \uc0dd\ubb3c\ud559, \ud654\ud559, \uc784\uc0c1\uc2dc\ud5d8\uc744 \uc5f0\uacb0\ud55c\ub2e4. InSilico Medicine\uc740 \uc0c8\ub85c\uc6b4 \ud45c\uc801\uc744 \ubc1c\uacac\ud558\uace0 \uc6d0\ud558\ub294 \uc18d\uc131\uc758 \uc0c8\ub85c\uc6b4 \ubd84\uc790 \uad6c\uc870\ub97c \uc0dd\uc131\ud558\uae30 \uc704\ud574 \ub525 \uc0dd\uc131 \ubaa8\ub378, \uac15\ud654 \ud559\uc2b5, \ubcc0\ud658\uae30 \ubc0f \uae30\ud0c0 \ud604\ub300\uc2dd \uba38\uc2e0 \ub7ec\ub2dd \uae30\uc220\uc744 \uc774\uc6a9\ud558\ub294 AI \ud50c\ub7ab\ud3fc\uc744 \uac1c\ubc1c\ud588\ub2e4. \ud604\uc7ac InSilico Medicine\uc740 \uc554, \uc12c\uc720\uc99d, \uba74\uc5ed, \uc911\ucd94\uc2e0\uacbd\uacc4 \uc9c8\ud658, \uac10\uc5fc \uc9c8\ud658, \uc790\uac00\uba74\uc5ed \uc9c8\ud658 \ubc0f \ub178\ud654 \uad00\ub828 \uc9c8\ud658\uc5d0 \ub300\ud55c \ud601\uc2e0\uc801\uc778 \uc57d\ubb3c\uc744 \ubc1c\uacac\ud558\uace0 \uac1c\ubc1c\ud558\ub294 \ud68d\uae30\uc801\uc778 \uc194\ub8e8\uc158\uc744 \uac1c\ubc1c\ud558\uace0 \uc788\ub2e4. www.Insilico.com<\/a><\/p>\n

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