{"id":22002,"date":"2024-08-09T01:19:23","date_gmt":"2024-08-08T16:19:23","guid":{"rendered":"http:\/\/mhjn.dothome.co.kr\/%ed%8e%98%ed%94%84%eb%a1%9c%eb%af%bc-%eb%b0%94%ec%9d%b4%ec%98%a4-%ec%83%88%eb%a1%9c%ec%9a%b4-%ed%82%a4%eb%a9%94%eb%9d%bc-%ed%95%ad%ec%9b%90-%ec%88%98%ec%9a%a9%ec%b2%b4car-t%ec%84%b8%ed%8f%ac\/"},"modified":"2024-08-09T01:19:23","modified_gmt":"2024-08-08T16:19:23","slug":"%ed%8e%98%ed%94%84%eb%a1%9c%eb%af%bc-%eb%b0%94%ec%9d%b4%ec%98%a4-%ec%83%88%eb%a1%9c%ec%9a%b4-%ed%82%a4%eb%a9%94%eb%9d%bc-%ed%95%ad%ec%9b%90-%ec%88%98%ec%9a%a9%ec%b2%b4car-t%ec%84%b8%ed%8f%ac","status":"publish","type":"post","link":"http:\/\/mhjn.dothome.co.kr\/en\/%ed%8e%98%ed%94%84%eb%a1%9c%eb%af%bc-%eb%b0%94%ec%9d%b4%ec%98%a4-%ec%83%88%eb%a1%9c%ec%9a%b4-%ed%82%a4%eb%a9%94%eb%9d%bc-%ed%95%ad%ec%9b%90-%ec%88%98%ec%9a%a9%ec%b2%b4car-t%ec%84%b8%ed%8f%ac\/","title":{"rendered":"\ud398\ud504\ub85c\ubbfc \ubc14\uc774\uc624, \uc0c8\ub85c\uc6b4 \ud0a4\uba54\ub77c \ud56d\uc6d0 \uc218\uc6a9\uccb4(CAR) T\uc138\ud3ec\uc758 \uac15\ub825\ud55c \ub2e4\uae30\ub2a5\uc131\uc744 \uc785\uc99d\ud55c \uc5f0\uad6c \uacb0\uacfc \ubc1c\ud45c"},"content":{"rendered":"

\ub2e4\uae30\ub2a5\uc131\uc740<\/span> CAR T \uc138\ud3ec \uce58\ub8cc\ub97c \ud1b5\ud574 \ud658\uc790\uc758 \ucc28\ub3c4\uac00 18\uac1c\uc6d4 \uc774\uc0c1 \uc9c0\uc18d\ub418\ub294 \uac83\uacfc \uad00\ub828\uc774 \uc788\ub2e4<\/span><\/p>\n

\uc5b4\ubc14\uc778, \uce98\ub9ac\ud3ec\ub2c8\uc544<\/span>, 2024\ub144 8\uc6d4 9\uc77c<\/span> \/PRNewswire\/ — \uc554\uacfc \uba74\uc5ed \uc7a5\uc560\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc744 \uac1c\ubc1c\ud558\ub294 \uc784\uc0c1 \ub2e8\uacc4 \ubc14\uc774\uc624\ud14d \uae30\uc5c5 \ud398\ud504\ub85c\ubbfc \ubc14\uc774\uc624(PeproMene Bio, Inc.<\/span><\/a>)\ub294 \uc2dc\ud2f0 \uc624\ube0c \ud638\ud504(City of Hope)\uac00 \uac1c\ubc1c\ud588\uc73c\uba70 PMB-CT01\ub85c \uc54c\ub824\uc9c4 BAFF-R CAR T\uac00 \ud604\uc7ac \uc2dd\ud488\uc758\uc57d\uad6d \uc2b9\uc778 CAR T\uc138\ud3ec \uce58\ub8cc\ubc95\uc5d0 \uc0ac\uc6a9\ub418\ub294 CD19 CAR T\uc138\ud3ec\ubcf4\ub2e4 \ub354 \ub098\uc740 \ub2e4\uae30\ub2a5\uc131\uc744 \uc785\uc99d\ud588\ub2e4\uace0 \uc624\ub298 \ube14\ub7ec\ub4dc \uc5b4\ub4dc\ubc34\uc2dc\uc988(Blood Advances<\/span><\/a>)\uc5d0\uc11c \ubc1c\uac04\ub41c \uc0c1\uad00 \uc5f0\uad6c\uc5d0 \ub530\ub77c \ubc1c\ud45c\ud588\ub2e4.<\/span><\/p>\n

\uc5f0\uad6c\uc9c4\uc740 \ub2e8\uc138\ud3ec \ud50c\ub7ab\ud3fc\uc744 \uc774\uc6a9\ud574<\/span> PMB-CT01 CAR T\uc138\ud3ec\uac00 CD 19 CAR T\uc138\ud3ec\ubcf4\ub2e4 \uc5ec\ub7ec \uae30\ub2a5\uc744 \ub3d9\uc2dc\uc5d0 \uc218\ud589\ud560 \uc218 \uc788\ub294 T\uc138\ud3ec\uc758 \ub2a5\ub825\uc778 \ub2e4\uae30\ub2a5\uc131\uc774 \ub354 \ub192\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\ub2e4. PMB-CT01 \uc138\ud3ec\ub294 \uba74\uc5ed\uacc4\ub97c \uac15\ud654\ud560 \uc218 \uc788\ub294 \uc790\uadf9\uc131 \uc0ac\uc774\ud1a0\uce74\uc778\uacfc \uc554\uc138\ud3ec\ub97c \uc9c1\uc811 \uc8fd\uc77c \uc218 \uc788\ub294 \uc774\ud399\ud130 \uc0ac\uc774\ud1a0\uce74\uc778\ub3c4 \ub354 \ub9ce\uc774 \uc0dd\uc0b0\ud588\ub2e4.<\/span><\/p>\n

\uc5f0\uad6c\uc9c4\uc740 \uc2dc\ud2f0 \uc624\ube0c \ud638\ud504\uac00 \uac1c\ubc1c\ud55c \uac80\uc0ac\ubc95\uc744 \uc774\uc6a9\ud574 \uc7ac\ubc1c\uc131 \ub9e8\ud2c0 \uc138\ud3ec \ub9bc\ud504\uc885\uc744 \uac00\uc9c4<\/span> 57\uc138 \ub0a8\uc131\uc758 BAFF-R CAR T\uc138\ud3ec \uc81c\ud488\uc744 \ud14c\uc2a4\ud2b8\ud588\ub2e4. \uc774 \ud658\uc790\ub294 \uc774\uc804\uc758 CD19 CAR T\uc138\ud3ec \uce58\ub8cc\ubc95\uc73c\ub85c\ub294 \ucc28\ub3c4\ub97c \ubcf4\uc774\uc9c0 \ubabb\ud588\ub2e4. \uc774 \ub0a8\uc131\uc740 \uc2dc\ud2f0 \uc624\ube0c \ud638\ud504\uc758 1<\/span>\uc0c1 \uc2dc\ud5d8<\/span><\/a>\uc5d0\uc11c PMB-CT01\uc744 \uc0ac\uc6a9\ud558\uc5ec \ud55c \ubc88 \uc8fc\uc785\uc744 \ubc1b\uc558\ub294\ub370 \ucd5c\uc18c\ud55c\uc758 \ubd80\uc791\uc6a9\ub9cc\uc744 \uacbd\ud5d8\ud55c \ud6c4 18\uac1c\uc6d4 \uc774\uc0c1 \uc644\uc804\ud55c \ucc28\ub3c4\ub97c \ubcf4\uc774\uace0 \uc788\uc73c\uba70 \ucd5c\uc18c \uc794\uc5ec \uc9c8\ud658\uc5d0 \ub300\ud55c \ubd84\uc790 \ubbfc\uac10\ub3c4 \uac80\uc0ac \uacb0\uacfc \uc554 \uc138\ud3ec\ub97c \ubc1c\uacac\ud560 \uc218 \uc5c6\ub294 \uc0c1\ud0dc\uac00 \uc9c0\uc18d\ub418\uace0 \uc788\ub2e4. <\/span><\/p>\n

\uc774 \uc5f0\uad6c\ub294 \uc8fc\uc785 \uc774\ud6c4<\/span> CAR T\uc138\ud3ec\uc758 \uc131\uacf5\uc801\uc778 \ud655\uc7a5 \ubc0f \ud658\uc790\uc758 \uc9c0\uc18d\uc801\uc778 \ucc28\ub3c4\uc640 \uc0c1\uad00<\/span> \uad00\uacc4\uac00 \uc788\ub294 \ub2e4\uae30\ub2a5\uc131\uc758 \uac15\ub825\ud55c \uc9c0\ud45c\ub97c \ubcf4\uace0\ud588\ub2e4<\/span>. \uc5f0\uad6c\uc9c4\uc740 \uc774 \ubd84\uc11d \uae30\ubc95\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc784\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c PMB-CT01\uacfc \uc720\uc0ac\ud55c \ucc28\ub3c4\ub97c \ubcf4\uc778 \ub2e4\ub978 \ud658\uc790 5 \uba85\uc758 CAR T\uc138\ud3ec \uc81c\ud488\uc744 \ud14c\uc2a4\ud2b8\ud560 \uacc4\ud68d\uc774\ub2e4.<\/span><\/p>\n

\uc2dc\ud2f0 \uc624\ube0c \ud638\ud504\uc758 \uc885\ud569 \uc554 \uc13c\ud130 \ubd80\uc6d0\uc7a5 \uacb8 \ubd80\uc18c\uc7a5\uc774\uc790 \ud398\ud504\ub85c\ubbfc\uc758 \uacfc\ud559 \uc124\ub9bd\uc790 \uacb8 \uacfc\ud559 \uc790\ubb38 \uc704\uc6d0\ud68c\uc758 \ubcf4\uc0c1 \uc758\uc7a5 \ub798\ub9ac<\/span> W. \uacfd(Larry W. Kwak<\/span><\/span><\/a>) M.D., Ph.D.\ub294 “\uc6b0\ub9ac\ub294 \uc0c1\uc5c5\uc6a9 CD19 CAR T\uc138\ud3ec \uce58\ub8cc\ub97c \ubc1b\uc740 \ud6c4 \uc7ac\ubc1c\ud558\ub294 \ub9bc\ud504\uc885 \ubc0f \ubc31\ud608\ubcd1 \ud658\uc790\uc758 \ub610 \ub2e4\ub978 \ud558\ub098\uc758 \uce58\ub8cc \uc635\uc158\uc73c\ub85c BAFFR-CAR T \uce58\ub8cc\ubc95\uc744 \uac1c\ubc1c\ud588\uc73c\uba70, \uc9c0\uae08\uae4c\uc9c0\uc758 \uacb0\uacfc\ub294 \ub3c5\uc131\uc744 \ucd5c\uc18c\ud654\ud558\ub294 \uc774\uc0c1\uc801\uc778 \ucd5c\ub300 \ud6a8\ub2a5\uc744 \ubcf4\uc778\ub2e4”\uace0 \ub9d0\ud588\ub2e4. \uacfd\uc740 \ud398\ud504\ub85c\ubbfc\uc758 \uc8fc\uc2dd \uc9c0\ubd84\uc744 \uac00\uc9c0\uace0 \uc788\ub2e4. \uadf8\ub294 “\uc6b0\ub9ac\ub294 \ud658\uc790 \uacb0\uacfc\ub97c \uc608\uce21\ud558\uace0 \ud6a8\uacfc\uc801\uc778 CAR T\uc138\ud3ec \uce58\ub8cc\ubc95\uc758 \uac1c\ubc1c\uc744 \uac00\uc18d\ud560 \uc218 \uc788\ub294 \ub2a5\ub825\uc744 \uac00\uc9c4 CAR T\uc138\ud3ec \uc81c\ud488\uc5d0 \ub300\ud55c \uac15\ub825\ud558\uace0 \uc2e0\ub8b0\ud560 \uc218 \uc788\ub294 \ub2e4\uae30\ub2a5 \ubd84\uc11d \uae30\ubc95\uc744 \uac1c\ubc1c\ud588\ub2e4”\uace0 \ub367\ubd99\uc600\ub2e4. <\/span><\/p>\n

\ubcf8 \uc784\uc0c1\uc2dc\ud5d8\uc758 \uc218\uc11d \uc870\uc0ac\uad00 \uacb8 \ud608\uc561\ud559 \ubc0f \uc870\ud608 \uc138\ud3ec \uc774\uc2dd \ub2f4\ub2f9 \ubd80\uad50\uc218\uc774\uc790 \uc2dc\ud2f0 \uc624\ube0c \ud638\ud504\uc758 \uba74\uc5ed \uc774\ud329\ud130 \uc138\ud3ec \uce58\ub8cc \ud504\ub85c\uadf8\ub7a8\uc758 \uc218\uc11d \uc758\ub8cc \ucc45\uc784\uc790\uc778 \uc5d8\ub9ac\uc790\ubca0\uc2a4 \ubc84\ub4dc<\/span>(Elizabeth Budde<\/span>) \ubc15\uc0ac\uac00 2023\ub144 12\uc6d4 \ubbf8\uad6d \ud608\uc561\ud559\ud68c \ucee8\ud37c\ub7f0\uc2a4\uc5d0\uc11c \ucd08\uae30 \uc784\uc0c1 \uc2dc\ud5d8 \uacb0\uacfc\ub97c \ubc1c\ud45c\ud588\ub2e4.<\/span><\/p>\n

\ubc84\ub4dc \ubc15\uc0ac\ub294<\/span> “\ube44\ud638\uc9c0\ud0a8 \ub9bc\ud504\uc885 \ud658\uc790 5\uba85\uacfc B\uc138\ud3ec \uae09\uc131 \ub9bc\ud504\uad6c\uc131 \ubc31\ud608\ubcd1 \ud658\uc790 1\uba85\uc774 PMB-CT01 \uce58\ub8cc\ub97c \ubc1b\uc558\ub294\ub370 \uadf8\ub4e4 100%\uac00 \uc9c0\uc18d\uc801\uc778 \ubc18\uc751\uc744 \ubcf4\uc600\ub2e4\ub294 \uac83\uc740 \ub180\ub77c\uc6b4 \uc77c”\uc774\ub77c\uba74\uc11c “CD19 CAR T \uce58\ub8cc \ud6c4 \uc7ac\ubc1c\ud55c \uc784\uc0c1 \uc2dc\ud5d8 \ud658\uc790\ub4e4 \uc911 \ub9ce\uc740 \uc218\uac00 CD19 \uc74c\uc131\uc774\uc5c8\ub2e4. PMB-CT01\uc740 \uc774 \ub51c\ub808\ub9c8\uc5d0 \uc9c1\uba74\ud55c \ub2e4\ub978 \ud658\uc790\ub4e4\uc5d0\uac8c\ub3c4 \uc2e4\ud589 \uac00\ub2a5\ud55c \uc635\uc158\uc744 \uc81c\uc2dc\ud560 \uc218 \uc788\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/span><\/p>\n

\ud398\ud504\ub85c\ubbfc \ubc14\uc774\uc624\uc758<\/span> COO \ud5e4\uc774\uc990 \uccad( Hazel Cheng<\/span>) \ubc15\uc0ac\ub294 “\uc774 \ubd84\uc11d \uae30\ubc95\uc740 PMB-CT01\uc758 \uac1c\ubc1c\uc744 \uac00\uc774\ub4dc\ud558\uae30 \uc704\ud574 \ud604\uc7ac \ubc0f \ubbf8\ub798\uc758 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0 \uc801\uc6a9\ub420 \uc218 \uc788\ub2e4”\uba74\uc11c “\ud398\ud2b8\ub85c\ubbfc\uc740 \uc7a0\uc7ac\uc801\uc73c\ub85c \uc720\ub9dd\ud55c \uc0c8\ub85c\uc6b4 \uc138\ud3ec \uce58\ub8cc\ubc95\uc758 \uc9c0\uc18d\uc801\uc778 \uacfc\ud559 \ubc0f \uc784\uc0c1\uc801 \uac1c\ubc1c\uc5d0 \uafb8\uc900\ud788 \uc804\ub150\ud558\uace0 \uc788\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/span><\/p>\n

PMB-CT01<\/span><\/p>\n

PMB-CT01\uc740 \ub3d9<\/span>\uc885<\/span> \ucd5c\ucd08\uc758<\/span> BAFFR \ud45c\uc801 \uc790\uac00 CAR T\uc138\ud3ec \uce58\ub8cc\ubc95\uc774\ub2e4.<\/span>\u00a0 <\/span>\uc885\uc591 \uad34\uc0ac \uc778\uc790<\/span> (TNF) \uc218\uc6a9\uccb4 \uc288\ud37c\ud328\ubc00<\/span>\ub9ac\uc758 \uc77c\uc6d0\uc778 <\/span>BAFF-R (B \uc138\ud3ec \ud65c\uc131 \uc778\uc790 \uc218\uc6a9\uccb4)\uc740 B \uc138\ud3ec\uc5d0\uc11c\ub9cc \uac70\uc758 \ub3c5\uc810\uc801\uc73c\ub85c \ubc1c\ud604\ub418\ub294 BAFF\uc758 \uc8fc\uc694 \uc218\uc6a9\uccb4\uc774\ub2e4.<\/span> BAFF-R \uc2e0\ud638 \uc804\ub2ec\uc740 \uc815\uc0c1\uc801\uc778 B \uc138\ud3ec \uc99d\uc2dd\uc744 \ucd09\uc9c4\ud558\uace0 B \uc138\ud3ec \uc0dd\uc874\uc5d0 \ud544\uc694\ud55c \uac83\uc73c\ub85c \ubcf4\uc774\uae30 \ub54c\ubb38\uc5d0 \uc885\uc591 \uc138\ud3ec\uac00 BAFF-R \ud56d\uc6d0\uc758 \uc190\uc2e4\uc744 \ud1b5\ud574 <\/span>\uce58\ub8cc\uc81c\ub97c<\/span> \ud53c\ud560 <\/span>\uac00\ub2a5\uc131\uc740 \uc801<\/span>\ub2e4<\/span>. \uc774\ub7ec\ud55c \ub3c5\ud2b9\ud55c \ud2b9\uc131\uc740 BAFFR-CAR T \uce58\ub8cc\ubc95\uc744 B \uc138\ud3ec \uc545\uc131 \uc885\uc591\uc758 <\/span>\uc544\uc8fc \uc720\ub9dd\ud55c <\/span>\uce58\ub8cc<\/span> \uc635\uc158<\/span>\uc73c\ub85c \ub9cc\ub4e0\ub2e4<\/span>.<\/span> BAFFR-CAR T\ub294 \ud56d-BAFFR <\/span>\ub2e8\uc77c \uc0ac\uc2ac \ub2e8\ud3b8 \uac00\ubcc0<\/span>(<\/span>scFv<\/span>) \ud56d\uccb4<\/span>\uc640 <\/span>2\uc138\ub300 \uc2e0\ud638 \ub3c4\uba54\uc778\uc778 <\/span>CD3 \u03b6\uc640 <\/span>4-1BB<\/span>\ub97c <\/span>\uc0ac\uc6a9\ud558\uc5ec \uad6c\uc131\ub418\uc5c8\ub2e4<\/span>.<\/span> \uc6b0\ub9ac\uc758 \uc5f0\uad6c\ub97c \ud1b5\ud574<\/span>\u00a0 BAFFR-CAR T\uc138\ud3ec\uac00 \ub3d9\ubb3c \ubaa8\ub378<\/span>\uacfc<\/span> \uc2dc\ud5d8\uad00 \ub0b4<\/span> \ub458 \ubaa8\ub450\uc5d0\uc11c <\/span>\uc778\uac04 \ub9bc\ud504\uc885\uacfc \ubc31\ud608\ubcd1\uc744 <\/span>\ud6a8\uacfc\uc801\uc73c\ub85c <\/span>\uc8fd<\/span>\uc778\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc785\uc99d\ud588\ub2e4<\/span>.<\/span> \ud398\ud504\ub85c\ubbfc\uc740 \uc2dc\ud2f0<\/span> \uc624\ube0c<\/span> \ud638\ud504\ub85c\ubd80\ud130<\/span> PMB-CT01<\/span>\uc758 <\/span>\uc9c0\uc801 \uc7ac\uc0b0\uad8c\uc744 \ub77c\uc774\uc120\uc2a4 \ubc1b\uc558\ub2e4<\/span>.<\/span>\u00a0<\/span><\/p>\n

\ud398\ud504\ub85c\ubbfc \ubc14\uc774\uc624<\/span><\/p>\n

\ud398\ud504\ub85c\ubbfc <\/span>\ubc14\uc774\uc624\ub294 <\/span>\uc554\uacfc \uba74\uc5ed\uc9c8\ud658\uc744 \uce58\ub8cc\ud558\uae30 \uc704\ud55c \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc744 \uac1c\ubc1c\ud558\ub294 \uce98\ub9ac\ud3ec\ub2c8\uc544 \uc5b4\ubc14\uc778\uc758 \uc784\uc0c1 \ub2e8\uacc4 \ubc14\uc774\uc624\ud14d \uae30\uc5c5\uc774\ub2e4<\/span>. \ud398\ud504\ub85c\ubbfc\uc758 \ub9ac\ub4dc \ud6c4\ubcf4\uc778 PMB-CT01(BAFFR-CAR T \uc138\ud3ec)\uc740 \ud604\uc7ac \uc7ac\ubc1c\uc131 \ubc0f \ub09c\uce58\uc131 B\uc138\ud3ec \uae09\uc131 \ub9bc\ud504\uad6c\uc131 \ubc31\ud608\ubcd1(B-ALL; NCT04690595)\uacfc B\uc138\ud3ec \ube44\ud638\uc9c0\ud0a8 \ub9bc\ud504\uc885(B-NHL; NCT05370430)\uc744 \uc784\uc0c1 1\uc0c1\uc5d0\uc11c \uce58\ub8cc\ud558\uae30 \uc704\ud574 \uc5f0\uad6c \uc911\uc774\ub2e4. \ud398\ud504\ub85c\ubbfc \ubc14\uc774\uc624\ub294 \ub610\ud55c BAFFR \uc774\uc911\ud2b9\uc774\uc131 T \uc138\ud3ec \uad00\uc5ec\uccb4\uc640 BAFFR-CAR NK \uc138\ud3ec\ub97c \uac1c\ubc1c\ud558\uace0 \uc788\ub2e4.<\/span><\/p>\n

\uc5f0\ub77d\ucc98<\/span>: John Fry,\u00a0john.fry@pepromenebio.com<\/span><\/a><\/span><\/p>\n

\ub85c\uace0<\/span> –\u00a0https:\/\/mma.prnasia.com\/media2\/1972356\/4847154\/Pepromene_Bio_Inc__Logo.jpg?p=medium600<\/span><\/a><\/span><\/p>\n

\u00a0<\/p>","protected":false},"excerpt":{"rendered":"

<\/p>\n

\ub2e4\uae30\ub2a5\uc131\uc740<\/span> CAR T \uc138\ud3ec \uce58\ub8cc\ub97c \ud1b5\ud574 \ud658\uc790\uc758 \ucc28\ub3c4\uac00 18\uac1c\uc6d4 \uc774\uc0c1 \uc9c0\uc18d\ub418\ub294 \uac83\uacfc \uad00\ub828\uc774 \uc788\ub2e4<\/span><\/p>\n

\uc5b4\ubc14\uc778, \uce98\ub9ac\ud3ec\ub2c8\uc544<\/span>, 2024\ub144 8\uc6d4 9\uc77c<\/span> \/PRNewswire\/ — \uc554\uacfc \uba74\uc5ed \uc7a5\uc560\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc744 \uac1c\ubc1c\ud558\ub294 \uc784\uc0c1 \ub2e8\uacc4 \ubc14\uc774\uc624\ud14d \uae30\uc5c5 \ud398\ud504\ub85c\ubbfc \ubc14\uc774\uc624(PeproMene Bio, Inc.<\/span><\/a>)\ub294 \uc2dc\ud2f0 \uc624\ube0c \ud638\ud504(City of Hope)\uac00 \uac1c\ubc1c\ud588\uc73c\uba70 PMB-CT01\ub85c \uc54c\ub824\uc9c4 BAFF-R CAR T\uac00 \ud604\uc7ac \uc2dd\ud488\uc758\uc57d\uad6d \uc2b9\uc778 CAR T\uc138\ud3ec \uce58\ub8cc\ubc95\uc5d0 \uc0ac\uc6a9\ub418\ub294 CD19 CAR T\uc138\ud3ec\ubcf4\ub2e4 \ub354 \ub098\uc740 \ub2e4\uae30\ub2a5\uc131\uc744 \uc785\uc99d\ud588\ub2e4\uace0 \uc624\ub298 \ube14\ub7ec\ub4dc \uc5b4\ub4dc\ubc34\uc2dc\uc988(Blood Advances<\/span><\/a>)\uc5d0\uc11c \ubc1c\uac04\ub41c \uc0c1\uad00 \uc5f0\uad6c\uc5d0 \ub530\ub77c \ubc1c\ud45c\ud588\ub2e4.<\/span><\/p>\n

\uc5f0\uad6c\uc9c4\uc740 \ub2e8\uc138\ud3ec \ud50c\ub7ab\ud3fc\uc744 \uc774\uc6a9\ud574<\/span> PMB-CT01 CAR T\uc138\ud3ec\uac00 CD 19 CAR T\uc138\ud3ec\ubcf4\ub2e4 \uc5ec\ub7ec \uae30\ub2a5\uc744 \ub3d9\uc2dc\uc5d0 \uc218\ud589\ud560 \uc218 \uc788\ub294 T\uc138\ud3ec\uc758 \ub2a5\ub825\uc778 \ub2e4\uae30\ub2a5\uc131\uc774 \ub354 \ub192\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\ub2e4. PMB-CT01 \uc138\ud3ec\ub294 \uba74\uc5ed\uacc4\ub97c \uac15\ud654\ud560 \uc218 \uc788\ub294 \uc790\uadf9\uc131 \uc0ac\uc774\ud1a0\uce74\uc778\uacfc \uc554\uc138\ud3ec\ub97c \uc9c1\uc811 \uc8fd\uc77c \uc218 \uc788\ub294 \uc774\ud399\ud130 \uc0ac\uc774\ud1a0\uce74\uc778\ub3c4 \ub354 \ub9ce\uc774 \uc0dd\uc0b0\ud588\ub2e4.<\/span><\/p>\n

\uc5f0\uad6c\uc9c4\uc740 \uc2dc\ud2f0 \uc624\ube0c \ud638\ud504\uac00 \uac1c\ubc1c\ud55c \uac80\uc0ac\ubc95\uc744 \uc774\uc6a9\ud574 \uc7ac\ubc1c\uc131 \ub9e8\ud2c0 \uc138\ud3ec \ub9bc\ud504\uc885\uc744 \uac00\uc9c4<\/span> 57\uc138 \ub0a8\uc131\uc758 BAFF-R CAR T\uc138\ud3ec \uc81c\ud488\uc744 \ud14c\uc2a4\ud2b8\ud588\ub2e4. \uc774 \ud658\uc790\ub294 \uc774\uc804\uc758 CD19 CAR T\uc138\ud3ec \uce58\ub8cc\ubc95\uc73c\ub85c\ub294 \ucc28\ub3c4\ub97c \ubcf4\uc774\uc9c0 \ubabb\ud588\ub2e4. \uc774 \ub0a8\uc131\uc740 \uc2dc\ud2f0 \uc624\ube0c \ud638\ud504\uc758 1<\/span>\uc0c1 \uc2dc\ud5d8<\/span><\/a>\uc5d0\uc11c PMB-CT01\uc744 \uc0ac\uc6a9\ud558\uc5ec \ud55c \ubc88 \uc8fc\uc785\uc744 \ubc1b\uc558\ub294\ub370 \ucd5c\uc18c\ud55c\uc758 \ubd80\uc791\uc6a9\ub9cc\uc744 \uacbd\ud5d8\ud55c \ud6c4 18\uac1c\uc6d4 \uc774\uc0c1 \uc644\uc804\ud55c \ucc28\ub3c4\ub97c \ubcf4\uc774\uace0 \uc788\uc73c\uba70 \ucd5c\uc18c \uc794\uc5ec \uc9c8\ud658\uc5d0 \ub300\ud55c \ubd84\uc790 \ubbfc\uac10\ub3c4 \uac80\uc0ac \uacb0\uacfc \uc554 \uc138\ud3ec\ub97c \ubc1c\uacac\ud560 \uc218 \uc5c6\ub294 \uc0c1\ud0dc\uac00 \uc9c0\uc18d\ub418\uace0 \uc788\ub2e4. <\/span><\/p>\n

\uc774 \uc5f0\uad6c\ub294 \uc8fc\uc785 \uc774\ud6c4<\/span> CAR T\uc138\ud3ec\uc758 \uc131\uacf5\uc801\uc778 \ud655\uc7a5 \ubc0f \ud658\uc790\uc758 \uc9c0\uc18d\uc801\uc778 \ucc28\ub3c4\uc640 \uc0c1\uad00<\/span> \uad00\uacc4\uac00 \uc788\ub294 \ub2e4\uae30\ub2a5\uc131\uc758 \uac15\ub825\ud55c \uc9c0\ud45c\ub97c \ubcf4\uace0\ud588\ub2e4<\/span>. \uc5f0\uad6c\uc9c4\uc740 \uc774 \ubd84\uc11d \uae30\ubc95\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc784\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c PMB-CT01\uacfc \uc720\uc0ac\ud55c \ucc28\ub3c4\ub97c \ubcf4\uc778 \ub2e4\ub978 \ud658\uc790 5 \uba85\uc758 CAR T\uc138\ud3ec \uc81c\ud488\uc744 \ud14c\uc2a4\ud2b8\ud560 \uacc4\ud68d\uc774\ub2e4.<\/span><\/p>\n

\uc2dc\ud2f0 \uc624\ube0c \ud638\ud504\uc758 \uc885\ud569 \uc554 \uc13c\ud130 \ubd80\uc6d0\uc7a5 \uacb8 \ubd80\uc18c\uc7a5\uc774\uc790 \ud398\ud504\ub85c\ubbfc\uc758 \uacfc\ud559 \uc124\ub9bd\uc790 \uacb8 \uacfc\ud559 \uc790\ubb38 \uc704\uc6d0\ud68c\uc758 \ubcf4\uc0c1 \uc758\uc7a5 \ub798\ub9ac<\/span> W. \uacfd(Larry W. Kwak<\/span><\/span><\/a>) M.D., Ph.D.\ub294 “\uc6b0\ub9ac\ub294 \uc0c1\uc5c5\uc6a9 CD19 CAR T\uc138\ud3ec \uce58\ub8cc\ub97c \ubc1b\uc740 \ud6c4 \uc7ac\ubc1c\ud558\ub294 \ub9bc\ud504\uc885 \ubc0f \ubc31\ud608\ubcd1 \ud658\uc790\uc758 \ub610 \ub2e4\ub978 \ud558\ub098\uc758 \uce58\ub8cc \uc635\uc158\uc73c\ub85c BAFFR-CAR T \uce58\ub8cc\ubc95\uc744 \uac1c\ubc1c\ud588\uc73c\uba70, \uc9c0\uae08\uae4c\uc9c0\uc758 \uacb0\uacfc\ub294 \ub3c5\uc131\uc744 \ucd5c\uc18c\ud654\ud558\ub294 \uc774\uc0c1\uc801\uc778 \ucd5c\ub300 \ud6a8\ub2a5\uc744 \ubcf4\uc778\ub2e4”\uace0 \ub9d0\ud588\ub2e4. \uacfd\uc740 \ud398\ud504\ub85c\ubbfc\uc758 \uc8fc\uc2dd \uc9c0\ubd84\uc744 \uac00\uc9c0\uace0 \uc788\ub2e4. \uadf8\ub294 “\uc6b0\ub9ac\ub294 \ud658\uc790 \uacb0\uacfc\ub97c \uc608\uce21\ud558\uace0 \ud6a8\uacfc\uc801\uc778 CAR T\uc138\ud3ec \uce58\ub8cc\ubc95\uc758 \uac1c\ubc1c\uc744 \uac00\uc18d\ud560 \uc218 \uc788\ub294 \ub2a5\ub825\uc744 \uac00\uc9c4 CAR T\uc138\ud3ec \uc81c\ud488\uc5d0 \ub300\ud55c \uac15\ub825\ud558\uace0 \uc2e0\ub8b0\ud560 \uc218 \uc788\ub294 \ub2e4\uae30\ub2a5 \ubd84\uc11d \uae30\ubc95\uc744 \uac1c\ubc1c\ud588\ub2e4”\uace0 \ub367\ubd99\uc600\ub2e4. <\/span><\/p>\n

\ubcf8 \uc784\uc0c1\uc2dc\ud5d8\uc758 \uc218\uc11d \uc870\uc0ac\uad00 \uacb8 \ud608\uc561\ud559 \ubc0f \uc870\ud608 \uc138\ud3ec \uc774\uc2dd \ub2f4\ub2f9 \ubd80\uad50\uc218\uc774\uc790 \uc2dc\ud2f0 \uc624\ube0c \ud638\ud504\uc758 \uba74\uc5ed \uc774\ud329\ud130 \uc138\ud3ec \uce58\ub8cc \ud504\ub85c\uadf8\ub7a8\uc758 \uc218\uc11d \uc758\ub8cc \ucc45\uc784\uc790\uc778 \uc5d8\ub9ac\uc790\ubca0\uc2a4 \ubc84\ub4dc<\/span>(Elizabeth Budde<\/span>) \ubc15\uc0ac\uac00 2023\ub144 12\uc6d4 \ubbf8\uad6d \ud608\uc561\ud559\ud68c \ucee8\ud37c\ub7f0\uc2a4\uc5d0\uc11c \ucd08\uae30 \uc784\uc0c1 \uc2dc\ud5d8 \uacb0\uacfc\ub97c \ubc1c\ud45c\ud588\ub2e4.<\/span><\/p>\n

\ubc84\ub4dc \ubc15\uc0ac\ub294<\/span> “\ube44\ud638\uc9c0\ud0a8 \ub9bc\ud504\uc885 \ud658\uc790 5\uba85\uacfc B\uc138\ud3ec \uae09\uc131 \ub9bc\ud504\uad6c\uc131 \ubc31\ud608\ubcd1 \ud658\uc790 1\uba85\uc774 PMB-CT01 \uce58\ub8cc\ub97c \ubc1b\uc558\ub294\ub370 \uadf8\ub4e4 100%\uac00 \uc9c0\uc18d\uc801\uc778 \ubc18\uc751\uc744 \ubcf4\uc600\ub2e4\ub294 \uac83\uc740 \ub180\ub77c\uc6b4 \uc77c”\uc774\ub77c\uba74\uc11c “CD19 CAR T \uce58\ub8cc \ud6c4 \uc7ac\ubc1c\ud55c \uc784\uc0c1 \uc2dc\ud5d8 \ud658\uc790\ub4e4 \uc911 \ub9ce\uc740 \uc218\uac00 CD19 \uc74c\uc131\uc774\uc5c8\ub2e4. PMB-CT01\uc740 \uc774 \ub51c\ub808\ub9c8\uc5d0 \uc9c1\uba74\ud55c \ub2e4\ub978 \ud658\uc790\ub4e4\uc5d0\uac8c\ub3c4 \uc2e4\ud589 \uac00\ub2a5\ud55c \uc635\uc158\uc744 \uc81c\uc2dc\ud560 \uc218 \uc788\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/span><\/p>\n

\ud398\ud504\ub85c\ubbfc \ubc14\uc774\uc624\uc758<\/span> COO \ud5e4\uc774\uc990 \uccad( Hazel Cheng<\/span>) \ubc15\uc0ac\ub294 “\uc774 \ubd84\uc11d \uae30\ubc95\uc740 PMB-CT01\uc758 \uac1c\ubc1c\uc744 \uac00\uc774\ub4dc\ud558\uae30 \uc704\ud574 \ud604\uc7ac \ubc0f \ubbf8\ub798\uc758 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0 \uc801\uc6a9\ub420 \uc218 \uc788\ub2e4”\uba74\uc11c “\ud398\ud2b8\ub85c\ubbfc\uc740 \uc7a0\uc7ac\uc801\uc73c\ub85c \uc720\ub9dd\ud55c \uc0c8\ub85c\uc6b4 \uc138\ud3ec \uce58\ub8cc\ubc95\uc758 \uc9c0\uc18d\uc801\uc778 \uacfc\ud559 \ubc0f \uc784\uc0c1\uc801 \uac1c\ubc1c\uc5d0 \uafb8\uc900\ud788 \uc804\ub150\ud558\uace0 \uc788\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/span><\/p>\n

PMB-CT01<\/span><\/p>\n

PMB-CT01\uc740 \ub3d9<\/span>\uc885<\/span> \ucd5c\ucd08\uc758<\/span> BAFFR \ud45c\uc801 \uc790\uac00 CAR T\uc138\ud3ec \uce58\ub8cc\ubc95\uc774\ub2e4.<\/span>\u00a0 <\/span>\uc885\uc591 \uad34\uc0ac \uc778\uc790<\/span> (TNF) \uc218\uc6a9\uccb4 \uc288\ud37c\ud328\ubc00<\/span>\ub9ac\uc758 \uc77c\uc6d0\uc778 <\/span>BAFF-R (B \uc138\ud3ec \ud65c\uc131 \uc778\uc790 \uc218\uc6a9\uccb4)\uc740 B \uc138\ud3ec\uc5d0\uc11c\ub9cc \uac70\uc758 \ub3c5\uc810\uc801\uc73c\ub85c \ubc1c\ud604\ub418\ub294 BAFF\uc758 \uc8fc\uc694 \uc218\uc6a9\uccb4\uc774\ub2e4.<\/span> BAFF-R \uc2e0\ud638 \uc804\ub2ec\uc740 \uc815\uc0c1\uc801\uc778 B \uc138\ud3ec \uc99d\uc2dd\uc744 \ucd09\uc9c4\ud558\uace0 B \uc138\ud3ec \uc0dd\uc874\uc5d0 \ud544\uc694\ud55c \uac83\uc73c\ub85c \ubcf4\uc774\uae30 \ub54c\ubb38\uc5d0 \uc885\uc591 \uc138\ud3ec\uac00 BAFF-R \ud56d\uc6d0\uc758 \uc190\uc2e4\uc744 \ud1b5\ud574 <\/span>\uce58\ub8cc\uc81c\ub97c<\/span> \ud53c\ud560 <\/span>\uac00\ub2a5\uc131\uc740 \uc801<\/span>\ub2e4<\/span>. \uc774\ub7ec\ud55c \ub3c5\ud2b9\ud55c \ud2b9\uc131\uc740 BAFFR-CAR T \uce58\ub8cc\ubc95\uc744 B \uc138\ud3ec \uc545\uc131 \uc885\uc591\uc758 <\/span>\uc544\uc8fc \uc720\ub9dd\ud55c <\/span>\uce58\ub8cc<\/span> \uc635\uc158<\/span>\uc73c\ub85c \ub9cc\ub4e0\ub2e4<\/span>.<\/span> BAFFR-CAR T\ub294 \ud56d-BAFFR <\/span>\ub2e8\uc77c \uc0ac\uc2ac \ub2e8\ud3b8 \uac00\ubcc0<\/span>(<\/span>scFv<\/span>) \ud56d\uccb4<\/span>\uc640 <\/span>2\uc138\ub300 \uc2e0\ud638 \ub3c4\uba54\uc778\uc778 <\/span>CD3 \u03b6\uc640 <\/span>4-1BB<\/span>\ub97c <\/span>\uc0ac\uc6a9\ud558\uc5ec \uad6c\uc131\ub418\uc5c8\ub2e4<\/span>.<\/span> \uc6b0\ub9ac\uc758 \uc5f0\uad6c\ub97c \ud1b5\ud574<\/span>\u00a0 BAFFR-CAR T\uc138\ud3ec\uac00 \ub3d9\ubb3c \ubaa8\ub378<\/span>\uacfc<\/span> \uc2dc\ud5d8\uad00 \ub0b4<\/span> \ub458 \ubaa8\ub450\uc5d0\uc11c <\/span>\uc778\uac04 \ub9bc\ud504\uc885\uacfc \ubc31\ud608\ubcd1\uc744 <\/span>\ud6a8\uacfc\uc801\uc73c\ub85c <\/span>\uc8fd<\/span>\uc778\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc785\uc99d\ud588\ub2e4<\/span>.<\/span> \ud398\ud504\ub85c\ubbfc\uc740 \uc2dc\ud2f0<\/span> \uc624\ube0c<\/span> \ud638\ud504\ub85c\ubd80\ud130<\/span> PMB-CT01<\/span>\uc758 <\/span>\uc9c0\uc801 \uc7ac\uc0b0\uad8c\uc744 \ub77c\uc774\uc120\uc2a4 \ubc1b\uc558\ub2e4<\/span>.<\/span>\u00a0<\/span><\/p>\n

\ud398\ud504\ub85c\ubbfc \ubc14\uc774\uc624<\/span><\/p>\n

\ud398\ud504\ub85c\ubbfc <\/span>\ubc14\uc774\uc624\ub294 <\/span>\uc554\uacfc \uba74\uc5ed\uc9c8\ud658\uc744 \uce58\ub8cc\ud558\uae30 \uc704\ud55c \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc744 \uac1c\ubc1c\ud558\ub294 \uce98\ub9ac\ud3ec\ub2c8\uc544 \uc5b4\ubc14\uc778\uc758 \uc784\uc0c1 \ub2e8\uacc4 \ubc14\uc774\uc624\ud14d \uae30\uc5c5\uc774\ub2e4<\/span>. \ud398\ud504\ub85c\ubbfc\uc758 \ub9ac\ub4dc \ud6c4\ubcf4\uc778 PMB-CT01(BAFFR-CAR T \uc138\ud3ec)\uc740 \ud604\uc7ac \uc7ac\ubc1c\uc131 \ubc0f \ub09c\uce58\uc131 B\uc138\ud3ec \uae09\uc131 \ub9bc\ud504\uad6c\uc131 \ubc31\ud608\ubcd1(B-ALL; NCT04690595)\uacfc B\uc138\ud3ec \ube44\ud638\uc9c0\ud0a8 \ub9bc\ud504\uc885(B-NHL; NCT05370430)\uc744 \uc784\uc0c1 1\uc0c1\uc5d0\uc11c \uce58\ub8cc\ud558\uae30 \uc704\ud574 \uc5f0\uad6c \uc911\uc774\ub2e4. \ud398\ud504\ub85c\ubbfc \ubc14\uc774\uc624\ub294 \ub610\ud55c BAFFR \uc774\uc911\ud2b9\uc774\uc131 T \uc138\ud3ec \uad00\uc5ec\uccb4\uc640 BAFFR-CAR NK \uc138\ud3ec\ub97c \uac1c\ubc1c\ud558\uace0 \uc788\ub2e4.<\/span><\/p>\n

\uc5f0\ub77d\ucc98<\/span>: John Fry,\u00a0john.fry@pepromenebio.com<\/span><\/a><\/span><\/p>\n

\ub85c\uace0<\/span> –\u00a0https:\/\/mma.prnasia.com\/media2\/1972356\/4847154\/Pepromene_Bio_Inc__Logo.jpg?p=medium600<\/span><\/a><\/span><\/p>\n

\u00a0<\/p>\n

<\/p>","protected":false},"author":1,"featured_media":22003,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[28,50],"tags":[],"class_list":["post-22002","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr","category-politics"],"blog_post_layout_featured_media_urls":{"thumbnail":"","full":""},"categories_names":{"28":{"name":"PR Newswire","link":"http:\/\/mhjn.dothome.co.kr\/en\/category\/pr%eb%89%b4%ec%8a%a4%ec%99%80%ec%9d%b4%ec%96%b4\/"},"50":{"name":"Politics\/Economy","link":"http:\/\/mhjn.dothome.co.kr\/en\/category\/politics\/"}},"tags_names":[],"comments_number":"0","wpmagazine_modules_lite_featured_media_urls":{"thumbnail":"","cvmm-medium":"","cvmm-medium-plus":"","cvmm-portrait":"","cvmm-medium-square":"","cvmm-large":"","cvmm-small":"","full":""},"_links":{"self":[{"href":"http:\/\/mhjn.dothome.co.kr\/en\/wp-json\/wp\/v2\/posts\/22002","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mhjn.dothome.co.kr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/mhjn.dothome.co.kr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/mhjn.dothome.co.kr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/mhjn.dothome.co.kr\/en\/wp-json\/wp\/v2\/comments?post=22002"}],"version-history":[{"count":0,"href":"http:\/\/mhjn.dothome.co.kr\/en\/wp-json\/wp\/v2\/posts\/22002\/revisions"}],"wp:attachment":[{"href":"http:\/\/mhjn.dothome.co.kr\/en\/wp-json\/wp\/v2\/media?parent=22002"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/mhjn.dothome.co.kr\/en\/wp-json\/wp\/v2\/categories?post=22002"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/mhjn.dothome.co.kr\/en\/wp-json\/wp\/v2\/tags?post=22002"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}