{"id":20424,"date":"2023-12-09T14:19:03","date_gmt":"2023-12-09T05:19:03","guid":{"rendered":"http:\/\/mhjn.dothome.co.kr\/menarini-group-%ec%83%88%eb%a1%9c%ec%9a%b4-%eb%ac%b4%ec%a7%84%ed%96%89-%ec%83%9d%ec%a1%b4-%eb%8d%b0%ec%9d%b4%ed%84%b0-%eb%b0%9c%ed%91%9c\/"},"modified":"2023-12-09T14:19:03","modified_gmt":"2023-12-09T05:19:03","slug":"menarini-group-%ec%83%88%eb%a1%9c%ec%9a%b4-%eb%ac%b4%ec%a7%84%ed%96%89-%ec%83%9d%ec%a1%b4-%eb%8d%b0%ec%9d%b4%ed%84%b0-%eb%b0%9c%ed%91%9c","status":"publish","type":"post","link":"http:\/\/mhjn.dothome.co.kr\/en\/menarini-group-%ec%83%88%eb%a1%9c%ec%9a%b4-%eb%ac%b4%ec%a7%84%ed%96%89-%ec%83%9d%ec%a1%b4-%eb%8d%b0%ec%9d%b4%ed%84%b0-%eb%b0%9c%ed%91%9c\/","title":{"rendered":"Menarini Group, \uc0c8\ub85c\uc6b4 \ubb34\uc9c4\ud589 \uc0dd\uc874 \ub370\uc774\ud130 \ubc1c\ud45c"},"content":{"rendered":"

— SABCS 2023\uc5d0\uc11c\u00a0ESR1 \ub3cc\uc5f0\ubcc0\uc774\uac00\u00a0\uc788\ub294\u00a0ER+, HER2- \uc804\uc774\uc131\u00a0\uc720\ubc29\uc554(mBC) \ud658\uc790\uc758\u00a0\uc784\uc0c1\uc801\uc73c\ub85c\u00a0\uad00\ub828\ub41c\u00a0\ud558\uc704\uad70\uc5d0\uc11c\u00a0\uc5bb\uc740\u00a0\uc624\ub974\uc138\ub974\ub450\u00ae(\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8) EMERALD \uc784\uc0c1\uc2dc\ud5d8\uc758\u00a0\uc0c8\ub85c\uc6b4\u00a0\ubb34\uc9c4\ud589\u00a0\uc0dd\uc874\u00a0\ub370\uc774\ud130\u00a0\ubc1c\ud45c<\/p>\n

– \uc81c3\uc0c1\u00a0EMERALD \uc784\uc0c1\uc2dc\ud5d8\uc758\u00a0\uc774\ubc88\u00a0\uc0c8\ub85c\uc6b4\u00a0\uc0ac\ud6c4\u00a0\ubd84\uc11d\uc740\u00a0\uc885\uc591\uc5d0\u00a0ESR1 \ub3cc\uc5f0\ubcc0\uc774\uac00\u00a0\uc788\ub294\u00a0\ub0b4\ubd84\ube44\u00a0\ubbfc\uac10\u00a0\uc9d1\ub2e8(CDK4\/6 \uc5b5\uc81c\uc81c\u00a0\uae30\uac04\uc774\u00a012\uac1c\uc6d4\u00a0\uc774\uc0c1)\uc5d0\uc11c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\ub97c\u00a0\ud3c9\uac00\ud558\uc600\ub2e4.<\/p>\n

– \uc774\u00a0\ubd84\uc11d\uc740\u00a0\uace8, \uac04\u00a0\ubc0f\/\ub610\ub294\u00a0\ud3d0\u00a0\uc804\uc774\u00a0\ud658\uc790, PIK3CA \ubc0f\u00a0TP53 \ub4f1\uc758\u00a0\ud754\ud55c\u00a0\ub3d9\ubc18\u00a0\ubcc0\uc774\u00a0\ud658\uc790, HER2 \ubc1c\ud604\uc774\u00a0\ub0ae\uc740\u00a0\ud658\uc790\u00a0\ub4f1\u00a0\uc2dc\ud5d8\ud55c\u00a0\ud558\uc704\uad70\u00a0\uc804\ubc18\uc5d0\uc11c\u00a0\ubb34\uc9c4\ud589\u00a0\uc0dd\uc874\uc758\u00a0\uc784\uc0c1\uc801\uc73c\ub85c\u00a0\uc720\uc758\ubbf8\ud55c\u00a0\uac1c\uc120\uc744\u00a0\ubcf4\uc600\ub2e4.<\/p>\n

– \uc774\ub7f0\u00a0\uacb0\uacfc\ub294\u00a0ESR1 \ubcc0\uc774\u00a0\uc885\uc591\uc774\u00a0\uc5ec\uc804\ud788\u00a0\ub0b4\ubd84\uc774\u00a0\ubbfc\uac10\uc131\uc778\u00a0\uacbd\uc6b0, ER \uacbd\ub85c\uac00\u00a0\uc8fc\uc694\u00a0\uc9c8\ubcd1\u00a0\ub3d9\uc778\uc77c\u00a0\uc218\u00a0\uc788\ub2e4\uace0\u00a0\uc785\uc99d\ud55c\ub2e4.<\/p>\n

\uc774\ud0c8\ub9ac\uc544\u00a0\ud53c\ub80c\uccb4\u00a0\ubc0f\u00a0\ub274\uc695<\/span>, 2023\ub144 12\uc6d4 9\uc77c<\/span> \/PRNewswire\/ —\u00a0\uc554 \ud658\uc790\uc5d0\uac8c \uc804\ud658\uc801 \uc554 \uce58\ub8cc\ubc95\uc744 \uc81c\uacf5\ud558\ub294 \ub370 \uc911\uc810\uc744 \ub450\ub294 \uc120\ub3c4\uc801\uc778 \uad6d\uc81c \uc81c\uc57d \ubc0f \uc9c4\ub2e8 \ud68c\uc0ac\uc778 Menarini Group(\uc774\ud558\u00a0\u00a0‘\uba54\ub098\ub9ac\ub2c8’)\uacfc Menarini Group\uc758 \uc644\uc804 \uc18c\uc720 \uc790\ud68c\uc0ac\uc778 Stemline Therapeutics, Inc.(\uc774\ud558 ‘Stemline’)\uac00 \uc624\ub298 \ubaa8\ub4e0 \uad00\ub828 \ud558\uc704\uad70\uc5d0\uc11c \ubb34\uc9c4\ud589 \uc0dd\uc874(PFS)\uc758 \uc784\uc0c1\uc801\uc73c\ub85c \uc720\uc758\ubbf8\ud55c \uac1c\uc120\uc744 \uc785\uc99d\ud55c \uc911\ucd94\uc801 EMERALD \uc784\uc0c1 \uc2dc\ud5d8\uc758 \uc0c8\ub85c\uc6b4 \uc0ac\ud6c4 \ubd84\uc11d \uacb0\uacfc\ub97c \uc81c\uc2dc\ud588\ub2e4. \uc774 \ub370\uc774\ud130\ub294 \ub0b4\ubd84\ube44 \ubbfc\uac10\uc131\uc774\uba70 ESR1 \ub3cc\uc5f0\ubcc0\uc774\uac00 \uc788\uace0 \uc774\uc804 CDK4\/6 \uc5b5\uc81c\uc81c \uce58\ub8cc \uae30\uac04\uc774 12\uac1c\uc6d4 \uc774\uc0c1\uc778 ER+, HER2- \uc9c4\ud589\uc131 \ub610\ub294 \uc804\uc774\uc131 \uc720\ubc29\uc554(mBC) \ud658\uc790\uc5d0\uc11c \ud45c\uc900\uce58\ub8cc(SOC)\uc640 \ube44\uad50\ud55c \ub2e8\uc77c \uc81c\uc81c \uc624\ub974\uc138\ub974\ub450(ORSERDU\u00ae, \uc131\ubd84\uba85: \uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8[elacestrant])\uc5d0\uc11c \ubc14\ub78c\uc9c1\ud55c PFS\ub97c \ubcf4\uc778\ub2e4. \uc774 \ub370\uc774\ud130\ub294 2023\ub144 12\uc6d4 5\uc77c\ubd80\ud130 9\uc77c\uae4c\uc9c0 \uc5f4\ub9ac\ub294 2023\ub144 San Antonio Breast Cancer Symposium(SABCS)\uc5d0\uc11c \ubc1c\ud45c\ub420 \uc608\uc815\uc774\ub2e4.<\/p>\n

EMERALD\ub294\u00a0\ub0b4\ubd84\ube44\u00a0\ub2e8\ub3c5\uc694\ubc95(\ud480\ubca0\uc2a4\ud2b8\ub780\ud2b8, \ub808\ud2b8\ub85c\uc878, \uc544\ub098\uc2a4\ud2b8\ub85c\uc878, \uc5d1\uc2a4\uba54\uc2a4\ud0c4) \ud45c\uc900\uce58\ub8cc\u00a0\ub300\ube44\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0\ud1b5\uacc4\uc801\uc73c\ub85c\u00a0\uc720\uc758\ud55c\u00a0PFS\ub97c\u00a0\uc785\uc99d\ud55c\u00a0\uc81c3\uc0c1\u00a0\ub4f1\ub85d\u00a0\uc784\uc0c1\uc2dc\ud5d8\uc774\ub2e4. \uc774\ub7f0\u00a0\uacb0\uacfc\uc5d0\u00a0\uae30\ucd08\ud558\uc5ec\u00a0FDA\ub294\u00a02023\ub144\u00a01\uc6d4\u00a027\uc77c\u00a0\ud558\ub098\u00a0\uc774\uc0c1\uc758\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\u00a0\ud6c4\u00a0\uc9c8\ubcd1\u00a0\uc9c4\ud589\uc744\u00a0\ubcf4\uc778\u00a0ER+, HER2-,\u00a0ESR1\u00a0\ub3cc\uc5f0\ubcc0\uc774\u00a0\uc9c4\ud589\uc131\u00a0\ub610\ub294\u00a0\uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\uc774\u00a0\uc788\ub294\u00a0\ud3d0\uacbd\u00a0\ud6c4\u00a0\uc5ec\uc131\uc774\ub098\u00a0\uc131\uc778\u00a0\ub0a8\uc131\uc758\u00a0\uce58\ub8cc\uc5d0\u00a0\uc624\ub974\uc138\ub974\ub450\ub97c\u00a0\uc2b9\uc778\ud558\uc600\ub2e4.\u00a0ESR1\u00a0\ub3cc\uc5f0\ubcc0\uc774\ub294\u00a040% of ER+, HER2- \uc9c4\ud589\uc131\u00a0\ub610\ub294\u00a0mBC\uc758\u00a0\ucd5c\ub300\u00a040%\uc5d0\u00a0\uc874\uc7ac\ud55c\ub2e4. \uc774\ub294\u00a0\ud45c\uc900\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\uc5d0\u00a0\ub300\ud55c\u00a0\ub0b4\uc131\uc744\u00a0\uc77c\uc73c\ud0a8\ub2e4\uace0\u00a0\uc54c\ub824\uc838\u00a0\uc788\ub294\u00a0\ud55c\u00a0\uc694\uc778\uc774\uba70\u00a0\ud604\uc7ac\uae4c\uc9c0\u00a0\uc774\ub7f0\u00a0\ub3cc\uc5f0\ubcc0\uc774\uac00\u00a0\uc788\ub294\u00a0\uc885\uc591\uc740\u00a0\uce58\ub8cc\ud558\uae30\u00a0\uc5b4\ub824\uc6e0\ub2e4.\u00a0<\/p>\n

\uc911\uc694\ud55c\u00a0\uc810\uc73c\ub85c\u00a0SABCS 2022\uc5d0\uc11c\u00a0\ubc1c\ud45c\ub418\uc5c8\ub358\u00a0EMERALD PFS \uacb0\uacfc\uc758\u00a0\uc774\uc804\u00a0\uc0ac\ud6c4\u00a0\ud558\uc704\uad70\u00a0\ubd84\uc11d\uc740\u00a0\uc774\uc804\u00a0CDK4\/6 \uc5b5\uc81c\uc81c\u00a0\uce58\ub8cc\u00a0\uae30\uac04\uc774\u00a0\uc624\ub974\uc138\ub974\ub450\uc5d0\uc11c\u00a0\uae34\u00a0PFS\uacfc\u00a0\uad00\ub828\ub418\uc5c8\uc9c0\ub9cc\u00a0SOC\uc5d0\uc11c\ub294\u00a0\uadf8\ub807\uc9c0\u00a0\uc54a\uc558\ub2e4\uace0\u00a0\uc785\uc99d\ud558\uc600\ub2e4. EMERALD \ubb34\uc791\uc704\ubc30\uc815\u00a0\uc804\u00a012\uac1c\uc6d4\u00a0\uc774\uc0c1\u00a0CDK4\/6 \uc5b5\uc81c\uc81c\ub97c\u00a0\ud22c\uc5ec\u00a0\ubc1b\uc740\u00a0ESR1 \ub3cc\uc5f0\ubcc0\uc774\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0PFS \uc911\uc559\uac12\uc740\u00a08.6\uac1c\uc6d4\uc774\uace0\u00a0SOC\uc5d0\uc11c\ub294\u00a01.9\uac1c\uc6d4\ub85c\u00a0\uc624\ub974\uc138\ub974\ub450\uc5d0\uc11c\u00a0\uc9c4\ud589\u00a0\ub610\ub294\u00a0\uc0ac\ub9dd\u00a0\uc704\ud5d8\uc774\u00a059% \uac10\uc18c\ud558\uc600\ub2e4(HR=0.41 95% CI: 0.26-0.63).\u00a0[1]<\/p>\n

\uc774\u00a0\uc5c5\ub370\uc774\ud2b8\ub41c\u00a0\ubd84\uc11d\uc5d0\uc11c\u00a0Menarini Stemline\uc740\u00a0\uace8, \uac04\u00a0\ubc0f\/\ub610\ub294\u00a0\ud3d0\uc804\uc774\uac00\u00a0\uc788\ub294\u00a0\ud658\uc790, \ud754\ud55c\u00a0PIK3CA \ub610\ub294\u00a0TP53 \ubcc0\uc774\ub97c\u00a0\ub3d9\ubc18\ud55c\u00a0\ud658\uc790\u00a0\ub610\ub294\u00a0HER2 \ubc1c\ud604\uc774\u00a0\ub0ae\uc740\u00a0\ud658\uc790\u00a0\ub4f1\uc744\u00a0\ud3ec\ud568\ud574\u00a0\ub9ce\uc774\u00a0\ub098\ud0c0\ub098\ub294\u00a0\uc784\uc0c1\u00a0\ubc0f\u00a0\uc8fc\uc694\u00a0\uc0dd\uccb4\ud45c\uc9c0\uc790\u00a0\ud558\uc704\uad70\uc5d0\uc11c\u00a0\ub2e8\uc77c\u00a0\uc81c\uc81c\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0\uc720\uc775\uc131\uc744\u00a0\ud3c9\uac00\ud558\uc600\ub2e4.<\/p>\n

\ubbf8\uad6d\u00a0\ud14d\uc0ac\uc2a4\u00a0\ub300\ud559\u00a0\uc0cc\uc548\ud1a0\ub2c8\uc624\u00a0MD Anderson Cancer Center \uc720\ubc29\uc554\u00a0\uc804\ubb38\uc758\uc774\uc790\u00a0\ub0b4\uacfc\u00a0\uad50\uc218\uc778\u00a0Virginia Kaklamani \uc758\ud559\ubc15\uc0ac\ub294\u00a0“\uc774\u00a0\uc5c5\ub370\uc774\ud2b8\ub41c\u00a0\uad00\ucc30\uacb0\uacfc\ub294\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ub2e8\ub3c5\uc694\ubc95\uc774\u00a0ESR1\u00a0\ub3cc\uc5f0\ubcc0\uc774\uac00\u00a0\uc788\ub294\u00a0ER+, HER2- \uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\u00a0\ud658\uc790\uc758\u00a0\uc720\ub9dd\ud55c\u00a0\uc774\ucc28\uce58\ub8cc\u00a0\ubc29\ubc95”\uc774\ub77c\uba70, ” CDK 4\/6\uc744\u00a0\uc774\uc6a9\ud55c\u00a0\uc774\uc804\u00a0\uce58\ub8cc\uae30\uac04\uc774\u00a012\uac1c\uc6d4\u00a0\uc774\uc0c1\uc778\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\u00a0\ub2e8\ub3c5\uc694\ubc95\uc774\u00a0\ub9ce\uc740\u00a0\uc911\uc694\u00a0\ud558\uc704\uad70\u00a0\uc804\ubc18\uc5d0\uc11c\u00a0\ud45c\uc900\uce58\ub8cc\u00a0\ub300\ube44\u00a0\ubb34\uc9c4\ud589\u00a0\uc0dd\uc874\uc758\u00a0\uc77c\uad00\uc801\uc778\u00a0\uac1c\uc120\uc744\u00a0\ubcf4\uc600\uace0, \uc774\ub7f0\u00a0\uacb0\uacfc\ub294\u00a0\uace8\uc804\uc774\ubfd0\ub9cc\u00a0\uc544\ub2c8\ub77c\u00a0\uac04\u00a0\ubc0f\/\ub610\ub294\u00a0\ud3d0\u00a0\uc804\uc774\uc5d0\uc11c\ub3c4\u00a0\uad00\ucc30\ub418\uc5c8\uace0, PIK3CA \ubc0f\u00a0TP53 \ub4f1\uc758\u00a0\ud754\ud55c\u00a0\ub3d9\ubc18\u00a0\ubcc0\uc774\u00a0\ud658\uc790\uc640\u00a0HER2 \ubc1c\ud604\uc774\u00a0\ub0ae\uc740\u00a0\ud658\uc790\uc5d0\uc11c\ub3c4\u00a0\uad00\ucc30\ub418\uc5c8\ub2e4”\uace0\u00a0\ub9d0\ud588\ub2e4.<\/p>\n

\uc624\ub974\uc138\ub974\ub450\ub294\u00a0\uc774\ub7f0\u00a0\ud558\uc704\uad70\u00a0\uc804\ubc18\uc5d0\uc11c\u00a0\ub0b4\ubd84\ube44\u00a0\ub2e8\ub3c5\uc694\ubc95(\ud480\ubca0\uc2a4\ud2b8\ub780\ud2b8, \ub808\ud2b8\ub85c\uc878, \uc544\ub098\uc2a4\ud2b8\ub85c\uc878, \uc5d1\uc2a4\uba54\uc2a4\ud0c4) \ud45c\uc900\uce58\ub8cc\uc5d0\u00a0\ube44\ud574\u00a0\uc784\uc0c1\uc801\uc73c\ub85c\u00a0\uc720\uc758\ubbf8\ud55c\u00a0PFS \uac1c\uc120\uc744\u00a0\ubcf4\uc600\ub2e4. \uc624\ub974\uc138\ub974\ub450\ub294\u00a0\uc774\uc804\u00a0CDK4\/6 \uc5b5\uc81c\uc81c\u00a0\uce58\ub8cc\u00a0\uae30\uac04\uc774\u00a012\uac1c\uc6d4\u00a0\uc774\uc0c1\uc77c\u00a0\ub54c\u00a0PFS\uc758\u00a0\uc720\uc758\ud55c\u00a0\uc99d\uac00\ub97c\u00a0\ubcf4\uc5ec\u00a0ESR1\u00a0\ub3cc\uc5f0\ubcc0\uc774\u00a0\uc885\uc591\uc774\u00a0\uc5ec\uc804\ud788\u00a0\ub0b4\ubd84\ube44\u00a0\ubbfc\uac10\uc131\uc778\u00a0\uacbd\uc6b0, \uc804\uc774\u00a0\ubd80\uc704, \ub3d9\ubc18\u00a0PIK3CA \ub610\ub294\u00a0TP53 \ubcc0\uc774\u00a0\ub610\ub294\u00a0\ub0ae\uc740\u00a0HER2 \ubc1c\ud604\uacfc\u00a0\ubb34\uad00\ud558\uac8c\u00a0ER \uacbd\ub85c\uac00\u00a0\uc8fc\uc694\u00a0\uc9c8\ubcd1\u00a0\ub3d9\uc778\uc77c\u00a0\uc218\u00a0\uc788\ub2e4\uace0\u00a0\uc81c\uc2dc\ud558\uc600\ub2e4.\u00a0\uc804\uccb4\u00a0\ucd08\ub85d\uc740\u00a0\uc5ec\uae30<\/a>[http:\/\/sabcs2023.eventscribe.net\/fsPopup.asp?Mode=posterinfo&PosterID=623727<\/a> ]\uc5d0\uc11c\u00a0\ubcfc\u00a0\uc218\u00a0\uc788\ub2e4.<\/p>\n

Menarini Group\uc758\u00a0Elcin Barker Ergun \ucd5c\uace0\uacbd\uc601\uc790(CEO)\ub294\u00a0“SABCS 2023\uc5d0\uc11c\u00a0\ubc1c\ud45c\ub418\ub294\u00a0\ub370\uc774\ud130\ub294\u00a0\uc624\ub974\uc138\ub974\ub450\uc640\u00a0ESR1 \ub3cc\uc5f0\ubcc0\uc774\u00a0\uc885\uc591\uc744\u00a0\ud45c\uc801\ud558\ub294\u00a0\ub2e8\uc77c\u00a0\uc81c\uc81c\ub85c\uc11c\u00a0\uadf8\u00a0\uc7a0\uc7ac\uc131\uc5d0\u00a0\ub300\ud55c\u00a0\ubcf8\uc0ac\uc758\u00a0\uc9c0\uc2dd\uc744\u00a0\uae30\ucd08\ub85c\u00a0\ud55c\ub2e4”\uba70\u00a0“Menarini Stemline\uc758\u00a0\ubaa9\ud45c\ub294\u00a0\uc554\u00a0\ud658\uc790\uc758\u00a0\uc0dd\uba85\uc744\u00a0\uc5f0\uc7a5\ud558\uace0\u00a0\uc0b6\uc744\u00a0\uac1c\uc120\ud558\ub294\u00a0\uc804\ud658\uc801\u00a0\uce58\ub8cc\ubc95\uc744\u00a0\uc81c\uacf5\ud558\ub294\u00a0\uac83\uc73c\ub85c, \ub9ce\uc740\u00a0\uc801\uc808\ud55c\u00a0\uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\u00a0\ud658\uc790\uc5d0\uac8c\u00a0\ub9ce\uc774\u00a0\ud544\uc694\ud55c\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\uacfc\u00a0\uc548\uc804\uc131\u00a0\ud504\ub85c\ud30c\uc77c\uc774\u00a0\uad00\ub9ac\uac00\ub2a5\ud55c\u00a0\uc694\ubc95\uc744\u00a0\uc81c\uacf5\ud558\uac8c\u00a0\ub418\uc5ec\u00a0\uae30\uc058\ub2e4”\uace0\u00a0\ub9d0\ud588\ub2e4.<\/p>\n

\uc548\uc804\uc131\u00a0\ub370\uc774\ud130\ub294\u00a0\uc774\uc804\uc5d0\u00a0\ubcf4\uace0\ub41c\u00a0\uacb0\uacfc\uc640\u00a0\uc77c\uce58\ud558\uc600\ub2e4. \uc624\ub974\uc138\ub974\ub450\uc5d0\uc11c\u00a0\uac00\uc7a5\u00a0\ud754\ud55c\u00a0\uc774\uc0c1\ubc18\uc751\uc740\u00a0\uadfc\uace8\uaca9\ud1b5, \uba54\uc2a4\uaebc\uc6c0, \uc911\uc131\uc9c0\ubc29\u00a0\uc99d\uac00, \ucf5c\ub808\uc2a4\ud14c\ub864\u00a0\uc0c1\uc2b9, \uad6c\ud1a0, \ud53c\ub85c, \uc18c\ud654\ubd88\ub7c9, \uc124\uc0ac, \uce7c\uc298\u00a0\uac10\uc18c, \uc694\ud1b5, \ud06c\ub808\uc544\ud2f0\ub2cc\u00a0\uc99d\uac00, \uad00\uc808\ud1b5, \ub098\ud2b8\ub968\u00a0\uac10\uc18c, \ubcc0\ube44, \ub450\ud1b5, \uc5bc\uad74\u00a0\ud64d\uc870, \ubcf5\ud1b5, \ube48\ud608, \uce7c\ub968\u00a0\uac10\uc18c, \uc54c\ub77c\ub2cc\u00a0\uc544\ubbf8\ub178\uc804\uc774\ud6a8\uc18c\u00a0\uc99d\uac00\u00a0\ub4f1\uc774\ub2e4. \uc624\ub974\uc138\ub974\ub450\uc5d0\u00a0\ub300\ud55c\u00a0\uc911\uc694\ud55c\u00a0\uc548\uc804\uc131\u00a0\uc815\ubcf4\uac00\u00a0\uc544\ub798\u00a0\uc81c\uacf5\ub41c\ub2e4.<\/p>\n

SABCS 2023\uc5d0\uc11c\u00a0\ubc1c\ud45c\ub418\ub294\u00a0Menarini Group\/ Stemline Therapeutics\uc758\u00a0\uc804\uccb4\u00a0\ubc1c\ud45c\uc5d0\u00a0\ub300\ud55c\u00a0\uc0c1\uc138\u00a0\uc815\ubcf4\ub294\u00a0\uc5ec\uae30<\/a>[https:\/\/www.menarini.com\/en-us\/news\/news-detail\/menarini-group-announces-new-data-on-orserdu174-elacestrant-at-the-2023-san-antonio-breast-cancer-symposium-and-on-elzonris174-tagraxofusp-erzs-at-the-65th-american-society-of-hematology<\/a> ]\ub97c\u00a0\ucc38\uc870\ud55c\ub2e4.<\/p>\n

EMERALD \uc81c3\uc0c1\u00a0\uc2dc\ud5d8(NCT03778931) \uc18c\uac1c<\/p>\n

EMERALD \uc81c3\uc0c1\u00a0\uc784\uc0c1\uc2dc\ud5d8\uc740\u00a0ER+, HER2-\uc9c4\ud589\uc131\/mBC \ud658\uc790\uc5d0\uc11c\u00a0\uc774\ucc28\u00a0\ub610\ub294\u00a0\uc0bc\ucc28\u00a0\ub2e8\ub3c5\uc694\ubc95\uc73c\ub85c\uc11c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\ub97c\u00a0\ud3c9\uac00\ud558\ub294\u00a0\ubb34\uc791\uc704\ubc30\uc815, \uacf5\uac1c, \ud65c\uc131\u00a0\ub300\uc870\u00a0\uc2dc\ud5d8\uc774\ub2e4. \uc774\u00a0\uc2dc\ud5d8\uc740\u00a0CDK4\/6 \uc5b5\uc81c\uc81c\ub97c\u00a0\ud3ec\ud568\ud558\uc5ec\u00a0\ud558\ub098\u00a0\ub610\ub294\u00a0\ub450\u00a0\uac00\uc9c0\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\uc73c\ub85c\u00a0\uc774\uc804\u00a0\uc694\ubc95\uc744\u00a0\ubc1b\uc740\u00a0478\uba85\uc744\u00a0\ub4f1\ub85d\ud558\uc600\ub2e4. \uc774\u00a0\uc2dc\ud5d8\uc758\u00a0\ud658\uc790\ub4e4\uc740\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\ub098\u00a0\uc2dc\ud5d8\uc790\uac00\u00a0\uc120\ud0dd\ud55c\u00a0\uc2b9\uc778\ub41c\u00a0\ud638\ub974\ubaac\u00a0\uc81c\uc81c\u00a0\uc911\u00a0\ud558\ub098\uc5d0\u00a0\ubb34\uc791\uc704\ubc30\uc815\ub418\uc5c8\ub2e4. \uc774\u00a0\uc2dc\ud5d8\uc758\u00a0\uc77c\ucc28\u00a0\ud3c9\uac00\ubcc0\uc218\ub294\u00a0\uc804\uccb4\u00a0\ud658\uc790\u00a0\uc9d1\ub2e8\uacfc\u00a0\uc5d0\uc2a4\ud2b8\ub85c\uac90\u00a0\uc218\uc6a9\uccb4\u00a01 \uc720\uc804\uc790(ESR1) \ubcc0\uc774\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\ubb34\uc9c4\ud589\u00a0\uc0dd\uc874(PFS)\uc774\uc5c8\ub2e4. ESR1-\ubcc0\uc774\uac00\u00a0\uc788\ub294\u00a0\uc885\uc591\u00a0\ud658\uc790\uad70\uc5d0\uc11c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\uc758\u00a0PFS \uc911\uc559\uac12\uc740\u00a03.8\uac1c\uc6d4\uc774\uc5c8\uace0, SOC\uc5d0\uc11c\ub294\u00a01.9\uac1c\uc6d4\ub85c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\ub294\u00a0SOC \ub300\ube44\u00a0\uc9c4\ud589\u00a0\ub610\ub294\u00a0\uc0ac\ub9dd\u00a0\uc704\ud5d8\uc744\u00a045% \ub0ae\ucd94\uc5c8\ub2e4\u00a0\uac10\uc18c\ud558\uc600\ub2e4(PFS HR=0.55, 95% CI: 0.39, 0.77).<\/p>\n

\uc624\ub974\uc138\ub974\ub450(\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8) \uc18c\uac1c\u00a0\ubbf8\uad6d\u00a0\uc801\uc751\uc99d:\u00a0\uc624\ub974\uc138\ub974\ub450(\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8) 345mg \uc815\uc81c\ub294\u00a0\ud558\ub098\u00a0\uc774\uc0c1\uc758\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\u00a0\ud6c4\u00a0\uc9c8\ubcd1\u00a0\uc9c4\ud589\uc744\u00a0\ubcf4\uc778\u00a0\uc5d0\uc2a4\ud2b8\ub85c\uac90\u00a0\uc218\uc6a9\uccb4(ER) \uc591\uc131, \uc778\uac04\u00a0\uc0c1\ud53c\u00a0\uc131\uc7a5\uc778\uc790\u00a0\uc218\uc6a9\uccb4\u00a02(HER2) \uc74c\uc131, ESR1 \ub3cc\uc5f0\ubcc0\uc774\u00a0\uc9c4\ud589\uc131\u00a0\ub610\ub294\u00a0\uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\uc774\u00a0\uc788\ub294\u00a0\ud3d0\uacbd\u00a0\ud6c4\u00a0\uc5ec\uc131\u00a0\ub610\ub294\u00a0\uc131\uc778\u00a0\ub0a8\uc131\uc758\u00a0\uce58\ub8cc\uc5d0\u00a0\uc801\uc751\ub41c\ub2e4.<\/p>\n

\ubbf8\uad6d\uc758\u00a0\uc804\uccb4\u00a0\ucc98\ubc29\u00a0\uc815\ubcf4\ub294\u00a0www.orserdu.com<\/a>\uc5d0\uc11c\u00a0\ucc3e\uc544\ubcfc\u00a0\uc218\u00a0\uc788\ub2e4.<\/p>\n

\uc911\uc694\ud55c\u00a0\uc548\uc804\uc131\u00a0\uc815\ubcf4
\uacbd\uace0\u00a0\ubc0f\u00a0\uc8fc\uc758\uc0ac\ud56d<\/p>\n

\uc774\uc0c1\uc9c0\uc9c8\ud608\uc99d:\u00a0\uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d\uacfc\u00a0\uace0\uc911\uc131\uc9c0\ubc29\ud608\uc99d\uc740\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\uac01\uac01\u00a030% \ubc0f\u00a027% \ubc1c\uc0dd\ub960\ub85c\u00a0\ubc1c\uc0dd\ud588\ub2e4. 3\ub4f1\uae09\u00a0\ubc0f\u00a04\ub4f1\uae09\u00a0\uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d\u00a0\ubc0f\u00a0\uace0\uc911\uc131\uc9c0\ubc29\ud608\uc99d\uc758\u00a0\ubc1c\uc0dd\ub960\uc740\u00a0\uac01\uac01\u00a00.9% \ubc0f\u00a02.2%\uc600\ub2e4. \uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\uc2dc\uc791\u00a0\uc804\uacfc\u00a0\ud22c\uc5ec\u00a0\uc911\u00a0\uc815\uae30\uc801\uc73c\ub85c\u00a0\uc9c0\uc9c8\u00a0\ud504\ub85c\ud30c\uc77c\uc744\u00a0\ubaa8\ub2c8\ud130\ub9c1\ud55c\ub2e4.<\/p>\n

\ubc30\ud0dc\uc544\u00a0\ub3c5\uc131: \ub3d9\ubb3c\u00a0\uad00\ucc30\uacb0\uacfc\uc640\u00a0\uadf8\u00a0\uc791\uc6a9\uae30\uc804\uc5d0\u00a0\uae30\ucd08\ud558\uc5ec\u00a0\uc624\ub974\uc138\ub974\ub450\ub294\u00a0\uc784\uc2e0\ubd80\uc5d0\u00a0\ud22c\uc5ec\u00a0\uc2dc\u00a0\ud0dc\uc544\u00a0\uc190\uc0c1\uc744\u00a0\uc57c\uae30\ud560\u00a0\uc218\u00a0\uc788\ub2e4. \uc784\uc2e0\ubd80\uc640\u00a0\uac00\uc784\u00a0\uc5ec\uc131\uc5d0\uac8c\u00a0\ud0dc\uc544\uc5d0\u00a0\ub300\ud55c\u00a0\uc7a0\uc7ac\uc801\u00a0\uc704\ud5d8\uc744\u00a0\uc548\ub0b4\ud55c\ub2e4. \uac00\uc784\u00a0\uc5ec\uc131\uc740\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\uc911\uacfc\u00a0\ub9c8\uc9c0\ub9c9\u00a0\ud22c\uc5ec\u00a0\ud6c4\u00a01\uc8fc\u00a0\ub3d9\uc548\u00a0\ud6a8\uacfc\uc801\uc778\u00a0\ud53c\uc784\ubc95\uc744\u00a0\uc0ac\uc6a9\ud574\uc57c\u00a0\ud55c\ub2e4. \uac00\uc784\u00a0\uc5ec\uc131\u00a0\ud30c\ud2b8\ub108\uac00\u00a0\uc788\ub294\u00a0\ub0a8\uc131\u00a0\ud658\uc790\ub294\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\uc911\uacfc\u00a0\ub9c8\uc9c0\ub9c9\u00a0\ud22c\uc5ec\u00a0\ud6c4\u00a01\uc8fc\u00a0\ub3d9\uc548\u00a0\ud6a8\uacfc\uc801\uc778\u00a0\ud53c\uc784\ubc95\uc744\u00a0\uc0ac\uc6a9\ud574\uc57c\u00a0\ud55c\ub2e4.<\/p>\n

\uc774\uc0c1\ubc18\uc751<\/p>\n

\uc911\ub300\ud55c\u00a0\uc774\uc0c1\ubc18\uc751\uc740\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\ud658\uc790\uc758\u00a012%\uc5d0\uc11c\u00a0\ubc1c\uc0dd\ud558\uc600\ub2e4. \uc624\ub974\uc138\ub974\ub450\ub97c\u00a0\ud22c\uc5ec\ud55c\u00a0\ud658\uc790\uc758\u00a0>1%\uc5d0\uc11c\u00a0\ubc1c\uc0dd\ud55c\u00a0\uc911\ub300\ud55c\u00a0\uc774\uc0c1\ubc18\uc751\uc740\u00a0\uadfc\uace8\uaca9\ud1b5(1.7%) \ubc0f\u00a0\uba54\uc2a4\uaebc\uc6c0(1.3%)\uc774\uc5c8\ub2e4. \uce58\uba85\uc801\u00a0\uc774\uc0c1\ubc18\uc751\uc740\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\ud658\uc790\uc758\u00a01.7%\uc5d0\uc11c\u00a0\ubc1c\uc0dd\ud558\uc600\uc73c\uba70\u00a0\uc2ec\uc815\uc9c0, \ud328\ud608\uc131\u00a0\uc1fc\ud06c, \uac8c\uc2e4\uc5fc, \ubd88\uba85\uc758\u00a0\uc6d0\uc778(\uac01\u00a01\uba85) \ub4f1\uc774\uc5c8\ub2e4.
\uc2e4\ud5d8\uc2e4\u00a0\ube44\uc815\uc0c1\uc744\u00a0\ud3ec\ud568\ud574\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0\uac00\uc7a5\u00a0\ud754\ud55c\u00a0\uc774\uc0c1\ubc18\uc751(>10%)\uc740\u00a0\uadfc\uace8\uaca9\ud1b5(41%), \uba54\uc2a4\uaebc\uc6c0(35%), \ucf5c\ub808\uc2a4\ud14c\ub864\u00a0\uc99d\uac00(30%), AST \uc99d\uac00(29%), \uc911\uc131\uc9c0\ubc29\u00a0\uc99d\uac00(27%), \ud53c\ub85c(26%), \ud5e4\ubaa8\uae00\ub85c\ube48\u00a0\uac10\uc18c(26%), \uad6c\ud1a0(19%), ALT \uc99d\uac00(17%), \ub098\ud2b8\ub968\u00a0\uac10\uc18c(16%), \ud06c\ub808\uc544\ud2f0\ub2cc\u00a0\uc99d\uac00(16%), \uc2dd\uc695\u00a0\uac10\uc18c(15%), \uc124\uc0ac(13%), \ub450\ud1b5(12%), \ubcc0\ube44(12%), \ubcf5\ud1b5(11%), \uc5bc\uad74\u00a0\ud64d\uc870(11%), \uc18c\ud654\ubd88\ub7c9(10%) \ub4f1\uc774\uc5c8\ub2e4.<\/p>\n

\uc57d\ubb3c\u00a0\uc0c1\ud638\uc791\uc6a9<\/p>\n

CYP3A4 \uc720\ub3c4\uc81c\u00a0\ubc0f\/\ub610\ub294\u00a0\uc5b5\uc81c\uc81c\u00a0\ubcd1\uc6a9:\u00a0 \uac15\ub825\u00a0\ub0b4\uc9c0\u00a0\uc911\ub4f1\ub3c4\u00a0CYP3A4 \uc5b5\uc81c\uc81c\uc640\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0\ubcd1\uc6a9\uc744\u00a0\ud53c\ud55c\ub2e4. \uac15\ub825\u00a0\ub0b4\uc9c0\u00a0\uc911\ub4f1\ub3c4\u00a0CYP3A4 \uc720\ub3c4\uc81c\uc640\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0\ubcd1\uc6a9\uc744\u00a0\ud53c\ud55c\ub2e4.<\/p>\n

\ud2b9\uc218\u00a0\uc9d1\ub2e8\uc5d0\uc11c\uc758\u00a0\uc0ac\uc6a9<\/p>\n

\uc218\uc720: \uc218\uc720\ubd80\ub294\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\uc911\uacfc\u00a0\ub9c8\uc9c0\ub9c9\u00a0\ud22c\uc5ec\u00a0\ud6c4\u00a01\uc8fc\u00a0\ub3d9\uc548\u00a0\uc218\uc720\ud558\uc9c0\u00a0\uc54a\ub3c4\ub85d\u00a0\uc548\ub0b4\ud55c\ub2e4.<\/p>\n

\uac04\uc7a5\uc560: \uc911\uc99d\u00a0\uac04\uc7a5\uc560(Child-Pugh C) \ud658\uc790\uc5d0\uc11c\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\uc0ac\uc6a9\uc744\u00a0\ud53c\ud55c\ub2e4. \uc911\ub4f1\ub3c4\u00a0\uac04\uc7a5\uc560(Child-Pugh B) \ud658\uc790\uc5d0\uc11c\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\uc6a9\ub7c9\uc744\u00a0\ub0ae\ucd98\ub2e4.
\uc18c\uc544\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0\uc548\uc804\uc131\u00a0\ubc0f\u00a0\ud6a8\uacfc\ub294\u00a0\uc218\ub9bd\ub418\uc9c0\u00a0\uc54a\uc558\ub2e4.<\/p>\n

\uc758\uc2ec\ub418\ub294\u00a0\uc774\uc0c1\ubc18\uc751\uc744\u00a0\ubcf4\uace0\ud558\ub824\uba74\u00a0Stemline Therapeutics, Inc.\uc5d0\u00a01-877-332-7961 \ub610\ub294\u00a0FDA\uc5d0\u00a01-800-FDA-1088\u00a0\ub610\ub294\u00a0www.fda.gov\/medwatch<\/a>\ub85c\u00a0\uc5f0\ub77d\ud55c\ub2e4.<\/p>\n

\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\u00a0\uc784\uc0c1\u00a0\uac1c\ubc1c\u00a0\ud504\ub85c\uadf8\ub7a8\u00a0\uc18c\uac1c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\ub294\u00a0\uc77c\ubd80\u00a0\uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c\u00a0\uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\u00a0\uc9c8\ud658\uc5d0\u00a0\ub300\ud574\u00a0\ub2e8\ub3c5\uc694\ubc95\uc73c\ub85c\ub098\u00a0\ub2e4\ub978\u00a0\uc694\ubc95\uacfc\uc758\u00a0\ubcd1\uc6a9\uc694\ubc95\uc73c\ub85c\u00a0\uc5f0\uad6c\u00a0\uc911\uc774\ub2e4. ELEVATE(NCT05563220<\/a>[https:\/\/clinicaltrials.gov\/study\/NCT05563220<\/a> ])\ub294\u00a0\uc54c\ud3a0\ub9ac\uc2ed, \uc5d0\ubca0\ub864\ub9ac\ubb34\uc2a4, \ud314\ubcf4\uc2dc\ud074\ub9bd, \uc544\ubca0\ub9c8\uc2dc\ud074\ub9bd, \ub9ac\ubcf4\uc2dc\ud074\ub9bd\uacfc\u00a0\ubcd1\uc6a9\ud55c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\uc758\u00a0\uc548\uc804\uc131\u00a0\ubc0f\u00a0\uc720\ud6a8\uc131\uc744\u00a0\ud3c9\uac00\ud558\ub294\u00a0\uc81c1b\/2\uc0c1\u00a0\uc784\uc0c1\uc2dc\ud5d8\uc774\ub2e4. ELECTRA(NCT05386108<\/a>[https:\/\/clinicaltrials.gov\/study\/NCT05386108<\/a> ])\ub294\u00a0ER+, HER2- \uc720\ubc29\uc554\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\uc544\ubca0\ub9c8\uc2dc\ud074\ub9bd\uacfc\u00a0\ubcd1\uc6a9\ud55c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\ub97c\u00a0\ud3c9\uac00\ud558\ub294\u00a0\uacf5\uac1c, \uc81c1b\/2\uc0c1, \ub2e4\uae30\uad00\u00a0\uc2dc\ud5d8\uc774\ub2e4. \uc774\u00a0\uc81c2\uc0c1\u00a0\ubd80\ubd84\uc740\u00a0\uc774\u00a0\uc911\u00a0\ub1cc\uc804\uc774\uac00\u00a0\uc788\ub294\u00a0\ud658\uc790\u00a0\uc9d1\ub2e8\uc5d0\uc11c\u00a0\uc774\u00a0\ud22c\uc5ec\u00a0\uc694\ubc95\uc744\u00a0\ud3c9\uac00\ud55c\ub2e4. ELCIN(NCT05596409<\/a>[https:\/\/clinicaltrials.gov\/study\/NCT05596409<\/a> ])\uc740\u00a0\ud558\ub098\u00a0\ub610\ub294\u00a0\ub450\u00a0\uac00\uc9c0\u00a0\uc774\uc804\u00a0\ud638\ub974\ubaac\u00a0\uc694\ubc95\uc744\u00a0\ubc1b\uc558\uc73c\uba70\u00a0\uc804\uc774\u00a0\uc0c1\ud0dc\uc5d0\uc11c\u00a0\uc0ac\uc774\ud074\ub9b0\u00a0\uc758\uc874\uc131\u00a0\ud0a4\ub098\uc544\uc81c\u00a0\ud45c\uc801\u00a0\ud6a8\uc18c\u00a0CDK4 \ubc0f\u00a0CDK6 \uc5b5\uc81c\uc81c(CDK4\/6i)\ub97c\u00a0\ud22c\uc5ec\u00a0\ubc1b\uc740\u00a0\uc801\uc774\u00a0\uc5c6\ub294\u00a0\uc5d0\uc2a4\ud2b8\ub85c\uac90\u00a0\uc218\uc6a9\uccb4\u00a0\uc591\uc131(ER+)\/\uc778\uac04\u00a0\uc0c1\ud53c\uc131\uc7a5\u00a0\uc778\uc790\u00a0\uc218\uc6a9\uccb42 \uc74c\uc131(HER2-) \uc9c4\ud589\uc131\/\uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\uc758\u00a0\uc720\ud6a8\uc131\uc744\u00a0\ud3c9\uac00\ud558\ub294\u00a0\uc81c2\uc0c1\u00a0\uc784\uc0c1\uc2dc\ud5d8\uc774\ub2e4.<\/p>\n

Menarini Group \uc18c\uac1c<\/p>\n

Menarini Group\uc740\u00a044\uc5b5\u00a0\ub2ec\ub7ec\u00a0\uc774\uc0c1\uc758\u00a0\ub9e4\ucd9c\uacfc\u00a017000\uba85\uc774\u00a0\ub118\ub294\u00a0\uc9c1\uc6d0\uc744\u00a0\ub454\u00a0\uc120\ub3c4\uc801\uc778\u00a0\uad6d\uc81c\u00a0\uc81c\uc57d\u00a0\ubc0f\u00a0\uc9c4\ub2e8\u00a0\ud68c\uc0ac\uc774\ub2e4. Menarini\ub294\u00a0\uc2ec\uc7a5\ud559, \uc885\uc591\ud559, \ud638\ud761\uae30\ud559, \uc18c\ud654\uae30\ud559, \uac10\uc5fc\u00a0\uc9c8\ud658, \ub2f9\ub1e8\ubcd1, \uc5fc\uc99d\u00a0\ubc0f\u00a0\uc9c4\ud1b5\u00a0\uc758\uc57d\ud488\uc73c\ub85c\u00a0\ubd80\ud569\ub418\uc9c0\u00a0\uc54a\ub294\u00a0\ud544\uc694\uac00\u00a0\ub192\uc740\u00a0\uce58\ub8cc\u00a0\uc601\uc5ed\uc5d0\u00a0\uc911\uc810\uc744\u00a0\ub454\ub2e4. 18\uac1c\u00a0\uc81c\uc870\uc18c\uc640\u00a08\uac1c\u00a0\uc5f0\uad6c\uac1c\ubc1c\u00a0\uc13c\ud130\uac00\u00a0\uc788\ub294\u00a0Menarini Group\uc758\u00a0\uc758\uc57d\ud488\uc740\u00a0\uc804\u00a0\uc138\uacc4\u00a0140\uac1c\uad6d\uc5d0\u00a0\uc81c\uacf5\ub41c\ub2e4. \ucd94\uac00\u00a0\uc815\ubcf4\ub294\u00a0www.menarini.com<\/a>\uc744\u00a0\ubc29\ubb38\ud55c\ub2e4.<\/p>\n

Stemline Therapeutics Inc. \uc18c\uac1c
Stemline Therapeutics Inc.(\uc774\ud558\u00a0‘Stemline’)\uc740\u00a0Menarini Group\uc758\u00a0\uc644\uc804\u00a0\uc18c\uc720\u00a0\uc790\ud68c\uc0ac\ub85c\u00a0\uc0c8\ub85c\uc6b4\u00a0\uc554\uce58\ub8cc\uc81c\uc758\u00a0\uac1c\ubc1c\u00a0\ubc0f\u00a0\uc0c1\uc6a9\ud654\uc5d0\u00a0\uc911\uc810\uc744\u00a0\ub454\u00a0\uc0c1\uc6a9\u00a0\ub2e8\uacc4\u00a0\uc0dd\ubb3c\uc758\uc57d\ud488\u00a0\ud68c\uc0ac\uc774\ub2e4. Stemline\uc740\u00a0\ubbf8\uad6d\uacfc\u00a0\uc720\ub7fd\u00a0\uc5f0\ud569\uc5d0\uc11c\u00a0\ud558\ub098\u00a0\uc774\uc0c1\uc758\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\u00a0\ud6c4\u00a0\uc9c8\ubcd1\u00a0\uc9c4\ud589\uc744\u00a0\ubcf4\uc778\u00a0\uc5d0\uc2a4\ud2b8\ub85c\uac90\u00a0\uc218\uc6a9\uccb4(ER) \uc591\uc131, \uc778\uac04\u00a0\uc0c1\ud53c\uc131\uc7a5\uc778\uc790\u00a0\uc218\uc6a9\uccb4\u00a01(HER2) \uc74c\uc131, ESR1 \ub3cc\uc5f0\ubcc0\uc774\u00a0\uc9c4\ud589\uc131\u00a0\ub610\ub294\u00a0\uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\uc774\u00a0\uc788\ub294\u00a0\ud3d0\uacbd\u00a0\ud6c4\u00a0\uc5ec\uc131\u00a0\ub610\ub294\u00a0\uc131\uc778\u00a0\ub0a8\uc131\uc758\u00a0\uce58\ub8cc\uc5d0\u00a0\uc801\uc751\ub418\ub294\u00a0\uacbd\uad6c\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\uc778\u00a0\uc624\ub974\uc138\ub974\ub450\u00ae(\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8)\ub97c\u00a0\uc2dc\ud310\ud558\uace0\u00a0\uc788\ub2e4. Stemline\uc740\u00a0\uacf5\uaca9\uc801\u00a0\ud608\uc561\uc554\uc778\u00a0\ubaa8\uad6c\u00a0\ud615\uc9c8\uc138\ud3ec\uc591\u00a0\uc218\uc9c0\uc138\ud3ec\u00a0\uc885\uc591(BPDCN) \ud658\uc790\uc5d0\uc11c\u00a0CD123\uc744\u00a0\ud45c\uc801\ud558\ub294\u00a0\uc0c8\ub85c\uc6b4\u00a0\ud45c\uc801\u00a0\uce58\ub8cc\uc81c\uc778\u00a0\uc5d8\uc874\ub9ac\uc2a4(ELZONRIS\u00ae, \uc131\ubd84\uba85: \ud0c0\uadf8\ub77d\uc18c\ud478\ub974\ud504[tagraxofusp-erzs])\ub3c4\u00a0\ubbf8\uad6d\uacfc\u00a0\uc720\ub7fd\uc5d0\uc11c\u00a0\ud310\ub9e4\ud558\uace0\u00a0\uc788\ub2e4. \uc774\ub294\u00a0\ud604\uc7ac\uae4c\uc9c0\u00a0\ubbf8\uad6d\uacfc\u00a0\uc720\ub7fd\uc5f0\ud569\uc5d0\uc11cBPDCN\uc5d0\u00a0\ub300\ud574\u00a0\uc2b9\uc778\ub41c\u00a0\uc720\uc77c\ud55c\u00a0\uce58\ub8cc\uc81c\uc774\ub2e4. Stemline\uc740\u00a0\ub2e4\ubc1c\uc131\u00a0\uace8\uc218\uc885\uc5d0\u00a0\ub300\ud55c\u00a0XPO1 \uc5b5\uc81c\uc81c\uc778\u00a0\ub125\uc2a4\ud3ec\ube44\uc624(NEXPOVIO\u00ae, \uc131\ubd84\uba85: \uc140\ub9ac\ub125\uc18c[Selinexor])\ub3c4\u00a0\uc720\ub7fd\uc5d0\uc11c\u00a0\ud310\ub9e4\ud558\uace0\u00a0\uc788\ub2e4. Stemline\uc740\u00a0\uc5ec\ub7ec\u00a0\uace0\ud615\uc554\u00a0\ubc0f\u00a0\ud608\uc561\uc554\uc5d0\u00a0\ub300\ud574\u00a0\uc5ec\ub7ec\u00a0\ub2e8\uacc4\ub85c\u00a0\uac1c\ubc1c\ub418\uace0\u00a0\uc788\ub294\u00a0\uad11\ubc94\uc704\ud55c\u00a0\uc18c\ubd84\uc790\u00a0\ubc0f\u00a0\uc0dd\ubb3c\ud559\uc801\u00a0\uc758\uc57d\ud488\u00a0\uc784\uc0c1\u00a0\ud30c\uc774\ud504\ub77c\uc778\ub3c4\u00a0\ubcf4\uc720\ud558\uace0\u00a0\uc788\ub2e4.<\/p>\n

[1]\u00a0Bardia et al. EMERALD phase 3 trial of elacestrant versus standard of care endocrine therapy in patients with ER+\/HER2- metastatic breast cancer: Updated results by duration of prior CDK4\/6i in metastatic setting. SABCS 2022. GS3-01<\/p>\n

\ub85c\uace0\u00a0–\u00a0https:\/\/mma.prnasia.com\/media2\/2296569\/Menarini_Industrie_Farmaceutiche_Riunite_Logo.jpg?p=medium600<\/a><\/p>","protected":false},"excerpt":{"rendered":"

<\/p>\n

— SABCS 2023\uc5d0\uc11c\u00a0ESR1 \ub3cc\uc5f0\ubcc0\uc774\uac00\u00a0\uc788\ub294\u00a0ER+, HER2- \uc804\uc774\uc131\u00a0\uc720\ubc29\uc554(mBC) \ud658\uc790\uc758\u00a0\uc784\uc0c1\uc801\uc73c\ub85c\u00a0\uad00\ub828\ub41c\u00a0\ud558\uc704\uad70\uc5d0\uc11c\u00a0\uc5bb\uc740\u00a0\uc624\ub974\uc138\ub974\ub450\u00ae(\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8) EMERALD \uc784\uc0c1\uc2dc\ud5d8\uc758\u00a0\uc0c8\ub85c\uc6b4\u00a0\ubb34\uc9c4\ud589\u00a0\uc0dd\uc874\u00a0\ub370\uc774\ud130\u00a0\ubc1c\ud45c<\/p>\n

– \uc81c3\uc0c1\u00a0EMERALD \uc784\uc0c1\uc2dc\ud5d8\uc758\u00a0\uc774\ubc88\u00a0\uc0c8\ub85c\uc6b4\u00a0\uc0ac\ud6c4\u00a0\ubd84\uc11d\uc740\u00a0\uc885\uc591\uc5d0\u00a0ESR1 \ub3cc\uc5f0\ubcc0\uc774\uac00\u00a0\uc788\ub294\u00a0\ub0b4\ubd84\ube44\u00a0\ubbfc\uac10\u00a0\uc9d1\ub2e8(CDK4\/6 \uc5b5\uc81c\uc81c\u00a0\uae30\uac04\uc774\u00a012\uac1c\uc6d4\u00a0\uc774\uc0c1)\uc5d0\uc11c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\ub97c\u00a0\ud3c9\uac00\ud558\uc600\ub2e4.<\/p>\n

– \uc774\u00a0\ubd84\uc11d\uc740\u00a0\uace8, \uac04\u00a0\ubc0f\/\ub610\ub294\u00a0\ud3d0\u00a0\uc804\uc774\u00a0\ud658\uc790, PIK3CA \ubc0f\u00a0TP53 \ub4f1\uc758\u00a0\ud754\ud55c\u00a0\ub3d9\ubc18\u00a0\ubcc0\uc774\u00a0\ud658\uc790, HER2 \ubc1c\ud604\uc774\u00a0\ub0ae\uc740\u00a0\ud658\uc790\u00a0\ub4f1\u00a0\uc2dc\ud5d8\ud55c\u00a0\ud558\uc704\uad70\u00a0\uc804\ubc18\uc5d0\uc11c\u00a0\ubb34\uc9c4\ud589\u00a0\uc0dd\uc874\uc758\u00a0\uc784\uc0c1\uc801\uc73c\ub85c\u00a0\uc720\uc758\ubbf8\ud55c\u00a0\uac1c\uc120\uc744\u00a0\ubcf4\uc600\ub2e4.<\/p>\n

– \uc774\ub7f0\u00a0\uacb0\uacfc\ub294\u00a0ESR1 \ubcc0\uc774\u00a0\uc885\uc591\uc774\u00a0\uc5ec\uc804\ud788\u00a0\ub0b4\ubd84\uc774\u00a0\ubbfc\uac10\uc131\uc778\u00a0\uacbd\uc6b0, ER \uacbd\ub85c\uac00\u00a0\uc8fc\uc694\u00a0\uc9c8\ubcd1\u00a0\ub3d9\uc778\uc77c\u00a0\uc218\u00a0\uc788\ub2e4\uace0\u00a0\uc785\uc99d\ud55c\ub2e4.<\/p>\n

\uc774\ud0c8\ub9ac\uc544\u00a0\ud53c\ub80c\uccb4\u00a0\ubc0f\u00a0\ub274\uc695<\/span>, 2023\ub144 12\uc6d4 9\uc77c<\/span> \/PRNewswire\/ —\u00a0\uc554 \ud658\uc790\uc5d0\uac8c \uc804\ud658\uc801 \uc554 \uce58\ub8cc\ubc95\uc744 \uc81c\uacf5\ud558\ub294 \ub370 \uc911\uc810\uc744 \ub450\ub294 \uc120\ub3c4\uc801\uc778 \uad6d\uc81c \uc81c\uc57d \ubc0f \uc9c4\ub2e8 \ud68c\uc0ac\uc778 Menarini Group(\uc774\ud558\u00a0\u00a0‘\uba54\ub098\ub9ac\ub2c8’)\uacfc Menarini Group\uc758 \uc644\uc804 \uc18c\uc720 \uc790\ud68c\uc0ac\uc778 Stemline Therapeutics, Inc.(\uc774\ud558 ‘Stemline’)\uac00 \uc624\ub298 \ubaa8\ub4e0 \uad00\ub828 \ud558\uc704\uad70\uc5d0\uc11c \ubb34\uc9c4\ud589 \uc0dd\uc874(PFS)\uc758 \uc784\uc0c1\uc801\uc73c\ub85c \uc720\uc758\ubbf8\ud55c \uac1c\uc120\uc744 \uc785\uc99d\ud55c \uc911\ucd94\uc801 EMERALD \uc784\uc0c1 \uc2dc\ud5d8\uc758 \uc0c8\ub85c\uc6b4 \uc0ac\ud6c4 \ubd84\uc11d \uacb0\uacfc\ub97c \uc81c\uc2dc\ud588\ub2e4. \uc774 \ub370\uc774\ud130\ub294 \ub0b4\ubd84\ube44 \ubbfc\uac10\uc131\uc774\uba70 ESR1 \ub3cc\uc5f0\ubcc0\uc774\uac00 \uc788\uace0 \uc774\uc804 CDK4\/6 \uc5b5\uc81c\uc81c \uce58\ub8cc \uae30\uac04\uc774 12\uac1c\uc6d4 \uc774\uc0c1\uc778 ER+, HER2- \uc9c4\ud589\uc131 \ub610\ub294 \uc804\uc774\uc131 \uc720\ubc29\uc554(mBC) \ud658\uc790\uc5d0\uc11c \ud45c\uc900\uce58\ub8cc(SOC)\uc640 \ube44\uad50\ud55c \ub2e8\uc77c \uc81c\uc81c \uc624\ub974\uc138\ub974\ub450(ORSERDU\u00ae, \uc131\ubd84\uba85: \uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8[elacestrant])\uc5d0\uc11c \ubc14\ub78c\uc9c1\ud55c PFS\ub97c \ubcf4\uc778\ub2e4. \uc774 \ub370\uc774\ud130\ub294 2023\ub144 12\uc6d4 5\uc77c\ubd80\ud130 9\uc77c\uae4c\uc9c0 \uc5f4\ub9ac\ub294 2023\ub144 San Antonio Breast Cancer Symposium(SABCS)\uc5d0\uc11c \ubc1c\ud45c\ub420 \uc608\uc815\uc774\ub2e4.<\/p>\n

EMERALD\ub294\u00a0\ub0b4\ubd84\ube44\u00a0\ub2e8\ub3c5\uc694\ubc95(\ud480\ubca0\uc2a4\ud2b8\ub780\ud2b8, \ub808\ud2b8\ub85c\uc878, \uc544\ub098\uc2a4\ud2b8\ub85c\uc878, \uc5d1\uc2a4\uba54\uc2a4\ud0c4) \ud45c\uc900\uce58\ub8cc\u00a0\ub300\ube44\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0\ud1b5\uacc4\uc801\uc73c\ub85c\u00a0\uc720\uc758\ud55c\u00a0PFS\ub97c\u00a0\uc785\uc99d\ud55c\u00a0\uc81c3\uc0c1\u00a0\ub4f1\ub85d\u00a0\uc784\uc0c1\uc2dc\ud5d8\uc774\ub2e4. \uc774\ub7f0\u00a0\uacb0\uacfc\uc5d0\u00a0\uae30\ucd08\ud558\uc5ec\u00a0FDA\ub294\u00a02023\ub144\u00a01\uc6d4\u00a027\uc77c\u00a0\ud558\ub098\u00a0\uc774\uc0c1\uc758\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\u00a0\ud6c4\u00a0\uc9c8\ubcd1\u00a0\uc9c4\ud589\uc744\u00a0\ubcf4\uc778\u00a0ER+, HER2-,\u00a0ESR1\u00a0\ub3cc\uc5f0\ubcc0\uc774\u00a0\uc9c4\ud589\uc131\u00a0\ub610\ub294\u00a0\uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\uc774\u00a0\uc788\ub294\u00a0\ud3d0\uacbd\u00a0\ud6c4\u00a0\uc5ec\uc131\uc774\ub098\u00a0\uc131\uc778\u00a0\ub0a8\uc131\uc758\u00a0\uce58\ub8cc\uc5d0\u00a0\uc624\ub974\uc138\ub974\ub450\ub97c\u00a0\uc2b9\uc778\ud558\uc600\ub2e4.\u00a0ESR1\u00a0\ub3cc\uc5f0\ubcc0\uc774\ub294\u00a040% of ER+, HER2- \uc9c4\ud589\uc131\u00a0\ub610\ub294\u00a0mBC\uc758\u00a0\ucd5c\ub300\u00a040%\uc5d0\u00a0\uc874\uc7ac\ud55c\ub2e4. \uc774\ub294\u00a0\ud45c\uc900\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\uc5d0\u00a0\ub300\ud55c\u00a0\ub0b4\uc131\uc744\u00a0\uc77c\uc73c\ud0a8\ub2e4\uace0\u00a0\uc54c\ub824\uc838\u00a0\uc788\ub294\u00a0\ud55c\u00a0\uc694\uc778\uc774\uba70\u00a0\ud604\uc7ac\uae4c\uc9c0\u00a0\uc774\ub7f0\u00a0\ub3cc\uc5f0\ubcc0\uc774\uac00\u00a0\uc788\ub294\u00a0\uc885\uc591\uc740\u00a0\uce58\ub8cc\ud558\uae30\u00a0\uc5b4\ub824\uc6e0\ub2e4.\u00a0<\/p>\n

\uc911\uc694\ud55c\u00a0\uc810\uc73c\ub85c\u00a0SABCS 2022\uc5d0\uc11c\u00a0\ubc1c\ud45c\ub418\uc5c8\ub358\u00a0EMERALD PFS \uacb0\uacfc\uc758\u00a0\uc774\uc804\u00a0\uc0ac\ud6c4\u00a0\ud558\uc704\uad70\u00a0\ubd84\uc11d\uc740\u00a0\uc774\uc804\u00a0CDK4\/6 \uc5b5\uc81c\uc81c\u00a0\uce58\ub8cc\u00a0\uae30\uac04\uc774\u00a0\uc624\ub974\uc138\ub974\ub450\uc5d0\uc11c\u00a0\uae34\u00a0PFS\uacfc\u00a0\uad00\ub828\ub418\uc5c8\uc9c0\ub9cc\u00a0SOC\uc5d0\uc11c\ub294\u00a0\uadf8\ub807\uc9c0\u00a0\uc54a\uc558\ub2e4\uace0\u00a0\uc785\uc99d\ud558\uc600\ub2e4. EMERALD \ubb34\uc791\uc704\ubc30\uc815\u00a0\uc804\u00a012\uac1c\uc6d4\u00a0\uc774\uc0c1\u00a0CDK4\/6 \uc5b5\uc81c\uc81c\ub97c\u00a0\ud22c\uc5ec\u00a0\ubc1b\uc740\u00a0ESR1 \ub3cc\uc5f0\ubcc0\uc774\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0PFS \uc911\uc559\uac12\uc740\u00a08.6\uac1c\uc6d4\uc774\uace0\u00a0SOC\uc5d0\uc11c\ub294\u00a01.9\uac1c\uc6d4\ub85c\u00a0\uc624\ub974\uc138\ub974\ub450\uc5d0\uc11c\u00a0\uc9c4\ud589\u00a0\ub610\ub294\u00a0\uc0ac\ub9dd\u00a0\uc704\ud5d8\uc774\u00a059% \uac10\uc18c\ud558\uc600\ub2e4(HR=0.41 95% CI: 0.26-0.63).\u00a0[1]<\/p>\n

\uc774\u00a0\uc5c5\ub370\uc774\ud2b8\ub41c\u00a0\ubd84\uc11d\uc5d0\uc11c\u00a0Menarini Stemline\uc740\u00a0\uace8, \uac04\u00a0\ubc0f\/\ub610\ub294\u00a0\ud3d0\uc804\uc774\uac00\u00a0\uc788\ub294\u00a0\ud658\uc790, \ud754\ud55c\u00a0PIK3CA \ub610\ub294\u00a0TP53 \ubcc0\uc774\ub97c\u00a0\ub3d9\ubc18\ud55c\u00a0\ud658\uc790\u00a0\ub610\ub294\u00a0HER2 \ubc1c\ud604\uc774\u00a0\ub0ae\uc740\u00a0\ud658\uc790\u00a0\ub4f1\uc744\u00a0\ud3ec\ud568\ud574\u00a0\ub9ce\uc774\u00a0\ub098\ud0c0\ub098\ub294\u00a0\uc784\uc0c1\u00a0\ubc0f\u00a0\uc8fc\uc694\u00a0\uc0dd\uccb4\ud45c\uc9c0\uc790\u00a0\ud558\uc704\uad70\uc5d0\uc11c\u00a0\ub2e8\uc77c\u00a0\uc81c\uc81c\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0\uc720\uc775\uc131\uc744\u00a0\ud3c9\uac00\ud558\uc600\ub2e4.<\/p>\n

\ubbf8\uad6d\u00a0\ud14d\uc0ac\uc2a4\u00a0\ub300\ud559\u00a0\uc0cc\uc548\ud1a0\ub2c8\uc624\u00a0MD Anderson Cancer Center \uc720\ubc29\uc554\u00a0\uc804\ubb38\uc758\uc774\uc790\u00a0\ub0b4\uacfc\u00a0\uad50\uc218\uc778\u00a0Virginia Kaklamani \uc758\ud559\ubc15\uc0ac\ub294\u00a0“\uc774\u00a0\uc5c5\ub370\uc774\ud2b8\ub41c\u00a0\uad00\ucc30\uacb0\uacfc\ub294\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ub2e8\ub3c5\uc694\ubc95\uc774\u00a0ESR1\u00a0\ub3cc\uc5f0\ubcc0\uc774\uac00\u00a0\uc788\ub294\u00a0ER+, HER2- \uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\u00a0\ud658\uc790\uc758\u00a0\uc720\ub9dd\ud55c\u00a0\uc774\ucc28\uce58\ub8cc\u00a0\ubc29\ubc95”\uc774\ub77c\uba70, ” CDK 4\/6\uc744\u00a0\uc774\uc6a9\ud55c\u00a0\uc774\uc804\u00a0\uce58\ub8cc\uae30\uac04\uc774\u00a012\uac1c\uc6d4\u00a0\uc774\uc0c1\uc778\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\u00a0\ub2e8\ub3c5\uc694\ubc95\uc774\u00a0\ub9ce\uc740\u00a0\uc911\uc694\u00a0\ud558\uc704\uad70\u00a0\uc804\ubc18\uc5d0\uc11c\u00a0\ud45c\uc900\uce58\ub8cc\u00a0\ub300\ube44\u00a0\ubb34\uc9c4\ud589\u00a0\uc0dd\uc874\uc758\u00a0\uc77c\uad00\uc801\uc778\u00a0\uac1c\uc120\uc744\u00a0\ubcf4\uc600\uace0, \uc774\ub7f0\u00a0\uacb0\uacfc\ub294\u00a0\uace8\uc804\uc774\ubfd0\ub9cc\u00a0\uc544\ub2c8\ub77c\u00a0\uac04\u00a0\ubc0f\/\ub610\ub294\u00a0\ud3d0\u00a0\uc804\uc774\uc5d0\uc11c\ub3c4\u00a0\uad00\ucc30\ub418\uc5c8\uace0, PIK3CA \ubc0f\u00a0TP53 \ub4f1\uc758\u00a0\ud754\ud55c\u00a0\ub3d9\ubc18\u00a0\ubcc0\uc774\u00a0\ud658\uc790\uc640\u00a0HER2 \ubc1c\ud604\uc774\u00a0\ub0ae\uc740\u00a0\ud658\uc790\uc5d0\uc11c\ub3c4\u00a0\uad00\ucc30\ub418\uc5c8\ub2e4”\uace0\u00a0\ub9d0\ud588\ub2e4.<\/p>\n

\uc624\ub974\uc138\ub974\ub450\ub294\u00a0\uc774\ub7f0\u00a0\ud558\uc704\uad70\u00a0\uc804\ubc18\uc5d0\uc11c\u00a0\ub0b4\ubd84\ube44\u00a0\ub2e8\ub3c5\uc694\ubc95(\ud480\ubca0\uc2a4\ud2b8\ub780\ud2b8, \ub808\ud2b8\ub85c\uc878, \uc544\ub098\uc2a4\ud2b8\ub85c\uc878, \uc5d1\uc2a4\uba54\uc2a4\ud0c4) \ud45c\uc900\uce58\ub8cc\uc5d0\u00a0\ube44\ud574\u00a0\uc784\uc0c1\uc801\uc73c\ub85c\u00a0\uc720\uc758\ubbf8\ud55c\u00a0PFS \uac1c\uc120\uc744\u00a0\ubcf4\uc600\ub2e4. \uc624\ub974\uc138\ub974\ub450\ub294\u00a0\uc774\uc804\u00a0CDK4\/6 \uc5b5\uc81c\uc81c\u00a0\uce58\ub8cc\u00a0\uae30\uac04\uc774\u00a012\uac1c\uc6d4\u00a0\uc774\uc0c1\uc77c\u00a0\ub54c\u00a0PFS\uc758\u00a0\uc720\uc758\ud55c\u00a0\uc99d\uac00\ub97c\u00a0\ubcf4\uc5ec\u00a0ESR1\u00a0\ub3cc\uc5f0\ubcc0\uc774\u00a0\uc885\uc591\uc774\u00a0\uc5ec\uc804\ud788\u00a0\ub0b4\ubd84\ube44\u00a0\ubbfc\uac10\uc131\uc778\u00a0\uacbd\uc6b0, \uc804\uc774\u00a0\ubd80\uc704, \ub3d9\ubc18\u00a0PIK3CA \ub610\ub294\u00a0TP53 \ubcc0\uc774\u00a0\ub610\ub294\u00a0\ub0ae\uc740\u00a0HER2 \ubc1c\ud604\uacfc\u00a0\ubb34\uad00\ud558\uac8c\u00a0ER \uacbd\ub85c\uac00\u00a0\uc8fc\uc694\u00a0\uc9c8\ubcd1\u00a0\ub3d9\uc778\uc77c\u00a0\uc218\u00a0\uc788\ub2e4\uace0\u00a0\uc81c\uc2dc\ud558\uc600\ub2e4.\u00a0\uc804\uccb4\u00a0\ucd08\ub85d\uc740\u00a0\uc5ec\uae30<\/a>[http:\/\/sabcs2023.eventscribe.net\/fsPopup.asp?Mode=posterinfo&PosterID=623727<\/a> ]\uc5d0\uc11c\u00a0\ubcfc\u00a0\uc218\u00a0\uc788\ub2e4.<\/p>\n

Menarini Group\uc758\u00a0Elcin Barker Ergun \ucd5c\uace0\uacbd\uc601\uc790(CEO)\ub294\u00a0“SABCS 2023\uc5d0\uc11c\u00a0\ubc1c\ud45c\ub418\ub294\u00a0\ub370\uc774\ud130\ub294\u00a0\uc624\ub974\uc138\ub974\ub450\uc640\u00a0ESR1 \ub3cc\uc5f0\ubcc0\uc774\u00a0\uc885\uc591\uc744\u00a0\ud45c\uc801\ud558\ub294\u00a0\ub2e8\uc77c\u00a0\uc81c\uc81c\ub85c\uc11c\u00a0\uadf8\u00a0\uc7a0\uc7ac\uc131\uc5d0\u00a0\ub300\ud55c\u00a0\ubcf8\uc0ac\uc758\u00a0\uc9c0\uc2dd\uc744\u00a0\uae30\ucd08\ub85c\u00a0\ud55c\ub2e4”\uba70\u00a0“Menarini Stemline\uc758\u00a0\ubaa9\ud45c\ub294\u00a0\uc554\u00a0\ud658\uc790\uc758\u00a0\uc0dd\uba85\uc744\u00a0\uc5f0\uc7a5\ud558\uace0\u00a0\uc0b6\uc744\u00a0\uac1c\uc120\ud558\ub294\u00a0\uc804\ud658\uc801\u00a0\uce58\ub8cc\ubc95\uc744\u00a0\uc81c\uacf5\ud558\ub294\u00a0\uac83\uc73c\ub85c, \ub9ce\uc740\u00a0\uc801\uc808\ud55c\u00a0\uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\u00a0\ud658\uc790\uc5d0\uac8c\u00a0\ub9ce\uc774\u00a0\ud544\uc694\ud55c\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\uacfc\u00a0\uc548\uc804\uc131\u00a0\ud504\ub85c\ud30c\uc77c\uc774\u00a0\uad00\ub9ac\uac00\ub2a5\ud55c\u00a0\uc694\ubc95\uc744\u00a0\uc81c\uacf5\ud558\uac8c\u00a0\ub418\uc5ec\u00a0\uae30\uc058\ub2e4”\uace0\u00a0\ub9d0\ud588\ub2e4.<\/p>\n

\uc548\uc804\uc131\u00a0\ub370\uc774\ud130\ub294\u00a0\uc774\uc804\uc5d0\u00a0\ubcf4\uace0\ub41c\u00a0\uacb0\uacfc\uc640\u00a0\uc77c\uce58\ud558\uc600\ub2e4. \uc624\ub974\uc138\ub974\ub450\uc5d0\uc11c\u00a0\uac00\uc7a5\u00a0\ud754\ud55c\u00a0\uc774\uc0c1\ubc18\uc751\uc740\u00a0\uadfc\uace8\uaca9\ud1b5, \uba54\uc2a4\uaebc\uc6c0, \uc911\uc131\uc9c0\ubc29\u00a0\uc99d\uac00, \ucf5c\ub808\uc2a4\ud14c\ub864\u00a0\uc0c1\uc2b9, \uad6c\ud1a0, \ud53c\ub85c, \uc18c\ud654\ubd88\ub7c9, \uc124\uc0ac, \uce7c\uc298\u00a0\uac10\uc18c, \uc694\ud1b5, \ud06c\ub808\uc544\ud2f0\ub2cc\u00a0\uc99d\uac00, \uad00\uc808\ud1b5, \ub098\ud2b8\ub968\u00a0\uac10\uc18c, \ubcc0\ube44, \ub450\ud1b5, \uc5bc\uad74\u00a0\ud64d\uc870, \ubcf5\ud1b5, \ube48\ud608, \uce7c\ub968\u00a0\uac10\uc18c, \uc54c\ub77c\ub2cc\u00a0\uc544\ubbf8\ub178\uc804\uc774\ud6a8\uc18c\u00a0\uc99d\uac00\u00a0\ub4f1\uc774\ub2e4. \uc624\ub974\uc138\ub974\ub450\uc5d0\u00a0\ub300\ud55c\u00a0\uc911\uc694\ud55c\u00a0\uc548\uc804\uc131\u00a0\uc815\ubcf4\uac00\u00a0\uc544\ub798\u00a0\uc81c\uacf5\ub41c\ub2e4.<\/p>\n

SABCS 2023\uc5d0\uc11c\u00a0\ubc1c\ud45c\ub418\ub294\u00a0Menarini Group\/ Stemline Therapeutics\uc758\u00a0\uc804\uccb4\u00a0\ubc1c\ud45c\uc5d0\u00a0\ub300\ud55c\u00a0\uc0c1\uc138\u00a0\uc815\ubcf4\ub294\u00a0\uc5ec\uae30<\/a>[https:\/\/www.menarini.com\/en-us\/news\/news-detail\/menarini-group-announces-new-data-on-orserdu174-elacestrant-at-the-2023-san-antonio-breast-cancer-symposium-and-on-elzonris174-tagraxofusp-erzs-at-the-65th-american-society-of-hematology<\/a> ]\ub97c\u00a0\ucc38\uc870\ud55c\ub2e4.<\/p>\n

EMERALD \uc81c3\uc0c1\u00a0\uc2dc\ud5d8(NCT03778931) \uc18c\uac1c<\/p>\n

EMERALD \uc81c3\uc0c1\u00a0\uc784\uc0c1\uc2dc\ud5d8\uc740\u00a0ER+, HER2-\uc9c4\ud589\uc131\/mBC \ud658\uc790\uc5d0\uc11c\u00a0\uc774\ucc28\u00a0\ub610\ub294\u00a0\uc0bc\ucc28\u00a0\ub2e8\ub3c5\uc694\ubc95\uc73c\ub85c\uc11c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\ub97c\u00a0\ud3c9\uac00\ud558\ub294\u00a0\ubb34\uc791\uc704\ubc30\uc815, \uacf5\uac1c, \ud65c\uc131\u00a0\ub300\uc870\u00a0\uc2dc\ud5d8\uc774\ub2e4. \uc774\u00a0\uc2dc\ud5d8\uc740\u00a0CDK4\/6 \uc5b5\uc81c\uc81c\ub97c\u00a0\ud3ec\ud568\ud558\uc5ec\u00a0\ud558\ub098\u00a0\ub610\ub294\u00a0\ub450\u00a0\uac00\uc9c0\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\uc73c\ub85c\u00a0\uc774\uc804\u00a0\uc694\ubc95\uc744\u00a0\ubc1b\uc740\u00a0478\uba85\uc744\u00a0\ub4f1\ub85d\ud558\uc600\ub2e4. \uc774\u00a0\uc2dc\ud5d8\uc758\u00a0\ud658\uc790\ub4e4\uc740\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\ub098\u00a0\uc2dc\ud5d8\uc790\uac00\u00a0\uc120\ud0dd\ud55c\u00a0\uc2b9\uc778\ub41c\u00a0\ud638\ub974\ubaac\u00a0\uc81c\uc81c\u00a0\uc911\u00a0\ud558\ub098\uc5d0\u00a0\ubb34\uc791\uc704\ubc30\uc815\ub418\uc5c8\ub2e4. \uc774\u00a0\uc2dc\ud5d8\uc758\u00a0\uc77c\ucc28\u00a0\ud3c9\uac00\ubcc0\uc218\ub294\u00a0\uc804\uccb4\u00a0\ud658\uc790\u00a0\uc9d1\ub2e8\uacfc\u00a0\uc5d0\uc2a4\ud2b8\ub85c\uac90\u00a0\uc218\uc6a9\uccb4\u00a01 \uc720\uc804\uc790(ESR1) \ubcc0\uc774\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\ubb34\uc9c4\ud589\u00a0\uc0dd\uc874(PFS)\uc774\uc5c8\ub2e4. ESR1-\ubcc0\uc774\uac00\u00a0\uc788\ub294\u00a0\uc885\uc591\u00a0\ud658\uc790\uad70\uc5d0\uc11c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\uc758\u00a0PFS \uc911\uc559\uac12\uc740\u00a03.8\uac1c\uc6d4\uc774\uc5c8\uace0, SOC\uc5d0\uc11c\ub294\u00a01.9\uac1c\uc6d4\ub85c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\ub294\u00a0SOC \ub300\ube44\u00a0\uc9c4\ud589\u00a0\ub610\ub294\u00a0\uc0ac\ub9dd\u00a0\uc704\ud5d8\uc744\u00a045% \ub0ae\ucd94\uc5c8\ub2e4\u00a0\uac10\uc18c\ud558\uc600\ub2e4(PFS HR=0.55, 95% CI: 0.39, 0.77).<\/p>\n

\uc624\ub974\uc138\ub974\ub450(\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8) \uc18c\uac1c\u00a0\ubbf8\uad6d\u00a0\uc801\uc751\uc99d:\u00a0\uc624\ub974\uc138\ub974\ub450(\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8) 345mg \uc815\uc81c\ub294\u00a0\ud558\ub098\u00a0\uc774\uc0c1\uc758\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\u00a0\ud6c4\u00a0\uc9c8\ubcd1\u00a0\uc9c4\ud589\uc744\u00a0\ubcf4\uc778\u00a0\uc5d0\uc2a4\ud2b8\ub85c\uac90\u00a0\uc218\uc6a9\uccb4(ER) \uc591\uc131, \uc778\uac04\u00a0\uc0c1\ud53c\u00a0\uc131\uc7a5\uc778\uc790\u00a0\uc218\uc6a9\uccb4\u00a02(HER2) \uc74c\uc131, ESR1 \ub3cc\uc5f0\ubcc0\uc774\u00a0\uc9c4\ud589\uc131\u00a0\ub610\ub294\u00a0\uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\uc774\u00a0\uc788\ub294\u00a0\ud3d0\uacbd\u00a0\ud6c4\u00a0\uc5ec\uc131\u00a0\ub610\ub294\u00a0\uc131\uc778\u00a0\ub0a8\uc131\uc758\u00a0\uce58\ub8cc\uc5d0\u00a0\uc801\uc751\ub41c\ub2e4.<\/p>\n

\ubbf8\uad6d\uc758\u00a0\uc804\uccb4\u00a0\ucc98\ubc29\u00a0\uc815\ubcf4\ub294\u00a0www.orserdu.com<\/a>\uc5d0\uc11c\u00a0\ucc3e\uc544\ubcfc\u00a0\uc218\u00a0\uc788\ub2e4.<\/p>\n

\uc911\uc694\ud55c\u00a0\uc548\uc804\uc131\u00a0\uc815\ubcf4
\uacbd\uace0\u00a0\ubc0f\u00a0\uc8fc\uc758\uc0ac\ud56d<\/p>\n

\uc774\uc0c1\uc9c0\uc9c8\ud608\uc99d:\u00a0\uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d\uacfc\u00a0\uace0\uc911\uc131\uc9c0\ubc29\ud608\uc99d\uc740\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\uac01\uac01\u00a030% \ubc0f\u00a027% \ubc1c\uc0dd\ub960\ub85c\u00a0\ubc1c\uc0dd\ud588\ub2e4. 3\ub4f1\uae09\u00a0\ubc0f\u00a04\ub4f1\uae09\u00a0\uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d\u00a0\ubc0f\u00a0\uace0\uc911\uc131\uc9c0\ubc29\ud608\uc99d\uc758\u00a0\ubc1c\uc0dd\ub960\uc740\u00a0\uac01\uac01\u00a00.9% \ubc0f\u00a02.2%\uc600\ub2e4. \uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\uc2dc\uc791\u00a0\uc804\uacfc\u00a0\ud22c\uc5ec\u00a0\uc911\u00a0\uc815\uae30\uc801\uc73c\ub85c\u00a0\uc9c0\uc9c8\u00a0\ud504\ub85c\ud30c\uc77c\uc744\u00a0\ubaa8\ub2c8\ud130\ub9c1\ud55c\ub2e4.<\/p>\n

\ubc30\ud0dc\uc544\u00a0\ub3c5\uc131: \ub3d9\ubb3c\u00a0\uad00\ucc30\uacb0\uacfc\uc640\u00a0\uadf8\u00a0\uc791\uc6a9\uae30\uc804\uc5d0\u00a0\uae30\ucd08\ud558\uc5ec\u00a0\uc624\ub974\uc138\ub974\ub450\ub294\u00a0\uc784\uc2e0\ubd80\uc5d0\u00a0\ud22c\uc5ec\u00a0\uc2dc\u00a0\ud0dc\uc544\u00a0\uc190\uc0c1\uc744\u00a0\uc57c\uae30\ud560\u00a0\uc218\u00a0\uc788\ub2e4. \uc784\uc2e0\ubd80\uc640\u00a0\uac00\uc784\u00a0\uc5ec\uc131\uc5d0\uac8c\u00a0\ud0dc\uc544\uc5d0\u00a0\ub300\ud55c\u00a0\uc7a0\uc7ac\uc801\u00a0\uc704\ud5d8\uc744\u00a0\uc548\ub0b4\ud55c\ub2e4. \uac00\uc784\u00a0\uc5ec\uc131\uc740\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\uc911\uacfc\u00a0\ub9c8\uc9c0\ub9c9\u00a0\ud22c\uc5ec\u00a0\ud6c4\u00a01\uc8fc\u00a0\ub3d9\uc548\u00a0\ud6a8\uacfc\uc801\uc778\u00a0\ud53c\uc784\ubc95\uc744\u00a0\uc0ac\uc6a9\ud574\uc57c\u00a0\ud55c\ub2e4. \uac00\uc784\u00a0\uc5ec\uc131\u00a0\ud30c\ud2b8\ub108\uac00\u00a0\uc788\ub294\u00a0\ub0a8\uc131\u00a0\ud658\uc790\ub294\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\uc911\uacfc\u00a0\ub9c8\uc9c0\ub9c9\u00a0\ud22c\uc5ec\u00a0\ud6c4\u00a01\uc8fc\u00a0\ub3d9\uc548\u00a0\ud6a8\uacfc\uc801\uc778\u00a0\ud53c\uc784\ubc95\uc744\u00a0\uc0ac\uc6a9\ud574\uc57c\u00a0\ud55c\ub2e4.<\/p>\n

\uc774\uc0c1\ubc18\uc751<\/p>\n

\uc911\ub300\ud55c\u00a0\uc774\uc0c1\ubc18\uc751\uc740\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\ud658\uc790\uc758\u00a012%\uc5d0\uc11c\u00a0\ubc1c\uc0dd\ud558\uc600\ub2e4. \uc624\ub974\uc138\ub974\ub450\ub97c\u00a0\ud22c\uc5ec\ud55c\u00a0\ud658\uc790\uc758\u00a0>1%\uc5d0\uc11c\u00a0\ubc1c\uc0dd\ud55c\u00a0\uc911\ub300\ud55c\u00a0\uc774\uc0c1\ubc18\uc751\uc740\u00a0\uadfc\uace8\uaca9\ud1b5(1.7%) \ubc0f\u00a0\uba54\uc2a4\uaebc\uc6c0(1.3%)\uc774\uc5c8\ub2e4. \uce58\uba85\uc801\u00a0\uc774\uc0c1\ubc18\uc751\uc740\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\ud658\uc790\uc758\u00a01.7%\uc5d0\uc11c\u00a0\ubc1c\uc0dd\ud558\uc600\uc73c\uba70\u00a0\uc2ec\uc815\uc9c0, \ud328\ud608\uc131\u00a0\uc1fc\ud06c, \uac8c\uc2e4\uc5fc, \ubd88\uba85\uc758\u00a0\uc6d0\uc778(\uac01\u00a01\uba85) \ub4f1\uc774\uc5c8\ub2e4.
\uc2e4\ud5d8\uc2e4\u00a0\ube44\uc815\uc0c1\uc744\u00a0\ud3ec\ud568\ud574\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0\uac00\uc7a5\u00a0\ud754\ud55c\u00a0\uc774\uc0c1\ubc18\uc751(>10%)\uc740\u00a0\uadfc\uace8\uaca9\ud1b5(41%), \uba54\uc2a4\uaebc\uc6c0(35%), \ucf5c\ub808\uc2a4\ud14c\ub864\u00a0\uc99d\uac00(30%), AST \uc99d\uac00(29%), \uc911\uc131\uc9c0\ubc29\u00a0\uc99d\uac00(27%), \ud53c\ub85c(26%), \ud5e4\ubaa8\uae00\ub85c\ube48\u00a0\uac10\uc18c(26%), \uad6c\ud1a0(19%), ALT \uc99d\uac00(17%), \ub098\ud2b8\ub968\u00a0\uac10\uc18c(16%), \ud06c\ub808\uc544\ud2f0\ub2cc\u00a0\uc99d\uac00(16%), \uc2dd\uc695\u00a0\uac10\uc18c(15%), \uc124\uc0ac(13%), \ub450\ud1b5(12%), \ubcc0\ube44(12%), \ubcf5\ud1b5(11%), \uc5bc\uad74\u00a0\ud64d\uc870(11%), \uc18c\ud654\ubd88\ub7c9(10%) \ub4f1\uc774\uc5c8\ub2e4.<\/p>\n

\uc57d\ubb3c\u00a0\uc0c1\ud638\uc791\uc6a9<\/p>\n

CYP3A4 \uc720\ub3c4\uc81c\u00a0\ubc0f\/\ub610\ub294\u00a0\uc5b5\uc81c\uc81c\u00a0\ubcd1\uc6a9:\u00a0 \uac15\ub825\u00a0\ub0b4\uc9c0\u00a0\uc911\ub4f1\ub3c4\u00a0CYP3A4 \uc5b5\uc81c\uc81c\uc640\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0\ubcd1\uc6a9\uc744\u00a0\ud53c\ud55c\ub2e4. \uac15\ub825\u00a0\ub0b4\uc9c0\u00a0\uc911\ub4f1\ub3c4\u00a0CYP3A4 \uc720\ub3c4\uc81c\uc640\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0\ubcd1\uc6a9\uc744\u00a0\ud53c\ud55c\ub2e4.<\/p>\n

\ud2b9\uc218\u00a0\uc9d1\ub2e8\uc5d0\uc11c\uc758\u00a0\uc0ac\uc6a9<\/p>\n

\uc218\uc720: \uc218\uc720\ubd80\ub294\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\ud22c\uc5ec\u00a0\uc911\uacfc\u00a0\ub9c8\uc9c0\ub9c9\u00a0\ud22c\uc5ec\u00a0\ud6c4\u00a01\uc8fc\u00a0\ub3d9\uc548\u00a0\uc218\uc720\ud558\uc9c0\u00a0\uc54a\ub3c4\ub85d\u00a0\uc548\ub0b4\ud55c\ub2e4.<\/p>\n

\uac04\uc7a5\uc560: \uc911\uc99d\u00a0\uac04\uc7a5\uc560(Child-Pugh C) \ud658\uc790\uc5d0\uc11c\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\uc0ac\uc6a9\uc744\u00a0\ud53c\ud55c\ub2e4. \uc911\ub4f1\ub3c4\u00a0\uac04\uc7a5\uc560(Child-Pugh B) \ud658\uc790\uc5d0\uc11c\u00a0\uc624\ub974\uc138\ub974\ub450\u00a0\uc6a9\ub7c9\uc744\u00a0\ub0ae\ucd98\ub2e4.
\uc18c\uc544\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\uc624\ub974\uc138\ub974\ub450\uc758\u00a0\uc548\uc804\uc131\u00a0\ubc0f\u00a0\ud6a8\uacfc\ub294\u00a0\uc218\ub9bd\ub418\uc9c0\u00a0\uc54a\uc558\ub2e4.<\/p>\n

\uc758\uc2ec\ub418\ub294\u00a0\uc774\uc0c1\ubc18\uc751\uc744\u00a0\ubcf4\uace0\ud558\ub824\uba74\u00a0Stemline Therapeutics, Inc.\uc5d0\u00a01-877-332-7961 \ub610\ub294\u00a0FDA\uc5d0\u00a01-800-FDA-1088\u00a0\ub610\ub294\u00a0www.fda.gov\/medwatch<\/a>\ub85c\u00a0\uc5f0\ub77d\ud55c\ub2e4.<\/p>\n

\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\u00a0\uc784\uc0c1\u00a0\uac1c\ubc1c\u00a0\ud504\ub85c\uadf8\ub7a8\u00a0\uc18c\uac1c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\ub294\u00a0\uc77c\ubd80\u00a0\uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c\u00a0\uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\u00a0\uc9c8\ud658\uc5d0\u00a0\ub300\ud574\u00a0\ub2e8\ub3c5\uc694\ubc95\uc73c\ub85c\ub098\u00a0\ub2e4\ub978\u00a0\uc694\ubc95\uacfc\uc758\u00a0\ubcd1\uc6a9\uc694\ubc95\uc73c\ub85c\u00a0\uc5f0\uad6c\u00a0\uc911\uc774\ub2e4. ELEVATE(NCT05563220<\/a>[https:\/\/clinicaltrials.gov\/study\/NCT05563220<\/a> ])\ub294\u00a0\uc54c\ud3a0\ub9ac\uc2ed, \uc5d0\ubca0\ub864\ub9ac\ubb34\uc2a4, \ud314\ubcf4\uc2dc\ud074\ub9bd, \uc544\ubca0\ub9c8\uc2dc\ud074\ub9bd, \ub9ac\ubcf4\uc2dc\ud074\ub9bd\uacfc\u00a0\ubcd1\uc6a9\ud55c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\uc758\u00a0\uc548\uc804\uc131\u00a0\ubc0f\u00a0\uc720\ud6a8\uc131\uc744\u00a0\ud3c9\uac00\ud558\ub294\u00a0\uc81c1b\/2\uc0c1\u00a0\uc784\uc0c1\uc2dc\ud5d8\uc774\ub2e4. ELECTRA(NCT05386108<\/a>[https:\/\/clinicaltrials.gov\/study\/NCT05386108<\/a> ])\ub294\u00a0ER+, HER2- \uc720\ubc29\uc554\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\uc544\ubca0\ub9c8\uc2dc\ud074\ub9bd\uacfc\u00a0\ubcd1\uc6a9\ud55c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\ub97c\u00a0\ud3c9\uac00\ud558\ub294\u00a0\uacf5\uac1c, \uc81c1b\/2\uc0c1, \ub2e4\uae30\uad00\u00a0\uc2dc\ud5d8\uc774\ub2e4. \uc774\u00a0\uc81c2\uc0c1\u00a0\ubd80\ubd84\uc740\u00a0\uc774\u00a0\uc911\u00a0\ub1cc\uc804\uc774\uac00\u00a0\uc788\ub294\u00a0\ud658\uc790\u00a0\uc9d1\ub2e8\uc5d0\uc11c\u00a0\uc774\u00a0\ud22c\uc5ec\u00a0\uc694\ubc95\uc744\u00a0\ud3c9\uac00\ud55c\ub2e4. ELCIN(NCT05596409<\/a>[https:\/\/clinicaltrials.gov\/study\/NCT05596409<\/a> ])\uc740\u00a0\ud558\ub098\u00a0\ub610\ub294\u00a0\ub450\u00a0\uac00\uc9c0\u00a0\uc774\uc804\u00a0\ud638\ub974\ubaac\u00a0\uc694\ubc95\uc744\u00a0\ubc1b\uc558\uc73c\uba70\u00a0\uc804\uc774\u00a0\uc0c1\ud0dc\uc5d0\uc11c\u00a0\uc0ac\uc774\ud074\ub9b0\u00a0\uc758\uc874\uc131\u00a0\ud0a4\ub098\uc544\uc81c\u00a0\ud45c\uc801\u00a0\ud6a8\uc18c\u00a0CDK4 \ubc0f\u00a0CDK6 \uc5b5\uc81c\uc81c(CDK4\/6i)\ub97c\u00a0\ud22c\uc5ec\u00a0\ubc1b\uc740\u00a0\uc801\uc774\u00a0\uc5c6\ub294\u00a0\uc5d0\uc2a4\ud2b8\ub85c\uac90\u00a0\uc218\uc6a9\uccb4\u00a0\uc591\uc131(ER+)\/\uc778\uac04\u00a0\uc0c1\ud53c\uc131\uc7a5\u00a0\uc778\uc790\u00a0\uc218\uc6a9\uccb42 \uc74c\uc131(HER2-) \uc9c4\ud589\uc131\/\uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\u00a0\ud658\uc790\uc5d0\uc11c\u00a0\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8\uc758\u00a0\uc720\ud6a8\uc131\uc744\u00a0\ud3c9\uac00\ud558\ub294\u00a0\uc81c2\uc0c1\u00a0\uc784\uc0c1\uc2dc\ud5d8\uc774\ub2e4.<\/p>\n

Menarini Group \uc18c\uac1c<\/p>\n

Menarini Group\uc740\u00a044\uc5b5\u00a0\ub2ec\ub7ec\u00a0\uc774\uc0c1\uc758\u00a0\ub9e4\ucd9c\uacfc\u00a017000\uba85\uc774\u00a0\ub118\ub294\u00a0\uc9c1\uc6d0\uc744\u00a0\ub454\u00a0\uc120\ub3c4\uc801\uc778\u00a0\uad6d\uc81c\u00a0\uc81c\uc57d\u00a0\ubc0f\u00a0\uc9c4\ub2e8\u00a0\ud68c\uc0ac\uc774\ub2e4. Menarini\ub294\u00a0\uc2ec\uc7a5\ud559, \uc885\uc591\ud559, \ud638\ud761\uae30\ud559, \uc18c\ud654\uae30\ud559, \uac10\uc5fc\u00a0\uc9c8\ud658, \ub2f9\ub1e8\ubcd1, \uc5fc\uc99d\u00a0\ubc0f\u00a0\uc9c4\ud1b5\u00a0\uc758\uc57d\ud488\uc73c\ub85c\u00a0\ubd80\ud569\ub418\uc9c0\u00a0\uc54a\ub294\u00a0\ud544\uc694\uac00\u00a0\ub192\uc740\u00a0\uce58\ub8cc\u00a0\uc601\uc5ed\uc5d0\u00a0\uc911\uc810\uc744\u00a0\ub454\ub2e4. 18\uac1c\u00a0\uc81c\uc870\uc18c\uc640\u00a08\uac1c\u00a0\uc5f0\uad6c\uac1c\ubc1c\u00a0\uc13c\ud130\uac00\u00a0\uc788\ub294\u00a0Menarini Group\uc758\u00a0\uc758\uc57d\ud488\uc740\u00a0\uc804\u00a0\uc138\uacc4\u00a0140\uac1c\uad6d\uc5d0\u00a0\uc81c\uacf5\ub41c\ub2e4. \ucd94\uac00\u00a0\uc815\ubcf4\ub294\u00a0www.menarini.com<\/a>\uc744\u00a0\ubc29\ubb38\ud55c\ub2e4.<\/p>\n

Stemline Therapeutics Inc. \uc18c\uac1c
Stemline Therapeutics Inc.(\uc774\ud558\u00a0‘Stemline’)\uc740\u00a0Menarini Group\uc758\u00a0\uc644\uc804\u00a0\uc18c\uc720\u00a0\uc790\ud68c\uc0ac\ub85c\u00a0\uc0c8\ub85c\uc6b4\u00a0\uc554\uce58\ub8cc\uc81c\uc758\u00a0\uac1c\ubc1c\u00a0\ubc0f\u00a0\uc0c1\uc6a9\ud654\uc5d0\u00a0\uc911\uc810\uc744\u00a0\ub454\u00a0\uc0c1\uc6a9\u00a0\ub2e8\uacc4\u00a0\uc0dd\ubb3c\uc758\uc57d\ud488\u00a0\ud68c\uc0ac\uc774\ub2e4. Stemline\uc740\u00a0\ubbf8\uad6d\uacfc\u00a0\uc720\ub7fd\u00a0\uc5f0\ud569\uc5d0\uc11c\u00a0\ud558\ub098\u00a0\uc774\uc0c1\uc758\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\u00a0\ud6c4\u00a0\uc9c8\ubcd1\u00a0\uc9c4\ud589\uc744\u00a0\ubcf4\uc778\u00a0\uc5d0\uc2a4\ud2b8\ub85c\uac90\u00a0\uc218\uc6a9\uccb4(ER) \uc591\uc131, \uc778\uac04\u00a0\uc0c1\ud53c\uc131\uc7a5\uc778\uc790\u00a0\uc218\uc6a9\uccb4\u00a01(HER2) \uc74c\uc131, ESR1 \ub3cc\uc5f0\ubcc0\uc774\u00a0\uc9c4\ud589\uc131\u00a0\ub610\ub294\u00a0\uc804\uc774\uc131\u00a0\uc720\ubc29\uc554\uc774\u00a0\uc788\ub294\u00a0\ud3d0\uacbd\u00a0\ud6c4\u00a0\uc5ec\uc131\u00a0\ub610\ub294\u00a0\uc131\uc778\u00a0\ub0a8\uc131\uc758\u00a0\uce58\ub8cc\uc5d0\u00a0\uc801\uc751\ub418\ub294\u00a0\uacbd\uad6c\u00a0\ub0b4\ubd84\ube44\u00a0\uc694\ubc95\uc778\u00a0\uc624\ub974\uc138\ub974\ub450\u00ae(\uc5d8\ub77c\uc138\uc2a4\ud2b8\ub780\ud2b8)\ub97c\u00a0\uc2dc\ud310\ud558\uace0\u00a0\uc788\ub2e4. Stemline\uc740\u00a0\uacf5\uaca9\uc801\u00a0\ud608\uc561\uc554\uc778\u00a0\ubaa8\uad6c\u00a0\ud615\uc9c8\uc138\ud3ec\uc591\u00a0\uc218\uc9c0\uc138\ud3ec\u00a0\uc885\uc591(BPDCN) \ud658\uc790\uc5d0\uc11c\u00a0CD123\uc744\u00a0\ud45c\uc801\ud558\ub294\u00a0\uc0c8\ub85c\uc6b4\u00a0\ud45c\uc801\u00a0\uce58\ub8cc\uc81c\uc778\u00a0\uc5d8\uc874\ub9ac\uc2a4(ELZONRIS\u00ae, \uc131\ubd84\uba85: \ud0c0\uadf8\ub77d\uc18c\ud478\ub974\ud504[tagraxofusp-erzs])\ub3c4\u00a0\ubbf8\uad6d\uacfc\u00a0\uc720\ub7fd\uc5d0\uc11c\u00a0\ud310\ub9e4\ud558\uace0\u00a0\uc788\ub2e4. \uc774\ub294\u00a0\ud604\uc7ac\uae4c\uc9c0\u00a0\ubbf8\uad6d\uacfc\u00a0\uc720\ub7fd\uc5f0\ud569\uc5d0\uc11cBPDCN\uc5d0\u00a0\ub300\ud574\u00a0\uc2b9\uc778\ub41c\u00a0\uc720\uc77c\ud55c\u00a0\uce58\ub8cc\uc81c\uc774\ub2e4. Stemline\uc740\u00a0\ub2e4\ubc1c\uc131\u00a0\uace8\uc218\uc885\uc5d0\u00a0\ub300\ud55c\u00a0XPO1 \uc5b5\uc81c\uc81c\uc778\u00a0\ub125\uc2a4\ud3ec\ube44\uc624(NEXPOVIO\u00ae, \uc131\ubd84\uba85: \uc140\ub9ac\ub125\uc18c[Selinexor])\ub3c4\u00a0\uc720\ub7fd\uc5d0\uc11c\u00a0\ud310\ub9e4\ud558\uace0\u00a0\uc788\ub2e4. Stemline\uc740\u00a0\uc5ec\ub7ec\u00a0\uace0\ud615\uc554\u00a0\ubc0f\u00a0\ud608\uc561\uc554\uc5d0\u00a0\ub300\ud574\u00a0\uc5ec\ub7ec\u00a0\ub2e8\uacc4\ub85c\u00a0\uac1c\ubc1c\ub418\uace0\u00a0\uc788\ub294\u00a0\uad11\ubc94\uc704\ud55c\u00a0\uc18c\ubd84\uc790\u00a0\ubc0f\u00a0\uc0dd\ubb3c\ud559\uc801\u00a0\uc758\uc57d\ud488\u00a0\uc784\uc0c1\u00a0\ud30c\uc774\ud504\ub77c\uc778\ub3c4\u00a0\ubcf4\uc720\ud558\uace0\u00a0\uc788\ub2e4.<\/p>\n

[1]\u00a0Bardia et al. EMERALD phase 3 trial of elacestrant versus standard of care endocrine therapy in patients with ER+\/HER2- metastatic breast cancer: Updated results by duration of prior CDK4\/6i in metastatic setting. SABCS 2022. GS3-01<\/p>\n

\ub85c\uace0\u00a0–\u00a0https:\/\/mma.prnasia.com\/media2\/2296569\/Menarini_Industrie_Farmaceutiche_Riunite_Logo.jpg?p=medium600<\/a><\/p>\n

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